diff --git a/invesalius/gui/preferences.py b/invesalius/gui/preferences.py
index fa7e6eab2..37ba95cb5 100644
--- a/invesalius/gui/preferences.py
+++ b/invesalius/gui/preferences.py
@@ -92,7 +92,10 @@ def __bind_events(self):
 
     def OnOK(self, event):
         Publisher.sendMessage("Save Preferences")
-        self.EndModal(wx.ID_OK)
+        try:
+            self.EndModal(wx.ID_OK)
+        except wx._core.wxAssertionError:
+            self.Destroy()
 
     def OnCharHook(self, event):
         if event.GetKeyCode() == wx.WXK_ESCAPE: