diff --git a/CMakeLists.txt b/CMakeLists.txt
index 47f8ebdca8581..c62be499e4952 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -597,7 +597,14 @@ if(DEFINED ENV{LDFLAGS})
   deduplicate_flags(CMAKE_EXE_LINKER_FLAGS)
 endif()
 
-set(CMAKE_SKIP_RPATH TRUE)
+# TODO: The `CMAKE_SKIP_BUILD_RPATH` variable setting can be deleted
+#       in the future after reordering Guix script commands to
+#       perform binary checks after the installation step.
+# Relevant discussions:
+# - https://github.com/hebasto/bitcoin/pull/236#issuecomment-2183120953
+# - https://github.com/bitcoin/bitcoin/pull/30312#issuecomment-2191235833
+set(CMAKE_SKIP_BUILD_RPATH TRUE)
+set(CMAKE_SKIP_INSTALL_RPATH TRUE)
 add_subdirectory(src)
 add_subdirectory(test)
 add_subdirectory(doc)
diff --git a/src/CMakeLists.txt b/src/CMakeLists.txt
index bb466e6868cca..6116b817bc403 100644
--- a/src/CMakeLists.txt
+++ b/src/CMakeLists.txt
@@ -355,6 +355,15 @@ if(BUILD_UTIL_CHAINSTATE)
   add_executable(bitcoin-chainstate
     bitcoin-chainstate.cpp
   )
+  # TODO: The `SKIP_BUILD_RPATH` property setting can be deleted
+  #       in the future after reordering Guix script commands to
+  #       perform binary checks after the installation step.
+  # Relevant discussions:
+  # - https://github.com/hebasto/bitcoin/pull/236#issuecomment-2183120953
+  # - https://github.com/bitcoin/bitcoin/pull/30312#issuecomment-2191235833
+  set_target_properties(bitcoin-chainstate PROPERTIES
+    SKIP_BUILD_RPATH OFF
+  )
   target_link_libraries(bitcoin-chainstate
     PRIVATE
       core_interface