-
Notifications
You must be signed in to change notification settings - Fork 0
/
poster.html
489 lines (458 loc) · 14.3 KB
/
poster.html
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
<!DOCTYPE html>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<meta charset="utf-8" />
<meta http-equiv="Content-Type" content="text/html; charset=utf-8"/>
<meta name="generator" content="pandoc" />
<meta name="viewport" content="width=device-width, initial-scale=1">
<!--
Font-awesome icons ie github or twitter
-->
<link rel="stylesheet" href="https://use.fontawesome.com/releases/v5.8.1/css/all.css" integrity="sha384-50oBUHEmvpQ+1lW4y57PTFmhCaXp0ML5d60M1M7uH2+nqUivzIebhndOJK28anvf" crossorigin="anonymous">
<link rel="stylesheet" href="https://use.fontawesome.com/releases/v5.8.1/css/brands.css" integrity="sha384-n9+6/aSqa9lBidZMRCQHTHKJscPq6NW4pCQBiMmHdUCvPN8ZOg2zJJTkC7WIezWv" crossorigin="anonymous">
<!--
Google fonts api stuff
-->
<link href='https://fonts.googleapis.com/css?family=helvetica' rel='stylesheet'>
<link href='https://fonts.googleapis.com/css?family=helvetica' rel='stylesheet'>
<title>Structural cerebellar connectivity in schizophrenia: support for the cognitive dysmetria theory</title>
<style>
@page {
size: 33in 46in;
margin: 0;
padding: 0;
}
body {
margin: 0;
font-size: 45px;
width: 33in;
height: 46in;
padding: 0;
text-align: justify;
font-family: helvetica;
}
.poster_wrap {
width: 33in;
height: 46in;
padding: 0cm;
}
.title_container {
width: 33in;
height: calc(46in * 0.15);
overflow: hidden;
background-color: #32006e;
border: 0 solid #0b4545;
}
.logo_left {
float: left;
width: 10%;
height: 100%;
background-color: #32006e;
display: flex;
align-items: center;
justify-content: center;
}
.logo_right {
float: right;
width: 10%;
height: 100%;
background-color: #32006e;
display: flex;
align-items: center;
justify-content: center;
}
.poster_title {
text-align: center;
position: relative;
float: left;
width: 80%;
height: 100%;
color: #FFFFFF;
top: 50%;
transform: translateY(-50%);
-webkit-transform: translateY(-50%);
}
#title {
font-family: helvetica;
}
/* unvisited link */
a:link {
color: #cc0000;
}
.mybreak {
break-before: column;
}
/* visited link */
a:visited {
color: #cc0000;
}
/* mouse over link */
a:hover {
color: #cc0000;
}
/* selected link */
a:active {
color: #cc0000;
}
.poster_body {
-webkit-column-count: 2; /* Chrome, Safari, Opera */
-moz-column-count: 2; /* Firefox */
column-count: 2;
-webkit-column-fill: auto;
-moz-column-fill: auto;
column-fill: auto;
-webkit-column-rule-width: 1mm;
-moz-column-rule-width: 1mm;
column-rule-width: 1mm;
-webkit-column-rule-style: dashed;
-moz-column-rule-style: dashed;
column-rule-style: dashed;
-webkit-column-rule-color: #32006e;
-moz-column-rule-color: #32006e;
column-rule-color: #32006e;
column-gap: 1em;
padding-left: 0.5em;
padding-right: 0.5em;
height: 100%;
color: #000000
background-color: #ffffff;
}
.poster_title h1 {
font-size: 75pt;
margin: 0;
border: 0;
font-weight: normal;
}
.poster_body_wrap{
width: calc(33in + 0 + 0);
height: calc(46in * 0.83);
padding-top: calc(46in * 0.005);
padding-bottom: calc(46in * 0.01);
background-color: #ffffff;
}
.poster_title h3 {
color: #ffffff;
font-size: 50pt;
margin: 0;
border: 0;
font-weight: normal;
}
.poster_title h3 > sup {
font-size: 35pt;
margin-left: 0.02em;
}
.poster_title h5 {
color: #FFFFFF;
font-size: ;
margin: 0;
border: 0;
font-weight: normal;
}
img {
margin-top: 2cm;
margin-bottom: 0;
}
.section {
padding: 0.2em;
}
.poster_body h1 {
text-align: center;
color: #FFFFFF;
font-size: 65pt;
border: 2mm solid #32006e;
background-color: #32006e;
border-radius: 4mm 0mm;
margin-top: 2mm;
margin-bottom: 2mm;
