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knowledge.html
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<!DOCTYPE html>
<html id="outer-tag" class="scrollContainer" lang="en">
<head>
<!-- Global site tag (gtag.js) - Google Analytics -->
<script async src="https://www.googletagmanager.com/gtag/js?id=UA-112221222-3"></script>
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window.dataLayer = window.dataLayer || [];
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gtag('js', new Date());
gtag('config', 'UA-112221222-3');
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(adsbygoogle = window.adsbygoogle || []).push({
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<title>
HbA1c Converter
</title>
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<p>Knowledge</p>
</div>
<div id="edu_IT" style="display: none">
<p>Sapere</p>
</div>
</a>
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<li class="nav-item">
<a id="forwardInfoLang" class="nav-link">
<i class="now-ui-icons files_paper"></i>
<p>Info</p>
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<div class="container">
<div class="card text-center">
<div class="card-body">
<h4 class="card-title" style="color: black;">
<div class="en">
Info about Glycated Haemoglobin (HbA1c)
</div>
<div class="it">
Informazioni riguardanti l'Emoglobina Glicata (HbA1c)
</div>
</h4>
<p class="card-text">
<div class="en" style="color: black; padding-left: 50px; padding-right: 50px;">
The haemoglobin is a particular protein present on the surface of red blood cells. <br>
Glucose, present in blood at higher concentrations than normoglycemic patients, can links to haemoglobin slowly and continuously within the lifespan of a red blood cell (90/120-day approximately) forming a new protein. (haemoglobin glycosylated)<br>
This new protein (HbA1c) is bulkier and less agile, making it less efficient to transport oxygen and consequently causing a lower oxygenation of the various organs and tissues.
Measuring haemoglobin glycated medical staff is able to have an overall picture of the average blood sugar levels over the lifespan of the red blood cells.<br>
The haemoglobin glycated provides a long-term static trend, in contrast to new metrics (Time-In-Range) of new monitoring techniques (CGMs) that provide a different approach in the evaluation of the clinical performance, exposing the lack of the evaluation of the glycemic variance in previous metrics.<br>
The standard biomarker for assessing the quality and the control of the therapy continues to be the haemoglobin glycated (HbA1c), however nowadays we have new metrics that assess a more accurate clinical profile.
<br><br>
<p>Some interesting readings on the topic:</p>
</div>
<div class="it" style="color: black; padding-left: 50px; padding-right: 50px;">
L'emoglobina è una particolare proteina presente sulla superficie dei globuli rossi.<br>
Il glucosio, presente nel sangue a concentrazioni più elevate rispetto ai pazienti normoglicemici, può legare lentamente all'emoglobina durante la vita di un globulo rosso (circa 90/120 giorni circa) formando una nuova proteina. (emoglobina glicosilata)<br>
Questa nuova proteina (HbA1c) è più ingombrante e meno agile, rendendo meno efficiente il trasporto dell'ossigeno, causando una minore ossigenazione dei vari organi e tessuti.
La misurazione dell'emoglobina glicata consente al personale medico e ai pazienti di avere un quadro generale dei livelli medi di glucosio nel sangue durante il ciclo di vita dei globuli rossi.<br>
L'emoglobina glicata fornisce una visuale statica sul lungo termine, in contrasto alle nuove metriche (Time-In-Range) delle nuove tecniche di monitoraggio (CGM) che forniscono un approccio differito nella valutazione del quadro clinico, marcando la mancanza della valutazione della varianza glicemica nelle metriche precedenti.<br>
Il biomarcatore di riferimento per valutare la qualità della terapia, continua ad essere l'emoglobina glicata (HbA1c), tuttavia oggi abbiamo nuove metriche che permettono di valutare il profilo clinico in modo più accurato.
<br><br>
<p>Alcuni articoli interessanti sull'argomento:</p>
</div>
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819436/" style="color: black;">
Weykamp, Cas. “HbA1c: A Review of Analytical and Clinical Aspects.” Annals of Laboratory Medicine 33.6 (2013): 393–400. PMC. Web. 18 Oct. 2018.</a>
<br><br>
<a href="https://www.diabetes.co.uk/what-is-hba1c.html" style="color: black;">
What is HbA1c?</a>
<br><br>
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444503/" style="color: black;">
Wright LA-C, Hirsch IB. Metrics Beyond Hemoglobin A1C in Diabetes Management: Time in Range, Hypoglycemia, and Other Parameters. Diabetes Technology & Therapeutics. 2017;19(Suppl 2):S-16-S-26. doi:10.1089/dia.2017.0029.</a>
<br><br>
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495532/" style="color: black;">
Rodbard, David. “Evaluating Quality of Glycemic Control: Graphical Displays of Hypo- and Hyperglycemia, Time in Target Range, and Mean Glucose.” Journal of Diabetes Science and Technology 9.1 (2015): 56–62. PMC. Web. 18 Oct. 2018.</a>
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<script>
$(document).ready(function() {
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if(urlLang)
setLanguage(urlLang);
$("#scrollPage").click(function () {
console.info("Also got here");
$('html').animate({
scrollTop: $("#first-block-card").offset().top -100
}, 1500);
});
propagateTranslation();
});
function propagateTranslation(){
var currentLanguageSelector = document.getElementById('languageSelector').innerHTML;
document.getElementById('forwardKnowledgeLang').setAttribute('href', 'knowledge.html#'+currentLanguageSelector);
document.getElementById('forwardInfoLang').setAttribute('href', 'info.html#'+currentLanguageSelector);
document.getElementById('forwardHomeLang').setAttribute('href', 'index.html#'+currentLanguageSelector);
}
function switchChange(cb) {
var inputForm = document.getElementById('input').placeholder;
var outputForm = document.getElementById('output').placeholder;
$('#input').attr('placeholder',outputForm);
$('#output').attr('placeholder',inputForm);
reset();
}
function setLanguage(language) {
$('#outer-tag').attr("lang", language);
//TODO: Improve
//Dirty hack for fixing displaying style in menu
if (language == "it") {
document.getElementById("edu_EN").style.display="none";
document.getElementById("edu_IT").style.display="inline-block";
}else{
document.getElementById("edu_EN").style.display="inline-block";
document.getElementById("edu_IT").style.display="none";
}
var selector = document.getElementById('languageSelector');
selector.innerHTML = language;
propagateTranslation();
}
</script>
</body>
</html>