diff --git a/CMakeLists.txt b/CMakeLists.txt
index 75f7e70e59e44..798276785c356 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -496,6 +496,9 @@ if(CMAKE_CROSSCOMPILING)
   if(DEFINED ENV{CXXFLAGS})
     deduplicate_flags(CMAKE_CXX_FLAGS)
   endif()
+  if(DEFINED ENV{LDFLAGS})
+    deduplicate_flags(CMAKE_EXE_LINKER_FLAGS)
+  endif()
 endif()
 
 add_subdirectory(src)
@@ -507,6 +510,7 @@ include(Maintenance)
 setup_split_debug_script()
 add_maintenance_targets()
 add_windows_deploy_target()
+add_macos_deploy_target()
 
 
 include(GetTargetInterface)
diff --git a/cmake/module/Maintenance.cmake b/cmake/module/Maintenance.cmake
index b552e408658dd..2834bdbb2f95f 100644
--- a/cmake/module/Maintenance.cmake
+++ b/cmake/module/Maintenance.cmake
@@ -88,3 +88,64 @@ function(add_windows_deploy_target)
     add_custom_target(deploy DEPENDS ${CMAKE_BINARY_DIR}/bitcoin-win64-setup.exe)
   endif()
 endfunction()
+
+function(add_macos_deploy_target)
+  if(CMAKE_SYSTEM_NAME STREQUAL "Darwin" AND TARGET bitcoin-qt)
+    set(macos_app "Bitcoin-Qt.app")
+    # Populate Contents subdirectory.
+    configure_file(${PROJECT_SOURCE_DIR}/share/qt/Info.plist.in ${macos_app}/Contents/Info.plist)
+    file(CONFIGURE OUTPUT ${macos_app}/Contents/PkgInfo CONTENT "APPL????")
+    # Populate Contents/Resources subdirectory.
+    file(CONFIGURE OUTPUT ${macos_app}/Contents/Resources/empty.lproj CONTENT "")
+    configure_file(${PROJECT_SOURCE_DIR}/src/qt/res/icons/bitcoin.icns ${macos_app}/Contents/Resources/bitcoin.icns COPYONLY)
+    file(CONFIGURE OUTPUT ${macos_app}/Contents/Resources/Base.lproj/InfoPlist.strings
+      CONTENT "{ CFBundleDisplayName = \"@PACKAGE_NAME@\"; CFBundleName = \"@PACKAGE_NAME@\"; }"
+    )
+
+    add_custom_command(
+      OUTPUT ${CMAKE_BINARY_DIR}/${macos_app}/Contents/MacOS/Bitcoin-Qt
+      COMMAND ${CMAKE_COMMAND} --install ${CMAKE_BINARY_DIR} --config $<CONFIG> --component GUI --prefix ${macos_app}/Contents/MacOS --strip
+      COMMAND ${CMAKE_COMMAND} -E rename ${macos_app}/Contents/MacOS/bin/$<TARGET_FILE_NAME:bitcoin-qt> ${macos_app}/Contents/MacOS/Bitcoin-Qt
+      COMMAND ${CMAKE_COMMAND} -E rm -rf ${macos_app}/Contents/MacOS/bin
+      VERBATIM
+    )
+
+    string(REPLACE " " "-" osx_volname ${PACKAGE_NAME})
+    if(CMAKE_CROSSCOMPILING)
+      add_custom_command(
+        OUTPUT ${CMAKE_BINARY_DIR}/dist/${macos_app}/Contents/MacOS/Bitcoin-Qt
+        COMMAND INSTALL_NAME_TOOL=${CMAKE_INSTALL_NAME_TOOL} OTOOL=${OTOOL} STRIP=${CMAKE_STRIP} ${PYTHON_COMMAND} ${CMAKE_SOURCE_DIR}/contrib/macdeploy/macdeployqtplus ${macos_app} ${osx_volname} -translations-dir=${QT_TRANSLATIONS_DIR}
+        DEPENDS ${CMAKE_BINARY_DIR}/${macos_app}/Contents/MacOS/Bitcoin-Qt
+        VERBATIM
+      )
+      add_custom_target(deploydir
+        DEPENDS ${CMAKE_BINARY_DIR}/dist/${macos_app}/Contents/MacOS/Bitcoin-Qt
+      )
+
+      find_program(ZIP_COMMAND zip REQUIRED)
+      add_custom_command(
+        OUTPUT ${CMAKE_BINARY_DIR}/dist/${osx_volname}.zip
+        WORKING_DIRECTORY dist
+        COMMAND ${PROJECT_SOURCE_DIR}/cmake/script/macos_zip.sh ${ZIP_COMMAND} ${osx_volname}.zip
+        VERBATIM
+      )
+      add_custom_target(deploy
+        DEPENDS ${CMAKE_BINARY_DIR}/dist/${osx_volname}.zip
+      )
+      add_dependencies(deploy deploydir)
+    else()
+      add_custom_command(
+        OUTPUT ${CMAKE_BINARY_DIR}/${osx_volname}.zip
+        COMMAND ${PYTHON_COMMAND} ${CMAKE_SOURCE_DIR}/contrib/macdeploy/macdeployqtplus ${macos_app} ${osx_volname} -translations-dir=${QT_TRANSLATIONS_DIR} -zip
+        DEPENDS ${macos_app}/Contents/MacOS/Bitcoin-Qt
+        VERBATIM
+      )
+      add_custom_target(deploydir
+        DEPENDS ${CMAKE_BINARY_DIR}/${osx_volname}.zip
+      )
+      add_custom_target(deploy
+        DEPENDS ${CMAKE_BINARY_DIR}/${osx_volname}.zip
+      )
+    endif()
+  endif()
+endfunction()
diff --git a/cmake/script/macos_zip.sh b/cmake/script/macos_zip.sh
new file mode 100755
index 0000000000000..5a42d1bbf4077
--- /dev/null
+++ b/cmake/script/macos_zip.sh
@@ -0,0 +1,10 @@
+#!/bin/sh
+# Copyright (c) 2024-present The Bitcoin Core developers
+# Distributed under the MIT software license, see the accompanying
+# file COPYING or https://opensource.org/license/mit/.
+
+if [ -n "$SOURCE_DATE_EPOCH" ]; then
+  find . -exec touch -d "@$SOURCE_DATE_EPOCH" {} +
+fi
+
+find . | sort | "$1" -X@ "$2"
diff --git a/contrib/guix/guix-build b/contrib/guix/guix-build
index 731355598cb13..870938cb52acf 100755
--- a/contrib/guix/guix-build
+++ b/contrib/guix/guix-build
@@ -75,12 +75,9 @@ mkdir -p "$VERSION_BASE"
 
