diff --git a/images/SCP_back.png b/images/SCP_back.png new file mode 100644 index 0000000..07e3d08 Binary files /dev/null and b/images/SCP_back.png differ diff --git a/images/SCP_left.png b/images/SCP_left.png new file mode 100644 index 0000000..d1a7e49 Binary files /dev/null and b/images/SCP_left.png differ diff --git a/images/SCP_right.png b/images/SCP_right.png new file mode 100644 index 0000000..9ad2514 Binary files /dev/null and b/images/SCP_right.png differ diff --git a/images/SCP_top.png b/images/SCP_top.png new file mode 100644 index 0000000..1a315d1 Binary files /dev/null and b/images/SCP_top.png differ diff --git a/images/figure_mod.png b/images/figure_mod.png new file mode 100644 index 0000000..2ccb3af Binary files /dev/null and b/images/figure_mod.png differ diff --git a/poster.Rmd b/poster.Rmd index fd8e802..94604ed 100644 --- a/poster.Rmd +++ b/poster.Rmd @@ -2,26 +2,21 @@ poster_height: 46in poster_width: 33in -title: "Structural cerebellar connectivity in schizophrenia: Support for the cognitive dysmetria theory" +title: "Structural cerebellar connectivity in schizophrenia" author: - name: Teresa Gomez affil: 1 orcid: '0000-0001-7909-4430' - name: Sivan Jossinger affil: 2 - orcid: '0000-0000-0000-0000' - name: John Kruper affil: 1 - orcid: '0000-0000-0000-0000' - name: Adam Richie-Halford affil: 3 - orcid: '0000-0000-0000-0000' - name: Michal Ben-Shachar affil: 2 - orcid: '0000-0000-0000-0000' - name: Jason Yeatman affil: 3 - orcid: '0000-0000-0000-0000' - name: Ariel Rokem affil: 1 orcid: '0000-0003-0679-1985' @@ -41,7 +36,7 @@ titletext_fontfamily: "palatino" output: posterdown::posterdown_html: - self_contained: true + self_contained: no pandoc_args: ["--csl=science-without-titles.csl"] header-includes: @@ -59,8 +54,9 @@ knit: pagedown::chrome_print } body { -bottom-margin: 0px; + bottom-margin: 0px; } + .poster_body h1 { background-color: #b7a57a; border: #85754d; @@ -72,7 +68,6 @@ h5 br { .poster_title h3 { font-family: "Palatino", "URW Palladio L", "serif"; - } .poster_title h5 { @@ -82,7 +77,7 @@ h5 br { } .title_container { - height: 165mm; } + height: 180mm; } img[src*='#logo'] { width: 10%; @@ -102,36 +97,44 @@ knitr::opts_chunk$set(echo = FALSE) - Previous research found increased functional connectivity in the cerebello-thalamo-cortical circuits in individuals at clinical high risk for psychosis. [@Cao2018] - This hyperconnectivity was more pronounced in individuals who converted to psychosis, correlated to the severity of symptoms, and was predictive of the time to conversion. -![The cerebellum sends its output through the superior cerebellar peduncle (SCP), the contralateral red nucleus (RN), and VA/VL of the thalamus to various cerebral areas… The decussation (d) of the cerebero-thalamo-cortical pathway is indicated by the yellow circle. [@Palesi2015-oi]](images/palesi.jpg){#id .class width=100% height=100% } +
+ +![The cerebellum sends its output through the superior cerebellar peduncle (SCP), the contralateral red nucleus (RN), and VA/VL of the thalamus to various cerebral areas… The decussation (d) of the cerebero-thalamo-cortical pathway is indicated by the yellow circle. [@Palesi2015-oi]](images/palesi.jpg){width=60% height=60%} + +
