diff --git a/src/knowledge_base/config.py b/src/knowledge_base/config.py
index de6616c..499fc00 100644
--- a/src/knowledge_base/config.py
+++ b/src/knowledge_base/config.py
@@ -94,6 +94,10 @@ class Settings(BaseSettings):
     NEO4J_URI: str = "bolt://localhost:7687"
     NEO4J_USER: str = "neo4j"
     NEO4J_PASSWORD: str = ""
+    # Neo4j connection pool resilience (seconds)
+    NEO4J_LIVENESS_CHECK_TIMEOUT: int = 30  # Check connection health before use
+    NEO4J_MAX_CONNECTION_LIFETIME: int = 1800  # Recycle connections every 30 min
+    NEO4J_CONNECTION_ACQUISITION_TIMEOUT: int = 60  # Wait up to 60s for a connection
     # Feature flags for Graphiti-only architecture
     GRAPH_ENABLE_GRAPHITI: bool = True  # Master switch for Graphiti (now required)
     GRAPH_EXPANSION_ENABLED: bool = True  # Always enabled with Graphiti-only
diff --git a/src/knowledge_base/graph/graphiti_client.py b/src/knowledge_base/graph/graphiti_client.py
index 63eed71..88d667f 100644
--- a/src/knowledge_base/graph/graphiti_client.py
+++ b/src/knowledge_base/graph/graphiti_client.py
@@ -7,6 +7,7 @@
 NetworkX-based graph during the gradual rollout phase.
 """
 
+import asyncio
 import logging
 import os
 from typing import TYPE_CHECKING
@@ -38,6 +39,7 @@ class GraphitiClient:
 
     _instance: "Graphiti | None" = None
     _initialized: bool = False
+    _init_lock: asyncio.Lock | None = None
 
     def __init__(
         self,
@@ -68,6 +70,9 @@ def __init__(
     async def get_client(self) -> "Graphiti":
         """Get or create the Graphiti client instance.
 
+        Uses an asyncio.Lock to prevent concurrent initialization from
+        multiple async tasks creating duplicate Graphiti instances.
+
         Returns:
             Configured Graphiti instance
 
@@ -78,22 +83,31 @@ async def get_client(self) -> "Graphiti":
         if GraphitiClient._instance is not None and GraphitiClient._initialized:
             return GraphitiClient._instance
 
-        try:
-            if self.backend == "kuzu":
-                client = await self._create_kuzu_client()
-            elif self.backend == "neo4j":
-                client = await self._create_neo4j_client()
-            else:
-                raise GraphitiClientError(f"Unsupported graph backend: {self.backend}")
+        # Lazy-init the lock (safe: first call always happens in a single task)
+        if GraphitiClient._init_lock is None:
+            GraphitiClient._init_lock = asyncio.Lock()
 
-            GraphitiClient._instance = client
-            GraphitiClient._initialized = True
-            logger.info(f"Graphiti client initialized with {self.backend} backend")
-            return client
+        async with GraphitiClient._init_lock:
+            # Double-check after acquiring lock
+            if GraphitiClient._instance is not None and GraphitiClient._initialized:
+                return GraphitiClient._instance
 
-        except Exception as e:
-            logger.error(f"Failed to initialize Graphiti client: {e}")
-            raise GraphitiConnectionError(f"Could not connect to {self.backend}: {e}") from e
+            try:
+                if self.backend == "kuzu":
+                    client = await self._create_kuzu_client()
+                elif self.backend == "neo4j":
+                    client = await self._create_neo4j_client()
+                else:
+                    raise GraphitiClientError(f"Unsupported graph backend: {self.backend}")
+
+                GraphitiClient._instance = client
+                GraphitiClient._initialized = True
+                logger.info(f"Graphiti client initialized with {self.backend} backend")
+                return client
+
+            except Exception as e:
+                logger.error(f"Failed to initialize Graphiti client: {e}")
+                raise GraphitiConnectionError(f"Could not connect to {self.backend}: {e}") from e
 
     async def _create_kuzu_client(self) -> "Graphiti":
         """Create Graphiti client with Kuzu embedded backend."""
@@ -136,10 +150,34 @@ async def _create_kuzu_client(self) -> "Graphiti":
     async def _create_neo4j_client(self) -> "Graphiti":
         """Create Graphiti client with Neo4j backend."""
         from graphiti_core import Graphiti
+        from graphiti_core.driver.neo4j_driver import Neo4jDriver
+        from neo4j import AsyncGraphDatabase
 
         if not self.neo4j_password:
             raise GraphitiClientError("NEO4J_PASSWORD is required for Neo4j backend")
 
+        # Create Neo4j driver with connection pool resilience settings
+        # Default driver has liveness_check_timeout=None (disabled), which causes
+        # stale connections to fail with "TCPTransport closed" after Neo4j restarts
+        # or long idle periods (e.g. during multi-hour pipeline intake runs)
+        neo4j_async_driver = AsyncGraphDatabase.driver(
+            self.neo4j_uri,
+            auth=(self.neo4j_user, self.neo4j_password),
+            liveness_check_timeout=settings.NEO4J_LIVENESS_CHECK_TIMEOUT,
+            max_connection_lifetime=settings.NEO4J_MAX_CONNECTION_LIFETIME,
+            connection_acquisition_timeout=settings.NEO4J_CONNECTION_ACQUISITION_TIMEOUT,
+        )
+
+        # Create Neo4jDriver wrapper and inject our configured async driver
+        neo4j_driver = Neo4jDriver(
+            uri=self.neo4j_uri,
+            user=self.neo4j_user,
+            password=self.neo4j_password,
+        )
+        # Replace the default driver with our configured one
+        await neo4j_driver.client.close()
+        neo4j_driver.client = neo4j_async_driver
+
         # Create LLM client for entity extraction
         llm_client = self._get_llm_client()
 
@@ -149,11 +187,9 @@ async def _create_neo4j_client(self) -> "Graphiti":
         # Create cross encoder for reranking
         cross_encoder = self._get_cross_encoder()
 
-        # Create Graphiti instance with Neo4j (uses default Neo4j driver)
+        # Create Graphiti instance with our pre-configured Neo4j driver
         graphiti = Graphiti(
-            uri=self.neo4j_uri,
-            user=self.neo4j_user,
-            password=self.neo4j_password,
+            graph_driver=neo4j_driver,
             llm_client=llm_client,
             embedder=embedder,
             cross_encoder=cross_encoder,