 # Default to building for all supported HOSTs (overridable by environment)
 # powerpc64le-linux-gnu currently disabled due non-determinism issues across build arches.
-# TODO: Re-enable macOS hosts.
-# export HOSTS="${HOSTS:-x86_64-linux-gnu arm-linux-gnueabihf aarch64-linux-gnu riscv64-linux-gnu powerpc64-linux-gnu
-#                        x86_64-w64-mingw32
-#                        x86_64-apple-darwin arm64-apple-darwin}"
 export HOSTS="${HOSTS:-x86_64-linux-gnu arm-linux-gnueabihf aarch64-linux-gnu riscv64-linux-gnu powerpc64-linux-gnu
-                       x86_64-w64-mingw32}"
+                       x86_64-w64-mingw32
+                       x86_64-apple-darwin arm64-apple-darwin}"
 
 # Usage: distsrc_for_host HOST
 #
diff --git a/contrib/guix/libexec/build.sh b/contrib/guix/libexec/build.sh
index ad189d591fc5c..ed47af6603f85 100755
--- a/contrib/guix/libexec/build.sh
+++ b/contrib/guix/libexec/build.sh
@@ -284,7 +284,7 @@ mkdir -p "$DISTSRC"
     # Install built Bitcoin Core to $INSTALLPATH
     case "$HOST" in
         *darwin*)
-            make install-strip DESTDIR="${INSTALLPATH}" ${V:+V=1}
+            cmake --install build --strip --prefix "${INSTALLPATH}" ${V:+--verbose}
             ;;
         *)
             cmake --install build --prefix "${INSTALLPATH}" ${V:+--verbose}
@@ -293,13 +293,12 @@ mkdir -p "$DISTSRC"
 