font-weight: normal;
}
.poster_body h2 {
color: #000000;
font-size: 40pt;
padding-left: 4mm;
font-weight: normal;
}
.span {
width: 200%;
}
/* center align leaflet map,
from https://stackoverflow.com/questions/52112119/center-leaflet-in-a-rmarkdown-document */
.html-widget {
margin: auto;
position: sticky;
margin-top: 2cm;
margin-bottom: 2cm;
}
.leaflet.html-widget.html-widget-static-bound.leaflet-container.leaflet-touch.leaflet-fade-anim.leaflet-grab.leaflet-touch-drag.leaflet-touch-zoom {
position: sticky;
width: 100%;
}
pre.sourceCode.r {
background-color: #dddddd40;
border-radius: 4mm;
padding: 4mm;
width: 75%;
/* align-items: center; */
margin: auto;
padding-left: 2cm;
}
code.sourceCode.r{
background-color: transparent;
font-size: 20pt;
border-radius: 2mm;
}
.caption {
font-size: 25pt;
}
.table caption {
font-size: 25pt;
padding-bottom: 3mm;
}
code {
font-size: 1em;
font-family: monospace;
background-color: #00808024;
color: #32006e;
padding: 1.2mm;
border-radius: 2mm;
}
.poster_title code {
font-size: 1em;
}
table {
font-size: 40px;
margin: auto;
border-top: 3px solid #666;
border-bottom: 3px solid #666;
}
table thead th {
border-bottom: 3px solid #ddd;
}
td {
padding: 8px;
}
th {
padding: 15px;
}
caption {
margin-bottom: 10px;
}
.poster_body p {
margin-right: 4mm;
margin-left: 4mm;
margin-top: 6mm;
margin-bottom: 10mm;
}
.poster_body ol {
margin-right: 4mm;
margin-left: 4mm;
}
#ul {
margin-right: 4mm;
margin-left: 4mm;
}
.references p {
font-size: 20pt;
}
.orcid img {
width: 1em;
}
</style>
</head>
<body>
<div class="poster_wrap">
<div class="title_container">
<!-- Left Logo -->
<div class="logo_left">
</div>
<!-- Poster Title -->
<div class= "poster_title">
<h1 id="title">Structural cerebellar connectivity in schizophrenia: support for the cognitive dysmetria theory</h1>
<h3 id="author">Teresa Gomez<sup>1</sup>, Sivan Jossinger<sup>2, 3</sup>, John Kruper<sup>1</sup>, Adam Richie-Halford<sup>4</sup>, Michal Ben-Shachar<sup>2</sup>, Jason Yeatman<sup>3</sup>, Ariel Rokem<sup>1</sup></h3><br>
<h5 id="affiliation"><sup>1</sup> Department of Psychology and eScience Institute, University of Washington<br> <sup>2</sup> Gonda Multidisciplinary Brain Research Center, Bar-Ilan University<br> <sup>3</sup> Functional MRI Center, Beilinson Hospital, Rabin Medical Center<br> <sup>4</sup> Graduate School of Education and Division of Developmental-Behavioral Pediatrics, Stanford University</h5>
</div>
<!-- Right Logo -->
<div class="logo_right">
</div>
</div>
<div class='poster_body_wrap'>
<div class='poster_body'>
<style>
.poster_body h1 {
font-family: "Helvetica";
}
body {
bottom-margin: 0px;
}
.poster_body h1 {
background-color: #b7a57a;
border: #85754d;
}
h5 br {
display: none;
}
.poster_title h3 {
font-family: "Helvetica";
}
.poster_title h5 {
font-family: "Helvetica";
width: 120%;
margin-left:-10%;
}
.title_container {
height: 150mm; }
img[src*='#logo'] {
width: 10%;
height: 10%
}
.mybreak {
break-before: column;
}
</style>
<p><img src="images/W-Logo_White.png" style="position: absolute; top: 50px; left: 50px;" height="200" />
<img src="images/Block_S_2_color_red.png" style="position: absolute; top: 150px; left: 2920px;" height="150" />
<img src="images/Bar_Ilan_seal.svg.png" style="position: absolute; top: -50px; left: 2900px;" height="150" /></p>
<p><img src="images/qr_poster.png" style="position: absolute; top: 3800px; left: 2900px;" height="260" /></p>
<p style="margin-top:-1cm">
<div id="background" class="section level1">
<h1>Background</h1>
</p>
<ul>
<li>Schizophrenia (SZ) is a neurodevelopmental psychiatric disorder that carries significant health burden.</li>
