Robuster robust normalization

[oesteban]

Consider using MCD (http://scikit-learn.org/stable/auto_examples/covariance/plot_robust_vs_empirical_covariance.html) to calculate the sitewise location and spread of features.

(Also worth looking at https://arxiv.org/abs/1707.09752 for alternative ideas)

[oesteban]

Alternatively/additionally, we could use https://arxiv.org/abs/1601.07251 to identify deviating data cells, and mask those out of the parameter estimation in the robust sitewise normalization.

[stale]

This issue has been automatically marked as stale because it has not had recent activity. It will be closed if no further activity occurs. Thank you for your contributions.

[stale]

This issue has been automatically marked as stale because it has not had recent activity. It will be closed if no further activity occurs. Thank you for your contributions.