     case "$HOST" in
         *darwin*)
-            make osx_volname ${V:+V=1}
-            make deploydir ${V:+V=1}
+            cmake --build build --target deploy ${V:+--verbose}
+            mv build/dist/Bitcoin-Core.zip "${OUTDIR}/${DISTNAME}-${HOST}-unsigned.zip"
             mkdir -p "unsigned-app-${HOST}"
             cp  --target-directory="unsigned-app-${HOST}" \
-                osx_volname \
                 contrib/macdeploy/detached-sig-create.sh
-            mv --target-directory="unsigned-app-${HOST}" dist
+            mv --target-directory="unsigned-app-${HOST}" build/dist
             (
                 cd "unsigned-app-${HOST}"
                 find . -print0 \
@@ -308,7 +307,6 @@ mkdir -p "$DISTSRC"
                     | gzip -9n > "${OUTDIR}/${DISTNAME}-${HOST}-unsigned.tar.gz" \
                     || ( rm -f "${OUTDIR}/${DISTNAME}-${HOST}-unsigned.tar.gz" && exit 1 )
             )
-            make deploy ${V:+V=1} OSX_ZIP="${OUTDIR}/${DISTNAME}-${HOST}-unsigned.zip"
             ;;
     esac
     (
@@ -389,7 +387,7 @@ mkdir -p "$DISTSRC"
 
     case "$HOST" in
         *mingw*)
-            cp -rf --target-directory=. "${DISTSRC}/contrib/windeploy"
+            cp -rf --target-directory=. contrib/windeploy
             (
                 cd ./windeploy
                 mkdir -p unsigned
diff --git a/depends/Makefile b/depends/Makefile
index f75a1822c045a..6492de79564e5 100644
--- a/depends/Makefile
+++ b/depends/Makefile
@@ -282,6 +282,9 @@ $(host_prefix)/share/toolchain.cmake : toolchain.cmake.in $(host_prefix)/.stamp_
             -e 's|@CPPFLAGS@|$(strip $(host_CPPFLAGS))|' \
             -e 's|@CPPFLAGS_RELEASE@|$(strip $(host_release_CPPFLAGS))|' \
             -e 's|@CPPFLAGS_DEBUG@|$(strip $(host_debug_CPPFLAGS))|' \
+            -e 's|@LDFLAGS@|$(strip $(host_LDFLAGS))|' \
+            -e 's|@LDFLAGS_RELEASE@|$(strip $(host_release_LDFLAGS))|' \
+            -e 's|@LDFLAGS_DEBUG@|$(strip $(host_debug_LDFLAGS))|' \
             -e 's|@no_qt@|$(NO_QT)|' \
             -e 's|@no_qr@|$(NO_QR)|' \
             -e 's|@no_zmq@|$(NO_ZMQ)|' \
diff --git a/depends/toolchain.cmake.in b/depends/toolchain.cmake.in
index 9ff2bbeb51e12..4771d80005efa 100644
--- a/depends/toolchain.cmake.in
+++ b/depends/toolchain.cmake.in
@@ -73,6 +73,16 @@ set(DEPENDS_COMPILE_DEFINITIONS @CPPFLAGS@)
 set(DEPENDS_COMPILE_DEFINITIONS_RELWITHDEBINFO @CPPFLAGS_RELEASE@)
 set(DEPENDS_COMPILE_DEFINITIONS_DEBUG @CPPFLAGS_DEBUG@)
 
+if(NOT DEFINED CMAKE_EXE_LINKER_FLAGS_INIT)
+  set(CMAKE_EXE_LINKER_FLAGS_INIT "@LDFLAGS@")
+endif()
+if(NOT DEFINED CMAKE_EXE_LINKER_FLAGS_RELWITHDEBINFO_INIT)
+  set(CMAKE_EXE_LINKER_FLAGS_RELWITHDEBINFO_INIT "@LDFLAGS_RELEASE@")
+endif()
+if(NOT DEFINED CMAKE_EXE_LINKER_FLAGS_DEBUG_INIT)
+  set(CMAKE_EXE_LINKER_FLAGS_DEBUG_INIT "@LDFLAGS_DEBUG@")
+endif()
+
 set(CMAKE_AR "@AR@")
 set(CMAKE_RANLIB "@RANLIB@")
 set(CMAKE_STRIP "@STRIP@")