**QUESTION**: Are the physical properties of the white matter tracts of the CTC different in individuals with SZ? +\ + # Methods -- **Data:** the UCLA Consortium for Neuropsychiatric Phenomics LA5c Study [@ds000030:1.0.0], which includes diffusion MRI (dMRI) data from 49 participants with SZ (mean age: 36.2 +/- 8.8 SD; 12 female), 40 participants with ADHD (mean age: 31.95 +/- 10.3 SD; 20 female), 49 participants with bipolar disorder (BP) (mean age: 35.3 +/- 9.0 SD, 21 female), and 123 controls (CTRL) (mean age: 31.6 +/- 8.8 SD; 58 female). +- **Data:** the UCLA Consortium for Neuropsychiatric Phenomics LA5c Study [@ds000030:1.0.0], which includes diffusion MRI (dMRI) data from 49 participants with SZ (mean age: 36.2 +/- 8.8 SD; 12 female), 40 participants with ADHD (mean age: 31.95 +/- 10.3 SD; 20 female), 49 participants with bipolar disorder (BD) (mean age: 35.3 +/- 9.0 SD, 21 female), and 123 controls (CTRL) (mean age: 31.6 +/- 8.8 SD; 58 female). - The data were processed using QSIPREP [@Cieslak2021-vj] and pyAFQ [@Kruper2021-az] [@Yeatman2012-ze] - The SCPs were identified in each individual using pyAFQ and anatomical criteria that capture the decussation of these bundles. [@Jossinger2023-gj] - This resulted in tract profiles of fractional anisotropy (FA) and mean diffusivity (MD) in each white matter pathway (100 nodes each). - We then fit generalized additive models (GAMs) for FA and MD in each bundle as a function of diagnosis (entered as a factor: SZ or CTRL), nodeID (modeled with an adaptive smooth, where degree of the smooth is determined as the k that minimizes the AIC), age, sex (entered as a factor) and data quality (quantified as the neighbor correlation from QSIPREP). [@Muncy2022GAMs] - +![](images/SCP_right.png){width=24% height=24%} +![](images/SCP_back.png){width=24% height=24%} +![](images/SCP_left.png){width=24% height=24%} +![](images/SCP_top.png){width=24% height=24%} +
The left (dark blue) and right (light blue) SCP bundles visualized in an individual with SZ, with sagittal, coronal and axial anatomical views of the T1-weighted scan of this individual.
-![a](images/sub-50010_SCP_right.png){#id .class width=25% height=25% } -![b](images/sub-50010_SCP_back.png){#id .class width=25% height=25% } -![c](images/sub-50010_SCP_top.png){#id .class width=25% height=25% } -![d](images/sub-50010_SCP_left.png){#id .class width=25% height=25% } -The left (dark blue) and right (light blue) SCP bundles visualized in an individual with SZ, with sagittal (a, d), coronal (b) and axial (c) anatomical views of the T1-weighted scan of this individual. +\ +\ +\ # Results -- MD differed significantly in the left superior cerebellar peduncle (SCP) between the SZ and CTRL groups (p<0.05), but not between the ADHD and CTRL groups or BP and CTRL groups. +![](images/figure_mod.png){width=100% height=100%} + +- MD differed significantly in the left superior cerebellar peduncle (SCP) between the SZ and CTRL groups (p<0.05), but not between the ADHD and CTRL groups or BD and CTRL groups. - Individuals with SZ had lower MD in this tract than the matched controls. - This finding held after adding medication as a covariate (haloperidol equivalent dosage). - No other significant differences were found. -![](images/figure.png){#id .class width=100% height=100% } +\ # Conclusions @@ -141,9 +144,12 @@ The left (dark blue) and right (light blue) SCP bundles visualized in an individ - These results appear in line with previous fMRI results that found increased functional connectivity in the CTC in individuals with SZ. [@Cao2018] - This provides additional support for the cognitive dysmetria theory of SZ. +\ # Acknowledgements NIMH grants: MH121867 (PI: Poldrack), MH121868 (PI: Rokem), EB027585 (PI: Garyfallidis) +\ + # References diff --git a/references.bib b/references.bib index a131e1b..e1d0136 100644 --- a/references.bib +++ b/references.bib @@ -203,7 +203,6 @@ @dataset{ds000030:1.0.0 Freimer, N and Congdon, E and Karlsgodt, K and Sabb, F", title = "UCLA Consortium for Neuropsychiatric Phenomics LA5c Study", year = 2020, - doi = "10.18112/openneuro.ds000030.v1.0.0", publisher = "OpenNeuro", } @ARTICLE{Cieslak2021-vj,