-
Notifications
You must be signed in to change notification settings - Fork 0
/
stroke.html
executable file
·238 lines (199 loc) · 20 KB
/
stroke.html
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
<!doctype html>
<!--[if lt IE 7]> <html class="no-js lt-ie9 lt-ie8 lt-ie7" lang=""> <![endif]-->
<!--[if IE 7]> <html class="no-js lt-ie9 lt-ie8" lang=""> <![endif]-->
<!--[if IE 8]> <html class="no-js lt-ie9" lang=""> <![endif]-->
<!--[if gt IE 8]><!--> <html class="no-js" lang=""> <!--<![endif]-->
<head>
<meta charset="utf-8">
<meta name="description" content="">
<meta name="viewport" content="width=device-width, initial-scale=1">
<title>Stroke and dementia</title>
<link rel="stylesheet" href="css/bootstrap.min.css">
<link rel="stylesheet" href="css/flexslider.css">
<link rel="stylesheet" href="css/main.css">
<link rel="stylesheet" href="css/responsive.css">
<link rel="stylesheet" href="css/animate.min.css">
<link rel="stylesheet" href="https://maxcdn.bootstrapcdn.com/font-awesome/4.4.0/css/font-awesome.min.css">
</head>
<body>
<!-- Header Section -->
<section class="tophead" role="tophead">
<!-- Navigation Section -->
<header id="header">
<div class="header-content clearfix"> <a class="logo" href="index.html">Stroke and dementia</a>
<nav class="navigation" role="navigation">
<ul class="primary-nav">
<li><a href="papers.html">Publications</a></li>
<li><a href="talks.html">Presentations</a></li>
<li><a href="projects.html">Projects</a></li>
<li><a href="https://doi.org/10.6084/m9.figshare.5787327.v1">Doctorate</a></li>
<li><a href="index.html#header-slider">Home</a></li>
</ul>
</nav>
<a href="#" class="nav-toggle">Menu<span></span></a> </div>
</header>
<!-- Navigation Section -->
</section>
<!-- Header Section -->
<!-- Altmetrics -->
<script type='text/javascript' src='https://d1bxh8uas1mnw7.cloudfront.net/assets/embed.js'></script>
<!-- Altmetrics -->
<!-- projects section -->
<section id="projects-detail" class="section projects-detail">
<div class="container-fluid">
<div class="row">
<div class="col-md-4 projects-detail-margin detail-image">
<div class="projects-image">
<p> <img src="images/portfolio/maps.png"></p>
<p> <img src="images/portfolio/MRS.png"></p>
</div>
</div>
<div class="col-md-8 projects-detail-margin detail-contentbox">
<div class="detail-content">
<h5>CLINICAL STUDIES</h5>
<ol>
<li>
<b> Oxford Cognitive Comorbidity and Ageing Research (ORCHARD).</b> A cohort study aiming to identify older hospital patients at high short-term risk of dementia and cognitive decline using routinely collected hospital electronic clinical and brain imaging data to improve care. Funded by NIHR i4i programme grant (NIHR 204290) on which I am a co-applicant.
<a href="https://www.ndcn.ox.ac.uk/research/orchard-study"> Study website </a>
<a href="https://www.ndcn.ox.ac.uk/research/orchard-study"><i class="fa fa-newspaper-o"></i></a>;
<a href="https://fundingawards.nihr.ac.uk/award/NIHR204290"> NIHR website </a>
<a href="https://fundingawards.nihr.ac.uk/award/NIHR204290"><i class="fa fa-newspaper-o"></i></a>.
</li>
<li> <b>Oxford Haemodynamic Adaptation to Reduce Pulsatility trial (OxHARP). </b> A double-cross-over placebo controlled randomised clinical trial on the effects of two phosphodiesterase inhibitors (Sildenafil and Cilostasol) on cerebrovascular reactivity and the pulsatility of cerebral blood flow. Funded by Wellcome Trust.
