diff --git a/CMakeLists.txt b/CMakeLists.txt
index 3f219d364fae2..83616cbbdbb1d 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -145,9 +145,7 @@ cmake_dependent_option(WITH_QRENCODE "Enable QR code support." ON "BUILD_GUI" OF
 if(WITH_QRENCODE)
   find_package(PkgConfig REQUIRED)
   pkg_check_modules(libqrencode REQUIRED IMPORTED_TARGET libqrencode)
-  target_compile_definitions(PkgConfig::libqrencode INTERFACE
-    USE_QRCODE
-  )
+  set(USE_QRCODE TRUE)
 endif()
 
 cmake_dependent_option(WITH_DBUS "Enable DBus support." ON "CMAKE_SYSTEM_NAME STREQUAL \"Linux\" AND BUILD_GUI" OFF)
@@ -166,6 +164,7 @@ if(BUILD_GUI)
   endif()
   if(WITH_DBUS)
     list(APPEND qt_components DBus)
+    set(USE_DBUS TRUE)
   endif()
   if(BUILD_GUI_TESTS)
     list(APPEND qt_components Test)
diff --git a/cmake/bitcoin-config.h.in b/cmake/bitcoin-config.h.in
index 9951cd0874ea3..01d3f379235fa 100644
--- a/cmake/bitcoin-config.h.in
+++ b/cmake/bitcoin-config.h.in
@@ -29,6 +29,28 @@
 /* Copyright year */
 #define COPYRIGHT_YEAR @COPYRIGHT_YEAR@
 
+/* Define this symbol to build code that uses ARMv8 SHA-NI intrinsics */
+#cmakedefine ENABLE_ARM_SHANI 1
+
+/* Define this symbol to build code that uses AVX2 intrinsics */
+#cmakedefine ENABLE_AVX2 1
+
+/* Define if external signer support is enabled */
+#cmakedefine ENABLE_EXTERNAL_SIGNER 1
+
+/* Define this symbol to build code that uses SSE4.1 intrinsics */
+#cmakedefine ENABLE_SSE41 1
+
+/* Define to 1 to enable tracepoints for Userspace, Statically Defined Tracing
+   */
+#cmakedefine ENABLE_TRACING 1
+
+/* Define to 1 to enable wallet functions. */
+#cmakedefine ENABLE_WALLET 1
+
+/* Define this symbol to build code that uses x86 SHA-NI intrinsics */
+#cmakedefine ENABLE_X86_SHANI 1
+
 /* Define to 1 if you have the declaration of `fork', and to 0 if you don't.
    */
 #cmakedefine01 HAVE_DECL_FORK
@@ -55,6 +77,9 @@
 /* Define if the dllexport attribute is supported. */
 #cmakedefine HAVE_DLLEXPORT_ATTRIBUTE 1
 
+/* Define this symbol if evhttp_connection_get_peer expects const char** */
+#cmakedefine HAVE_EVHTTP_CONNECTION_GET_PEER_CONST_CHAR 1
+
 /* Define to 1 if fdatasync is available. */
 #cmakedefine HAVE_FDATASYNC 1
 
@@ -119,16 +144,16 @@
 /* Define to 1 if strerror_r returns char *. */
 #cmakedefine STRERROR_R_CHAR_P 1
 
-/* Define to 1 to enable wallet functions. */
-#cmakedefine ENABLE_WALLET 1
+/* Define if BDB support should be compiled in */
+#cmakedefine USE_BDB 1
 
-/* Define if SQLite support should be compiled in. */
-#cmakedefine USE_SQLITE
+/* Define if dbus support should be compiled in */
+#cmakedefine USE_DBUS 1
 
-/* Define if Berkeley DB (BDB) support should be compiled in. */
-#cmakedefine USE_BDB
+/* Define if QR support should be compiled in */
+#cmakedefine USE_QRCODE 1
 
-/* Define if external signer support is enabled. */
-#cmakedefine ENABLE_EXTERNAL_SIGNER
+/* Define if sqlite support should be compiled in */
+#cmakedefine USE_SQLITE 1
 
