-
Notifications
You must be signed in to change notification settings - Fork 0
/
run206.lst
616 lines (440 loc) · 19.5 KB
/
run206.lst
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
490
491
492
493
494
495
496
497
498
499
500
501
502
503
504
505
506
507
508
509
510
511
512
513
514
515
516
517
518
519
520
521
522
523
524
525
526
527
528
529
530
531
532
533
534
535
536
537
538
539
540
541
542
543
544
545
546
547
548
549
550
551
552
553
554
555
556
557
558
559
560
561
562
563
564
565
566
567
568
569
570
571
572
573
574
575
576
577
578
579
580
581
582
583
584
585
586
587
588
589
590
591
592
593
594
595
596
597
598
599
600
601
602
603
604
605
606
607
608
609
610
611
612
613
614
615
616
2017-08-27
¿ÀÈÄ 01:04
;; 1. Based on:
;; 2. Description: Final PK model
;; x1. Author: user
;; 3. Label:
$PROBLEM Final PK model
$INPUT ID TIMEM=DROP TIME RAWDV=DROP DV AMT IIMIN=DROP II ADDL
CMT DOSE=DROP OXY=DROP SEX PERIOD=DROP WATER=DROP MDV
AGE=DROP HT=DROP WT SCR=DROP AST=DROP ALT=DROP
; Units
;; DV = g/L
;; AMT = g
$DATA PKdata_ver5.csv IGNORE=#
$SUBROUTINE ADVAN6 TOL=6
$MODEL NCOMP=2 COMP=(DEPOT) COMP=(CENTRAL)
$PK
;;; VMSEX-DEFINITION START
IF(SEX.EQ.1) VMSEX = 1 ; Most common
IF(SEX.EQ.2) VMSEX = ( 1 + THETA(8))
;;; VMSEX-DEFINITION END
;;; VM-RELATION START
VMCOV=VMSEX
;;; VM-RELATION END
;;; VCWT-DEFINITION START
VCWT = ( 1 + THETA(7)*(WT - 69))
;;; VCWT-DEFINITION END
;;; VC-RELATION START
VCCOV=VCWT
;;; VC-RELATION END
; Population parameter
TVKA = THETA(1)
TVVC = THETA(2)
TVVC = VCCOV*TVVC
TVVM = THETA(3)
TVVM = VMCOV*TVVM
TVKM = THETA(4)
; Individual parameter
KA = TVKA; * EXP(ETA(1))
VC = TVVC * EXP(ETA(1))
VM = TVVM * EXP(ETA(2))
KM = TVKM; * EXP(ETA(2))
S2 = VC
;KEL = CL/VC
$DES
CONC = A(2)/VC
DADT(1) = -KA*A(1)
DADT(2) = KA*A(1) - VM*CONC/(KM+CONC)
$ERROR
IPRED = F
W = SQRT(THETA(5)**2*IPRED**2 + THETA(6)**2)
Y = IPRED + W*EPS(1)
IRES = DV-IPRED
IWRES = IRES/W
$THETA (0,8.09658) ; 1.KA
(0,73.6782) ; 2.VC
(0,9.64917) ; 3.Vmax
(0,0.0408837) ; 4. Km
(0,0.179277) ; Prop.RE (sd)
(0,0.001) FIX ; Add.RE (sd)
$THETA (-0.111,0.016739,0.045) ; VCWT1
$THETA (-1,-0.235138,5) ; VMSEX1
$OMEGA 0.0498046 ; VC
0.0116147 ; VM
;0.47 2.71 ; KM
$SIGMA 1 FIX ; Proportional error PK
$ESTIMATION METHOD=1 INTER MAXEVAL=5000 NOABORT NSIG=3 SIGL=6 PRINT=5
; Xpose
$TABLE ID TIME DV MDV IPRED IWRES CWRES ONEHEADER NOPRINT
FILE=sdtab206
$TABLE ID VC KA VM KM ETA(1) ETA(2) ONEHEADER NOPRINT
FILE=patab206
;$TABLE ID SEX ONEHEADER NOPRINT FILE=catab206
;$TABLE ID AGE HT WT SCR AST ALT ONEHEADER NOPRINT FILE=cotab206
$COVARIANCE
NM-TRAN MESSAGES
WARNINGS AND ERRORS (IF ANY) FOR PROBLEM 1
(WARNING 2) NM-TRAN INFERS THAT THE DATA ARE POPULATION.