<a href="https://clinicaltrials.gov/ct2/show/NCT03855332?term=NCT03855332&draw=2&rank=1">ClinicalTrials.gov: NCT03855332</a>
<a href="https://clinicaltrials.gov/ct2/show/NCT03855332?term=NCT03855332&draw=2&rank=1"><i class="fa fa-pencil-square-o"></i></a>;
<a href="https://journals.sagepub.com/doi/10.1177/23969873211026698"> Protocol </a>
<a href="https://journals.sagepub.com/doi/10.1177/23969873211026698"><i class="fa fa-file-text-o"></i></a>;
<a href="https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.124.324327"> Results </a>
<a href="https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.124.324327"><i class="fa fa-file-text-o"></i></a>
</li>
<li>
<b> Effects of Amlodipine and Other Blood Pressure Lowering Agents on Microvascular Function trial (TREAT@SVDs).</b>
A phase three cross-over trial of the effects of three commonly used anti-hypertensives (Amlodipine, Losartan, Atenolol) on endothelial function and cerebrovascular reactivity. Funded by the European Union’s Horizon 2020 programme.
<a href="https://clinicaltrials.gov/study/NCT03082014?cond=Small%20Vessel%20Disease&term=TREAT&rank=1">ClinicalTrials.gov: NCT03082014</a>
<a href="https://clinicaltrials.gov/study/NCT03082014?cond=Small%20Vessel%20Disease&term=TREAT&rank=1"><i class="fa fa-pencil-square-o"></i></a>;
<a href="https://doi.org/10.1177/23969873221143"> Protocol </a>
<a href="https://doi.org/10.1177/23969873221143"><i class="fa fa-file-text-o"></i></a>;
<a href="https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(23)00293-4/abstract?rss=yes"> Results </a>
<a href="https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(23)00293-4/abstract?rss=yes"><i class="fa fa-file-text-o"></i></a>
</li>
<li>
<b> Oxford Vascular Study (OxVASC).</b> A cohort study of people at risk of stroke and vascular dementia.
<a href="https://www.ndcn.ox.ac.uk/research/oxvasc"> Study website </a>
<a href="https://www.ndcn.ox.ac.uk/research/oxvasc"><i class="fa fa-newspaper-o"></i></a>.
</li>
<li>
<b> Arterial Pulsatility in Small Vessel Diseases – Measurement of Arterial Pulsatility on MRI (OxBP).</b> A sub-study of the TREAT@SVDs trial investigating the effects of vasodilators on cerebral pulsatility.
</li>
</ol>
<br>
<h5>PUBLICATIONS</h5>
<ol>
<li>
<div> Webb AJS, Birks J, <b>Feakins KA</b>, Lawson A, Dawson J, Rothman AMK, Werring JD, Llwyd O, Stewart C, Thomas J.
<a href="https://doi.org/10.1161/CIRCRESAHA.124.324327"> Cerebrovascular Effects of Sildenafil in Small Vessel Disease: The OxHARP Trial. </a><i>Circulation Research</i> 2024 Publication ahead of print.</div>
<div data-badge-popover="right" data-badge-type="2" data-doi="10.1161/CIRCRESAHA.124.324327" data-hide-no-mentions="true" class="altmetric-embed"></div>
</li>
<li>
<div> Kopczak A, Stringer MS, van den Brink H, Kerkhofs D, Blair GW, van Dinther M, Reyes CA, Garcia DJ, Onkenhout L, <b>Wartolowska KA</b>, Thrippleton MJ, Kampaite A, Duering M, Staals J, Lesnik-Oberstein S, Muir KW, Middeke M, Norrving B, Bousser MG, Mansmann U, Rothwell PM, Doubal FN, van Oostenbrugge R, Biessels GJ, Webb AJS, Wardlaw JM, Dichgans M; TREAT-SVDs collaborators.
<a href="https://doi.org/10.1016/S1474-4422(23)00293-4"> Effect of blood pressure-lowering agents on microvascular function in people with small vessel diseases (TREAT-SVDs): a multicentre, open-label, randomised, crossover trial. </a><i>Lancet Neurology </i> 2023;22:991-1004.</div>
<div data-badge-popover="right" data-badge-type="2" data-doi="10.1016/S1474-4422(23)00293-4" data-hide-no-mentions="true" class="altmetric-embed"></div>
</li>
<li>
<div> Kopczak A, Stringer M, van den Brink H, Kerkhofs D, Blair GW, van Dinther M, Onkenhout L, <b>Wartolowska KA</b>, Thrippleton MJ, Duering M, Staals J, Middeke M, André E, Norrving B, Bousser M-G, Mansmann U, Rothwell PM, Doubal FN, van Oostenbrugge R, Biessels GJ, Webb AJS, Wardlaw JM, Dichgans M, on behalf of the SVDs@target consortium.