<li>The <em>cognitive dysmetria</em> theory of schizophrenia posits that the core cognitive deficits arise from dysfunctions of cortical-thalamic-cerebellar (CTC) circuits. <span class="citation">(<em>1</em>)</span></li>
<li>Previous research found increased functional connectivity in CTC in individuals at clinical high risk for psychosis. <span class="citation">(<em>2</em>)</span></li>
<li>This hyperconnectivity was more pronounced in individuals who converted to psychosis, correlated to the severity of symptoms, and was predictive of the time to conversion.</li>
<li>The cerebellum sends its output through the superior cerebellar peduncle (SCP), the contralateral red nucleus (RN), and VA/VL of the thalamus to various cerebral areas. The decussation (d) of the cerebero-thalamo-cortical pathway is indicated by the yellow circle (image taken from <span class="citation">(<em>3</em>)</span>).</li>
</ul>
<center>
<img src="images/palesi.png" style="width:60.0%;height:60.0%" />
</center>
<p><strong>QUESTION</strong>: Are the physical properties of the white matter tracts of the CTC different in individuals with SZ?</p>
</div>
<div id="methods" class="section level1">
<h1>Methods</h1>
<p style="margin-bottom:-1cm">
<strong>Data:</strong>
</p>
<ul>
<li>Diffusion MRI data (64 directions, b=1,000 <span class="math inline">\(s/mm^2\)</span>) from the UCLA Consortium for Neuropsychiatric Phenomics LA5c study (Open Neuro DS00030).</li>
<li>Participants: SZ (N=12F/37M, age: 36.2 <span class="math inline">\(\pm\)</span> 8.8 SD), ADHD (N=20F/20M age: 31.95 <span class="math inline">\(\pm\)</span> 10.3), bipolar disorder (BD; N=21F/28M, age: 35.3 <span class="math inline">\(\pm\)</span> 9.0), Healthy control (HC 58F/65M, age: 31.6 <span class="math inline">\(\pm\)</span> 8.8).</li>
</ul>
<p style="margin-bottom:-1cm">
<strong>Processing</strong>:
</p>
<ul>
<li>QSIPREP <span class="citation">(<em>4</em>)</span> and pyAFQ <span class="citation">(<em>5</em>)</span> for preprocessing, QC, and tractometry (FA/MD tract profiles).</li>
<li>Bilateral SCP were identified in each individual using anatomical criteria that capture the decussation <span class="citation">(<em>6</em>)</span>.</li>
<li>Group-blinded QC of SCP bundle was conducted by two expert observers (TG and AR).</li>
</ul>
<p style="margin-bottom:-1cm">
<strong>Analysis</strong>:
</p>
<ul>
<li>Data quality confounds were mitigated by matching each SZ/ADHD/BD to a HC with similar age, sex and data quality (neighbor correlations, NDC).</li>
<li>Generalized additive models (GAMs) for FA and MD in each SCP as <span class="citation">(<em>7</em>)</span>:
<p style="font-family:'Lucida Console', monospace">
FA/MD ~ group + s(nodeID, k, by=group) + <br> age + sex + QC + s(subjectID, bs=“re”)
</p>
with k chosen to minimize AIC and neighbor correlations <span class="citation">(<em>8</em>)</span> for QC.</li>
</ul>
</div>
<div id="acknowledgements" class="section level1">
<h1>Acknowledgements</h1>
<div style="font-size:36px">
<p>NIH grants: MH121867 (PI: Poldrack), MH121868 (PI: Rokem), EB027585 (PI: Garyfallidis)</p>
</div>
</div>
<div id="results" class="section level1 mybreak">
<h1>Results</h1>
<img src="images/SCP_right.png" style="width:24.0%;height:24.0%" />
<img src="images/SCP_back.png" style="width:24.0%;height:24.0%" />
<img src="images/SCP_left.png" style="width:24.0%;height:24.0%" />
<img src="images/SCP_top.png" style="width:24.0%;height:24.0%" />
<div style="font-size:32px; font-family:'Palatino'; text-align:center">
The left (dark blue) and right (light blue) SCP bundles visualized in an individual with SZ, with sagittal, coronal and axial anatomical views of the T1-weighted scan of this individual.
