my.cnf

[client]
port = 3306
socket = /home/mysql/data/mysql.sock

[mysql]
prompt = [\\u@\\h][\\d]>\\_
default-character-set = utf8mb4

[mysqld]
read_only = 1
large-pages
basedir	= /usr/local/mysql
datadir	= /home/mysql/data
sql-mode =NO_ENGINE_SUBSTITUTION,STRICT_TRANS_TABLES
lower_case_table_names = 1
log-bin-trust-function-creators	= 1
character-set-server = utf8mb4
collation-server = utf8mb4_unicode_ci
init_connect = 'SET NAMES utf8mb4'
explicit_defaults_for_timestamp = 1
max_allowed_packet = 16M

# connection #
open-files-limit = 65535
port = 3306
socket = /home/mysql/data/mysql.sock
pid-file = /home/mysql/data/mysql.pid
interactive_timeout = 300
wait_timeout = 300
lock_wait_timeout = 10
skip-name-resolve = 1
max_connections = 1000
max_connect_errors = 1000000

# session memory setting #
read_buffer_size = 8M
read_rnd_buffer_size = 4M
sort_buffer_size = 8M
tmp_table_size = 16M
max_heap_table_size = 16M
join_buffer_size = 16M

# log settings #
log_error_verbosity = 3
log-error = /home/mysql/data/mysqld.log
slow-query-log = 1
log-output = FILE
slow_query_log_file = /home/mysql/data/slow.log
log-queries-not-using-indexes = 1
log_slow_admin_statements = 1
log_slow_slave_statements = 1
log_throttle_queries_not_using_indexes = 10
expire_logs_days = 60
long_query_time = 1
log-slave-updates = 1
#general-log = 1
#general_log_file = /home/mysql/data/query.log

# innodb settings #
innodb_page_size = 16K
innodb_buffer_pool_size = 30G
innodb_buffer_pool_instances = 6
innodb_buffer_pool_load_at_startup = 1
innodb_buffer_pool_dump_at_shutdown = 1
innodb_lru_scan_depth = 1024
innodb_lock_wait_timeout = 5
innodb_io_capacity = 1000
innodb_io_capacity_max = 2000
innodb_undo_logs = 128
innodb_undo_tablespaces = 6
innodb_flush_neighbors = 0
innodb_log_file_size = 512M
innodb_log_files_in_group = 8
innodb_log_buffer_size = 16M
innodb_purge_threads = 4
innodb_large_prefix = 1
innodb_print_all_deadlocks = 1
innodb_strict_mode = 1
innodb_sort_buffer_size = 64M
innodb_write_io_threads = 8
innodb_read_io_threads = 8 
innodb_file_per_table = 1
innodb_stats_persistent_sample_pages = 20

# replication setting #
server-id = 220
master_info_repository = TABLE
relay_log_info_repository = TABLE
relay_log_recovery = 1
sync_binlog = 1
gtid-mode = on
enforce_gtid_consistency = 1
log-slave-updates
log-bin	= /apps/logs/mysql_bin/mysql-bin
log_bin_index = /apps/logs/mysql_bin/mysql-bin.index
binlog-format = ROW
binlog_rows_query_log_events = 1
max_binlog_size = 1G
binlog_cache_size = 16M 
max_binlog_cache_size = 4G
relay-log = /home/mysql/data/mysql_relay/mysql-relay-bin
relay-log-index = /home/mysql/data/mysql_relay/mysql-relay.index
binlog_gtid_simple_recovery = 1
slave_skip_errors = ddl_exist_errors
slave-rows-search-algorithms = 'INDEX_SCAN,HASH_SCAN'

# semi sync replication settings #
plugin_load = "rpl_semi_sync_master=semisync_master.so;rpl_semi_sync_slave=semisync_slave.so"
rpl_semi_sync_master_enabled = 1
rpl_semi_sync_master_timeout = 2000
rpl_semi_sync_slave_enabled = 1

[mysqld-5.7]
#innodb_numa_interleave = 1
innodb_buffer_pool_dump_pct = 40
innodb_page_cleaners = 16
innodb_undo_log_truncate = 1
innodb_max_undo_log_size = 2G
innodb_purge_rseg_truncate_frequency = 128
slave-parallel-type = LOGICAL_CLOCK
slave-parallel-workers = 8
slave_preserve_commit_order = 1
slave_transaction_retries=128
#binlog_gtid_simple_recovery=1
log_timestamps = system
#performance_schema=OFF
performance_schema=1

# percona advices #
thread_cache_size = 40
table_definition_cache = 4096
table_open_cache = 1000
innodb_flush_method  = O_DIRECT
key-buffer-size = 32M