<a href="https://doi.org/10.1177/23969873221143570"> The EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases (TREAT-SVDs) trial: Study protocol for a randomised crossover trial. </a><i>European Stroke Journal</i> 2022;8:387-397.</div>
<div data-badge-popover="right" data-badge-type="2" data-doi="10.1177/23969873221143570" data-hide-no-mentions="true" class="altmetric-embed"></div>
</li>
<li>
<div> Webb AJS, <b>Wartolowska KA</b>, Li L, Mazzucco S, Rothwell PM. <a href="https://doi.org/10.1159/000525764"> Consistencies and differences in intermediate physiological phenotypes of vascular ageing between ischaemic stroke aetiologies. </a><i>Cerebrovascular Diseases</i> 2023;52(2):194-201. </div>
<div data-badge-popover="right" data-badge-type="2" data-doi="10.1159/000525764" data-hide-no-mentions="true" class="altmetric-embed"></div>
</li>
<li>
<div> Webb AJS, <b>Wartolowska KA</b>, Li L, Rothwell PM. <a href="https://doi.org/10.1002/ana.26480"> Low heart rate is associated with cerebral pulsatility after TIA or minor stroke. </a><i>Annals of Neurology</i> 2022;92:909-920. </div>
<div data-badge-popover="right" data-badge-type="2" data-doi="10.1002/ana.26480" data-hide-no-mentions="true" class="altmetric-embed"></div>
</li>
<li>
<div><b>Wartolowska KA</b>, Webb AJS. <a href="https://journals.sagepub.com/doi/abs/10.1177/0271678X211058803?ai=2b4&mi=ehikzz&af=R"> White matter damage due to pulsatile versus steady blood pressure differs by vascular territory: a cross-sectional analysis of the UK Biobank cohort study. </a><i>Journal of Cerebral Blood Flow and Metabolism</i> 2021;6:283-290. </div>
<div data-badge-popover="right" data-badge-type="2" data-doi="10.1177/0271678X211058803" data-hide-no-mentions="true" class="altmetric-embed"></div>
</li>
<li>
<div>Webb AJS, Lawson A, <b>Wartolowska KA</b>, Mazzucco S, Rothwell PM. <a href="https://doi.org/10.1161/STROKEAHA.121.035560"> Aortic stiffness, pulse pressure and cerebral pulsatility progress despite best medical management: the OxVASC cohort. </a><i>Stroke</i> 2022;53:1310–1317.</div>
<div data-badge-popover="right" data-badge-type="2" data-doi="10.1161/STROKEAHA.121.035560" data-hide-no-mentions="true" class="altmetric-embed"></div>
</li>
<li>
<div><b>Wartolowska KA</b>, Webb AJS. <a href="https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehab566/6364085"> Big cohort studies offer insights into preventable risk factors. </a><i>European Heart Journal</i> 2021;42:4280–4281. </div>
<div data-badge-popover="right" data-badge-type="2" data-doi="10.1093/eurheartj/ehab566" data-hide-no-mentions="true" class="altmetric-embed"></div>
</li>
<li>
<div>Webb AJS, Werring D, Dawson J, Rothman A, Lawson A, <b>Wartolowska K</b>. <a href="https://journals.sagepub.com/doi/10.1177/23969873211026698"> Design of a randomised, double-blind, crossover, placebo-controlled trial of effects of sildenafil on cerebrovascular function in small vessel disease: Oxford Haemodynamic Adaptation to Reduce Pulsatility Trial (OxHARP). </a><i>European Stroke Journal</i> 2021;6:283–290 </div>
<div data-badge-popover="right" data-badge-type="2" data-doi="10.1177/23969873211026698" data-hide-no-mentions="true" class="altmetric-embed"></div>
</li>
<li>
<div><b>Wartolowska KA</b>, Webb AJS. <a href="https://doi.org/10.1161/HYPERTENSIONAHA.121.17403"> Blood pressure determinants of cerebral white matter hyperintensities and microstructural injury: UK Biobank cohort study.</a> <i>Hypertension</i> 2021;78:532-539.</div>
<div data-badge-popover="right" data-badge-type="2" data-doi="10.1161/HYPERTENSIONAHA.121.17403" data-hide-no-mentions="true" class="altmetric-embed"></div>
</li>
<li>