</div>
<center>
<img src="images/tract-profile_by-Group_dti-md.png" style="width:49.0%;height:49.0%" />
<img src="images/tract-profile_by-Group_dti-fa.png" style="width:49.0%;height:49.0%" />
</center>
<div style="font-size:32px; font-family:'Palatino'; text-align:center">
Tract profiles of MD (left) and FA (right) <span class="math inline">\(\pm\)</span> bootstrapped 95% confidence interval
</div>
<ul>
<li>Individuals with SZ had lower MD in left superior cerebellar peduncle (SCP) than HC (p<0.05).</li>
<li>This finding held after adding medication as a covariate (haloperidol equivalent dosage).</li>
<li>No significant differences were found in FA or in other group comparisons.</li>
</ul>
</div>
<div id="conclusions" class="section level1">
<h1>Conclusions</h1>
<ul>
<li>We found decreased MD in SZ in the left SCP, a component of the CTC.</li>
<li>In line with fMRI results that found increased functional connectivity in CTC in SZ <span class="citation">(<em>2</em>)</span>.</li>
<li>Provides additional support for the cognitive dysmetria theory of SZ.</li>
</ul>
</div>
<div id="software" class="section level1">
<h1>Software</h1>
<p><img src="images/qr_pyafq.png" style="position: absolute; top: 2850px; left: 1800px;" height="260" />
<img src="images/qr_tractable.png" style="position: absolute; top: 3300px; left: 1800px;" height="260" /></p>
<p style="margin-bottom:10cm">
<strong>pyAFQ</strong>: Automated Fiber <br> Quantification / tractometry
</p>
<p><img src="images/pyAFQ.png" style="position: absolute; top: 2700px; left: 2500px;" height="450" /></p>
<p style="margin-bottom:10cm">
<strong>Tractable</strong>: Statistical <br> analysis of tract profiles in R
</p>
<p><img src="images/cubic-spline-single.png" style="position: absolute; top: 3150px; left: 2500px;" height="460" /></p>
<p style="margin-top:-2cm">
</div>
<div id="references" class="section level1">
<h1>References</h1>
</p>
<div id="refs" class="references csl-bib-body">
<div id="ref-Andreasen1998-gg" class="csl-entry">
1. N. C. Andreasen <em>et al.</em>, <em>Schiz Bull</em>. <strong>24</strong>, 203–218 (1998).
</div>
<div id="ref-Cao2018" class="csl-entry">
2. H. Cao <em>et al.</em>, <em>Nature Communications</em>. <strong>9</strong>, 3836 (2018).
</div>
<div id="ref-Palesi2015-oi" class="csl-entry">
3. F. Palesi <em>et al.</em>, <em>Brain Struct. Funct.</em> <strong>220</strong>, 3369–3384 (2015).
</div>
<div id="ref-Cieslak2021-vj" class="csl-entry">
4. M. Cieslak <em>et al.</em>, <em>Nat. Methods</em>. <strong>18</strong>, 775–778 (2021).
</div>
<div id="ref-Kruper2021-az" class="csl-entry">
5. J. Kruper <em>et al.</em>, <em>Apert Neuro</em>. <strong>1</strong> (2021).
</div>
<div id="ref-Jossinger2023-gj" class="csl-entry">
6. S. Jossinger <em>et al.</em>, <em>Neurobiol. Lang.</em>, 1–40 (2023).
</div>
<div id="ref-Muncy2022GAMs" class="csl-entry">
7. N. M. Muncy <em>et al.</em>, <em>Neuroimage Clin</em>. <strong>33</strong>, 102937 (2022).
</div>
<div id="ref-Yeh2019NDC" class="csl-entry">
8. F.-C. Yeh <em>et al.</em>, <em>Neuroimage</em>. <strong>202</strong>, 116131 (2019).
</div>
</div>
</div>
</div>
</div>
</div>
<!-- dynamically load mathjax for compatibility with self-contained -->
<script>
(function () {
var script = document.createElement("script");
script.type = "text/javascript";
var src = "true";
if (src === "" || src === "true") src = "https://mathjax.rstudio.com/latest/MathJax.js?config=TeX-MML-AM_CHTML";
if (location.protocol !== "file:" && /^https?:/.test(src))
src = src.replace(/^https?:/, '');
script.src = src;
document.getElementsByTagName("head")[0].appendChild(script);
})();
</script>
</body>
</html>