 #endif //BITCOIN_CONFIG_H
diff --git a/cmake/introspection.cmake b/cmake/introspection.cmake
index 0d5462e84c3a2..d0d16aec2f198 100644
--- a/cmake/introspection.cmake
+++ b/cmake/introspection.cmake
@@ -177,3 +177,70 @@ check_cxx_source_compiles("
   int main(){}
   " HAVE_DLLEXPORT_ATTRIBUTE
 )
+
+if(NOT MSVC)
+  include(CheckSourceCompilesAndLinks)
+
+  # Check for SSE4.1 intrinsics.
+  set(SSE41_CXXFLAGS -msse4.1)
+  check_cxx_source_compiles_with_flags("${SSE41_CXXFLAGS}" "
+    #include <immintrin.h>
+
+    int main()
+    {
+      __m128i a = _mm_set1_epi32(0);
+      __m128i b = _mm_set1_epi32(1);
+      __m128i r = _mm_blend_epi16(a, b, 0xFF);
+      return _mm_extract_epi32(r, 3);
+    }
+    " HAVE_SSE41
+  )
+  set(ENABLE_SSE41 ${HAVE_SSE41})
+
+  # Check for AVX2 intrinsics.
+  set(AVX2_CXXFLAGS -mavx -mavx2)
+  check_cxx_source_compiles_with_flags("${AVX2_CXXFLAGS}" "
+    #include <immintrin.h>
+
+    int main()
+    {
+      __m256i l = _mm256_set1_epi32(0);
+      return _mm256_extract_epi32(l, 7);
+    }
+    " HAVE_AVX2
+  )
+  set(ENABLE_AVX2 ${HAVE_AVX2})
+
+  # Check for x86 SHA-NI intrinsics.
+  set(X86_SHANI_CXXFLAGS -msse4 -msha)
+  check_cxx_source_compiles_with_flags("${X86_SHANI_CXXFLAGS}" "
+    #include <immintrin.h>
+
+    int main()
+    {
+      __m128i i = _mm_set1_epi32(0);
+      __m128i j = _mm_set1_epi32(1);
+      __m128i k = _mm_set1_epi32(2);
+      return _mm_extract_epi32(_mm_sha256rnds2_epu32(i, j, k), 0);
+    }
+    " HAVE_X86_SHANI
+  )
+  set(ENABLE_X86_SHANI ${HAVE_X86_SHANI})
+
+  # Check for ARMv8 SHA-NI intrinsics.
+  set(ARM_SHANI_CXXFLAGS -march=armv8-a+crypto)
+  check_cxx_source_compiles_with_flags("${ARM_SHANI_CXXFLAGS}" "
+    #include <arm_neon.h>
+
+    int main()
+    {
+      uint32x4_t a, b, c;
+      vsha256h2q_u32(a, b, c);
+      vsha256hq_u32(a, b, c);
+      vsha256su0q_u32(a, b);
+      vsha256su1q_u32(a, b, c);
+    }
+    " HAVE_ARM_SHANI
+  )
+  set(ENABLE_ARM_SHANI ${HAVE_ARM_SHANI})
+endif()
diff --git a/cmake/module/FindLibevent.cmake b/cmake/module/FindLibevent.cmake
index 9207d967ec737..901a4f3bd41ec 100644
--- a/cmake/module/FindLibevent.cmake
+++ b/cmake/module/FindLibevent.cmake
@@ -35,9 +35,7 @@ function(check_evhttp_connection_get_peer target)
     " HAVE_EVHTTP_CONNECTION_GET_PEER_CONST_CHAR
   )
   cmake_pop_check_state()
-  target_compile_definitions(${target} INTERFACE
-    $<$<BOOL:${HAVE_EVHTTP_CONNECTION_GET_PEER_CONST_CHAR}>:HAVE_EVHTTP_CONNECTION_GET_PEER_CONST_CHAR>
-  )
+  set(HAVE_EVHTTP_CONNECTION_GET_PEER_CONST_CHAR ${HAVE_EVHTTP_CONNECTION_GET_PEER_CONST_CHAR} PARENT_SCOPE)
 endfunction()
 
