diff --git a/.github/workflows/coverage.yml b/.github/workflows/coverage.yml
index ce0bb21bae..c37bbec630 100644
--- a/.github/workflows/coverage.yml
+++ b/.github/workflows/coverage.yml
@@ -37,15 +37,27 @@ jobs:
     env:
       DISPLAY: ${{ ':0' }}
       MUSIC_INSTALL_DIR: /opt/MUSIC
-      MUSIC_VERSION: 1.2.0
+      MUSIC_VERSION: 1.2.1
 
     steps:
 
       - name: Install apt packages
         run: |
-          sudo apt-get install xfonts-100dpi build-essential doxygen lcov libboost-all-dev libopenmpi-dev libmpich-dev libx11-dev libxcomposite-dev mpich openmpi-bin gpg ninja-build flex bison libfl-dev
+          sudo apt-get install xfonts-100dpi build-essential doxygen lcov libboost-all-dev libmpich-dev libx11-dev libxcomposite-dev mpich gpg ninja-build flex bison libfl-dev
         shell: bash
 
+      - name: Install a new version of OpenMPI
+        # The version of OpenMPI on Ubuntu 22.04 does not support MPI 4 features, so we install it manually
+        run: |
+          sudo apt-get purge -y libopenmpi-dev openmpi-bin
+          curl -L -o openmpi.tar.gz https://download.open-mpi.org/release/open-mpi/v5.0/openmpi-5.0.5.tar.gz
+          tar -xf openmpi.tar.gz
+          cd openmpi-5.0.5/
+          ./configure --prefix=/usr/
+          make -j
+          sudo make -j install
+        working-directory: ${{runner.temp}}
+
       - name: Setup Caliper profiler
         run: |
           git clone https://github.com/LLNL/Caliper.git
@@ -58,7 +70,7 @@ jobs:
         run: |
           python3 -m venv music-venv
           source music-venv/bin/activate
-          python3 -m pip install 'mpi4py<4' cython numpy setuptools
+          python3 -m pip install mpi4py cython numpy setuptools
           sudo mkdir -p $MUSIC_INSTALL_DIR
           sudo chown -R $USER $MUSIC_INSTALL_DIR
           curl -L -o MUSIC.zip https://github.com/INCF/MUSIC/archive/refs/tags/${MUSIC_VERSION}.zip
diff --git a/.github/workflows/neuron-ci.yml b/.github/workflows/neuron-ci.yml
index dfe8a9327c..0c731d70b6 100644
--- a/.github/workflows/neuron-ci.yml
+++ b/.github/workflows/neuron-ci.yml
@@ -187,6 +187,18 @@ jobs:
           python -m pip install --upgrade -r ci_requirements.txt
           python -m pip install --upgrade pip -r nrn_requirements.txt
 
+      - name: Install a new version of OpenMPI
+        # The version of OpenMPI on Ubuntu 22.04 does not support MPI 4 features, so we install it manually
+        run: |
+          sudo apt-get purge -y libopenmpi-dev openmpi-bin
+          curl -L -o openmpi.tar.gz https://download.open-mpi.org/release/open-mpi/v5.0/openmpi-5.0.5.tar.gz
+          tar -xf openmpi.tar.gz
+          cd openmpi-5.0.5/
+          ./configure --prefix=/usr/
+          make -j
+          sudo make -j install
+        working-directory: ${{runner.temp}}
+
       - name: Install a new automake
         # A automake >= 1.16.5 is needed for python 3.12 because it generates a python script
         # called py-compile and the original one is not supporting this version of python
@@ -207,7 +219,7 @@ jobs:
         run: |
           python3 -m venv music-venv
           source music-venv/bin/activate
-          python3 -m pip install 'mpi4py<4' cython numpy setuptools
+          python3 -m pip install mpi4py cython numpy setuptools
           sudo mkdir -p $MUSIC_INSTALL_DIR
           sudo chown -R $USER $MUSIC_INSTALL_DIR
           curl -L -o MUSIC.zip https://github.com/INCF/MUSIC/archive/refs/tags/${MUSIC_VERSION}.zip
diff --git a/nrn_requirements.txt b/nrn_requirements.txt
index 1de5573095..e60aeadc03 100644
--- a/nrn_requirements.txt
+++ b/nrn_requirements.txt
@@ -8,6 +8,6 @@ cython
 packaging
 pytest<=8.1.1 # potential bug from 8.2.0 due to parallelism?
 pytest-cov
-mpi4py<4 # MUSIC not compatible with MPI 4
+mpi4py
 numpy
 find_libpython
diff --git a/setup.py b/setup.py
index e15b6e5ac0..fffb2bfec8 100644
--- a/setup.py
+++ b/setup.py
@@ -96,7 +96,7 @@ class Components:
     Components.MUSIC = True
     sys.argv.remove("--enable-music")
 
-if Components.RX3D:
+if Components.RX3D or Components.MUSIC:
     try:
         from Cython.Distutils import Extension as CyExtension
         from Cython.Distutils import build_ext