<div>Webb AJS, Lawson A, <b>Wartolowska KA</b>, Mazzucco S, Peter M Rothwell PM. <a href="https://doi.org/10.1161/HYPERTENSIONAHA.120.16290"> Progression of Beat-to-Beat Blood Pressure Variability Despite Best Medical Management.</a> <i>Hypertension</i> 2021;77:193-201 </div>
<div data-badge-popover="right" data-badge-type="2" data-doi="10.1161/HYPERTENSIONAHA.120.16290" data-hide-no-mentions="true" class="altmetric-embed"></div>
</li>
<li>
<div><b>Wartolowska KA</b>, Webb AJS. <a href="https://doi.org/10.1093/eurheartj/ehaa756"> Midlife blood pressure is associated with the severity of white matter hyperintensities: analysis of the UK Biobank cohort study. </a><i> European Heart Journal </i> 2021; 42(7): 750–757. </div>
<div data-badge-popover="right" data-badge-type="2" data-doi="10.1093/eurheartj/ehaa756" data-hide-no-mentions="true" class="altmetric-embed"></div>
</li>
</li>
<li>
<div>Karaszewski B, Wardlaw JM, Marshall I, Cvoro V, <b>Wartolowska K</b>, Haga K, Armitage PA, Bastin ME, Dennis MS. <a href="https://dx.doi.org/10.1093/brain/awp010">Early brain temperature elevation and anaerobic metabolism in human acute ischaemic stroke. </a><i>Brain</i> 2009;32:955-964 </div>
<div data-badge-popover="right" data-badge-type="2" data-doi="10.1093/brain/awp010" data-hide-no-mentions="true" class="altmetric-embed"></div>
</li>
<li>
<div>Cvoro V, Wardlaw JM, Marshall I, Armitage PA, Rivers CS, Bastin ME, Carpenter TK, <b>Wartolowska K</b>, Farrall AJ, Dennis MS. <a href="https://dx.doi.org/10.1161/STROKEAHA.108.525626"> Associations between diffusion and perfusion parameters, N-acetyl aspartate, and lactate in acute ischemic stroke. </a><i>Stroke</i> 2009;40:767-772 </div>
<div data-badge-popover="right" data-badge-type="2" data-doi="10.1161/STROKEAHA.108.525626" data-hide-no-mentions="true" class="altmetric-embed"></div>
</li>
<li>
<div>Karaszewski B, Wardlaw JM, Marshall I, Cvoro V, <b>Wartolowska K</b>, Haga K, Armitage PA, Bastin ME, Dennis MS. <a href="http://dx.doi.org/10.1002/ana.20957"> Measurement of brain temperature with magnetic resonance spectroscopy in acute ischemic stroke. </a><i> Annals of Neurology</i> 2006;60:438-446 </div>
<div data-badge-popover="right" data-badge-type="2" data-doi="10.1002/ana.20957" data-hide-no-mentions="true" class="altmetric-embed"></div>
</li>
<li>
<div>Marshall I, Karaszewski B, Wardlaw JM, Cvoro V, <b>Wartolowska K</b>, Armitage PA, Carpenter T, Bastin ME, Farrall A, Haga K. <a href="http://dx.doi.org/10.1016/j.mri.2006.02.002">Measurement of regional brain temperature using proton spectroscopic imaging: validation and application to acute ischemic stroke. </a> <i>Magnetic Resonance Imaging</i> 2006;24:699-706 </div>
<div data-badge-popover="right" data-badge-type="2" data-doi="10.1016/j.mri.2006.02.002" data-hide-no-mentions="true" class="altmetric-embed"></div>
</li>
<li>
<div>Wardlaw JM, Chappell FM, Best JJ, <b>Wartolowska K</b>, Berry E. NHS Research and Development Health Technology Assessment Carotid Stenosis Imaging Group. <a href="http://dx.doi.org/10.1016/S0140-6736(06)68650-9"> Non-invasive imaging compared with intra-arterial angiography in the diagnosis of symptomatic carotid stenosis: a meta-analysis. </a><i> Lancet </i> 2006;367:1503-1512 </div>
<div data-badge-popover="right" data-badge-type="2" data-doi="10.1016/S0140-6736(06)68650-9" data-hide-no-mentions="true" class="altmetric-embed"></div>
</li>
<li>
<div>Marshall I, Papathanasopoulou P, <b>Wartolowska K</b>. <a href="http://dx.doi.org/10.1088/0967-3334/25/3/009"> Carotid flow rates and flow division at the bifurcation in healthy volunteers. </a><i> Physiological Measurement</i> 2004;25:691-697 </div>
