Error - No operations allowed after connection closed - MySQL?

[kkonrad]

I got in log such message:
error checking ds object: The last packet successfully received from the server was 449,989,888 milliseconds ago. The last packet sent successfully to the server was 449,989,888 milliseconds ago. is longer than the server configured value of 'wait_timeout'. You should consider either expiring and/or testing connection validity before use in your application, increasing the server configured values for client timeouts, or using the Connector/J connection property 'autoReconnect=true' to avoid this problem.

and after it I couldn't send any request because I was getting:
2012-06-06 17:16:14,575 ERROR - error checking ds object: No operations allowed after connection closed.
or:
2012-06-06 17:16:14,582 ERROR - No operations allowed after connection closed.

I was checking it and it is seems like related to MySQL ...