 
diff --git a/cmake/module/FindUSDT.cmake b/cmake/module/FindUSDT.cmake
index 496b5fb18f4a2..0ba9a58fc10ac 100644
--- a/cmake/module/FindUSDT.cmake
+++ b/cmake/module/FindUSDT.cmake
@@ -59,6 +59,6 @@ if(USDT_FOUND AND NOT TARGET USDT::headers)
   add_library(USDT::headers INTERFACE IMPORTED)
   set_target_properties(USDT::headers PROPERTIES
     INTERFACE_INCLUDE_DIRECTORIES "${USDT_INCLUDE_DIR}"
-    INTERFACE_COMPILE_DEFINITIONS ENABLE_TRACING
   )
+  set(ENABLE_TRACING TRUE)
 endif()
diff --git a/src/crypto/CMakeLists.txt b/src/crypto/CMakeLists.txt
index 6c971c5b3ec0e..3b3b322c47f06 100644
--- a/src/crypto/CMakeLists.txt
+++ b/src/crypto/CMakeLists.txt
@@ -2,69 +2,6 @@
 # Distributed under the MIT software license, see the accompanying
 # file COPYING or http://www.opensource.org/licenses/mit-license.php.
 
-if(NOT MSVC)
-  include(CheckSourceCompilesAndLinks)
-
-  # Check for SSE4.1 intrinsics.
-  set(SSE41_CXXFLAGS -msse4.1)
-  check_cxx_source_compiles_with_flags("${SSE41_CXXFLAGS}" "
-    #include <immintrin.h>
-
-    int main()
-    {
-      __m128i a = _mm_set1_epi32(0);
-      __m128i b = _mm_set1_epi32(1);
-      __m128i r = _mm_blend_epi16(a, b, 0xFF);
-      return _mm_extract_epi32(r, 3);
-    }
-    " HAVE_SSE41
-  )
-
-  # Check for AVX2 intrinsics.
-  set(AVX2_CXXFLAGS -mavx -mavx2)
-  check_cxx_source_compiles_with_flags("${AVX2_CXXFLAGS}" "
-    #include <immintrin.h>
-
-    int main()
-    {
-      __m256i l = _mm256_set1_epi32(0);
-      return _mm256_extract_epi32(l, 7);
-    }
-    " HAVE_AVX2
-  )
-
-  # Check for x86 SHA-NI intrinsics.
-  set(X86_SHANI_CXXFLAGS -msse4 -msha)
-  check_cxx_source_compiles_with_flags("${X86_SHANI_CXXFLAGS}" "
-    #include <immintrin.h>
-
-    int main()
-    {
-      __m128i i = _mm_set1_epi32(0);
-      __m128i j = _mm_set1_epi32(1);
-      __m128i k = _mm_set1_epi32(2);
-      return _mm_extract_epi32(_mm_sha256rnds2_epu32(i, j, k), 0);
-    }
-    " HAVE_X86_SHANI
-  )
-
-  # Check for ARMv8 SHA-NI intrinsics.
-  set(ARM_SHANI_CXXFLAGS -march=armv8-a+crypto)
-  check_cxx_source_compiles_with_flags("${ARM_SHANI_CXXFLAGS}" "
-    #include <arm_neon.h>
-
-    int main()
-    {
-      uint32x4_t a, b, c;
-      vsha256h2q_u32(a, b, c);
-      vsha256hq_u32(a, b, c);
-      vsha256su0q_u32(a, b);
-      vsha256su1q_u32(a, b, c);
-    }
-    " HAVE_ARM_SHANI
-  )
-endif()
-
 add_library(bitcoin_crypto STATIC EXCLUDE_FROM_ALL
   aes.cpp
   chacha20.cpp
diff --git a/src/crypto/sha256.cpp b/src/crypto/sha256.cpp
index 8e3586540829c..89d7204808459 100644
--- a/src/crypto/sha256.cpp
+++ b/src/crypto/sha256.cpp
@@ -2,6 +2,8 @@
 // Distributed under the MIT software license, see the accompanying
 // file COPYING or http://www.opensource.org/licenses/mit-license.php.
 
+#include <config/bitcoin-config.h> // IWYU pragma: keep
+
 #include <crypto/sha256.h>
 #include <crypto/common.h>
 
diff --git a/src/httpserver.cpp b/src/httpserver.cpp
index 9db0f52fb567f..b6c6db8b35553 100644
--- a/src/httpserver.cpp
+++ b/src/httpserver.cpp
@@ -2,6 +2,8 @@
 // Distributed under the MIT software license, see the accompanying
 // file COPYING or http://www.opensource.org/licenses/mit-license.php.
 
+#include <config/bitcoin-config.h> // IWYU pragma: keep
+
 #include <httpserver.h>
 
 #include <chainparamsbase.h>
diff --git a/src/qt/CMakeLists.txt b/src/qt/CMakeLists.txt
index beda704a748d7..90bab3675c1b2 100644
--- a/src/qt/CMakeLists.txt
+++ b/src/qt/CMakeLists.txt
@@ -212,7 +212,6 @@ if(ENABLE_WALLET)
 endif()
 
 if(WITH_DBUS)
-  target_compile_definitions(bitcoinqt PRIVATE USE_DBUS)
   target_link_libraries(bitcoinqt PRIVATE Qt5::DBus)
 endif()
 
diff --git a/src/qt/notificator.cpp b/src/qt/notificator.cpp
index 6eeb19cd20acd..85bdeee49a0df 100644
--- a/src/qt/notificator.cpp
+++ b/src/qt/notificator.cpp
@@ -2,6 +2,8 @@
 // Distributed under the MIT software license, see the accompanying
 // file COPYING or http://www.opensource.org/licenses/mit-license.php.
 
+#include <config/bitcoin-config.h> // IWYU pragma: keep
+
 #include <qt/notificator.h>
 
 #include <QApplication>
diff --git a/src/qt/notificator.h b/src/qt/notificator.h
index f72a859f89af4..8808716aa4dca 100644
--- a/src/qt/notificator.h
+++ b/src/qt/notificator.h
@@ -5,6 +5,8 @@
 #ifndef BITCOIN_QT_NOTIFICATOR_H
 #define BITCOIN_QT_NOTIFICATOR_H
 
+#include <config/bitcoin-config.h> // IWYU pragma: keep
+
 #include <QIcon>
 #include <QObject>
 
diff --git a/src/qt/qrimagewidget.cpp b/src/qt/qrimagewidget.cpp
index 9aa2db9cd97c3..f6e712a047a3e 100644
--- a/src/qt/qrimagewidget.cpp
+++ b/src/qt/qrimagewidget.cpp
@@ -15,6 +15,8 @@
 #include <QMouseEvent>
 #include <QPainter>
 
+#include <config/bitcoin-config.h> // IWYU pragma: keep
+
 #ifdef USE_QRCODE
 #include <qrencode.h>
 #endif
diff --git a/src/qt/receiverequestdialog.cpp b/src/qt/receiverequestdialog.cpp
index a3528d7e0069e..b4322ddc0f436 100644
--- a/src/qt/receiverequestdialog.cpp
+++ b/src/qt/receiverequestdialog.cpp
@@ -14,6 +14,8 @@
 #include <QDialog>
 #include <QString>
 
+#include <config/bitcoin-config.h> // IWYU pragma: keep
+
 ReceiveRequestDialog::ReceiveRequestDialog(QWidget* parent)
     : QDialog(parent, GUIUtil::dialog_flags),
       ui(new Ui::ReceiveRequestDialog)
diff --git a/src/util/trace.h b/src/util/trace.h
index 7a63f39c83f94..d9ed65e3aab56 100644
--- a/src/util/trace.h
+++ b/src/util/trace.h
@@ -5,6 +5,8 @@
 #ifndef BITCOIN_UTIL_TRACE_H
 #define BITCOIN_UTIL_TRACE_H
 
+#include <config/bitcoin-config.h> // IWYU pragma: keep
+
 #ifdef ENABLE_TRACING
 
 #include <sys/sdt.h>