<div data-badge-popover="right" data-badge-type="2" data-doi="10.1088/0967-3334/25/3/009" data-hide-no-mentions="true" class="altmetric-embed"></div>
</li>
</ol>
<br>
<h5>CONFERENCE PRESENTATIONS</h5>
<ol>
<li> <b>Wartolowska K</b> and Webb AJS. Regional diffusion imaging changes related to obesity, after adjusting for other risk factors: the UK Biobank study.<i> The 31th ISMRM Conference</i>. London, UK. 2020. <a href="./pdfs/ISMRM_2022.pdf"><i class="fa fa-file-pdf-o"></i></a></li>
<li> <b>Wartolowska K</b> and Webb AJS. Complex interactions between obesity and white matter: UK Biobank study. <i>European Stroke Organisation Conference.</i> Virtual due to COVID. 2021. <a href="./pdfs/ESOC-2021.pdf"><i class="fa fa-file-pdf-o"></i></a></li>
<li> <b>Wartolowska K</b> and Webb AJS. Effect of past and concurrent blood pressure above 120/70 on white matter hyperintensities: an analysis of the UK Biobank cohort. <i>European Stroke Organisation-World Stroke Organisation Conference.</i> Virtual due to COVID. 2021.<a href="./pdfs/ESO_WMH_2020.pdf"><i class="fa fa-file-pdf-o"></i></a></li>
<li> <b>Wartolowska K</b> and Webb AJS. Differential associations between macroscopic and microstructural white matter injury with constant and pulsatile blood pressure components: an analysis of the UK Biobank cohort. <i>European Stroke Organisation-World Stroke Organisation Virtual Conference.</i> Virtual due to COVID. 2020. <a href="./pdfs/ESO_DTI_2020.pdf"><i class="fa fa-file-pdf-o"></i></a></li>
<li> Croal PL, Ray KJ, <b>Wartolowska K</b>, Lawson A, Webb A, Jezzard P. Physiological correlates of brain pulsatility in cerebrovascular small vessel disease: a data-driven approach with high temporal resolution fMRI. <i>ISMRM & SMRT Virtual Conference & Exhibition. 2020. </i> </li>
<li> <b>Wartolowska K</b> and Webb AJS. Mid-life diastolic blood pressure predicts excess future white matter hyperintensities more than systolic blood pressure: an analysis of the UK Biobank cohort. <i>The Brain Prize Meeting: “Silently Loosing the Brain”. The Lundbeck Foundation.</i> Copenhagen, Denmark. 2019. </li>
<li> Cvoro V, Wardlaw JM, <b>Wartolowska K </b>, Farrall AJ, Marshall I, Armitage PA, Rivers CS, Bastin ME, Carpenter TK, Dennis MS. Lactate values in the acute stroke diffusion lesion vary with perfusion levels <i>The 15th European Stroke Conference </i> Brussels, Belgium. 2006.</li>
<li> Wardlaw JM, Karaszewski BC, Marshall I, Cvoro V, <b>Wartolowska K </b>, Haga K, Armitage PA, Bastin ME. Dennis MS. Measurement of brain temperature with MR spectroscopy in patients with acute ischaemic stroke - temperature is highest in "penumbral" tissue <i> British Society of Neuroradiologists Annual Scientific Meeting </i> Edinburgh, UK. 2005.</li>
<li> Marshall I, Karaszewski B, Wardlaw JM, Cvoro V, <b>Wartolowska K </b>, Armitage PA, Carpenter T, Bastin M, Farrall A, Haga K, Dennis M. Measurement of regional brain temperature using proton spectroscopic imaging: preliminary results in acute ischaemic stroke <i>European Society for Magnetic Resonance in Medicine and Biology (ESMRMB) Conference</i>, Basel Switzerland. 2005.</li><br>
</ol>
</p>
<!--<a class="btn" href="stroke.html"><i class="fa fa-long-arrow-left"></i>Previous</a>
<a class="btn" href="index.html">Home<i class="#"></i></a>
<a class="btn" href="placebo.html">Next<i class="fa fa-long-arrow-right"></i></a>-->
</div>
</div>
</div>
</section>
<!-- work details section -->
<!-- JS FILES -->
<script src="https://ajax.googleapis.com/ajax/libs/jquery/1.11.3/jquery.min.js"></script>
<script src="js/bootstrap.min.js"></script>
<script src="js/jquery.flexslider-min.js"></script>
<script src="js/retina.min.js"></script>
<script src="js/modernizr.js"></script>
<script src="js/main.js"></script>
</body>
</html>