License Registered to: Chungnam National University
Expiration Date: 14 JAN 2018
Current Date: 27 AUG 2017
Days until program expires : 142
1NONLINEAR MIXED EFFECTS MODEL PROGRAM (NONMEM) VERSION 7.3.0
ORIGINALLY DEVELOPED BY STUART BEAL, LEWIS SHEINER, AND ALISON BOECKMANN
CURRENT DEVELOPERS ARE ROBERT BAUER, ICON DEVELOPMENT SOLUTIONS,
AND ALISON BOECKMANN. IMPLEMENTATION, EFFICIENCY, AND STANDARDIZATION
PERFORMED BY NOUS INFOSYSTEMS.
PROBLEM NO.: 1
Final PK model
0DATA CHECKOUT RUN: NO
DATA SET LOCATED ON UNIT NO.: 2
THIS UNIT TO BE REWOUND: NO
NO. OF DATA RECS IN DATA SET: 1141
NO. OF DATA ITEMS IN DATA SET: 11
ID DATA ITEM IS DATA ITEM NO.: 1
DEP VARIABLE IS DATA ITEM NO.: 3
MDV DATA ITEM IS DATA ITEM NO.: 9
0INDICES PASSED TO SUBROUTINE PRED:
11 2 4 0 0 5 7 0 0 0 6
0LABELS FOR DATA ITEMS:
ID TIME DV AMT II ADDL CMT SEX MDV WT EVID
0(NONBLANK) LABELS FOR PRED-DEFINED ITEMS:
KA VC VM KM IPRED IWRES
0FORMAT FOR DATA:
(E3.0,E12.0,2E6.0,E12.0,4E2.0,E5.0,1F2.0)
TOT. NO. OF OBS RECS: 823
TOT. NO. OF INDIVIDUALS: 53
0LENGTH OF THETA: 8
0DEFAULT THETA BOUNDARY TEST OMITTED: NO
0OMEGA HAS SIMPLE DIAGONAL FORM WITH DIMENSION: 2
0DEFAULT OMEGA BOUNDARY TEST OMITTED: NO
0SIGMA HAS SIMPLE DIAGONAL FORM WITH DIMENSION: 1
0DEFAULT SIGMA BOUNDARY TEST OMITTED: NO
0INITIAL ESTIMATE OF THETA:
LOWER BOUND INITIAL EST UPPER BOUND
0.0000E+00 0.8097E+01 0.1000E+07
0.0000E+00 0.7368E+02 0.1000E+07
0.0000E+00 0.9649E+01 0.1000E+07
0.0000E+00 0.4088E-01 0.1000E+07
0.0000E+00 0.1793E+00 0.1000E+07
0.1000E-02 0.1000E-02 0.1000E-02
-0.1110E+00 0.1674E-01 0.4500E-01
-0.1000E+01 -0.2351E+00 0.5000E+01
0INITIAL ESTIMATE OF OMEGA:
0.4980E-01
0.0000E+00 0.1161E-01
0INITIAL ESTIMATE OF SIGMA:
0.1000E+01
0SIGMA CONSTRAINED TO BE THIS INITIAL ESTIMATE
0COVARIANCE STEP OMITTED: NO
EIGENVLS. PRINTED: NO
SPECIAL COMPUTATION: NO
COMPRESSED FORMAT: NO
SIGDIGITS ETAHAT (SIGLO): -1
SIGDIGITS GRADIENTS (SIGL): -1
RELATIVE TOLERANCE (TOL): -1
ABSOLUTE TOLERANCE-ADVAN 9,13 ONLY (ATOL): -1
EXCLUDE COV FOR FOCE (NOFCOV): NO
RESUME COV ANALYSIS (RESUME): NO
0TABLES STEP OMITTED: NO
NO. OF TABLES: 2
SEED NUMBER (SEED): 11456
RANMETHOD:
MC SAMPLES (ESEED): 300
WRES SQUARE ROOT TYPE: EIGENVALUE
0-- TABLE 1 --
PRINTED: NO
HEADERS: ONE
FILE TO BE FORWARDED: NO
FORMAT: S1PE11.4
LFORMAT:
RFORMAT:
0USER-CHOSEN ITEMS:
ID TIME DV MDV IPRED IWRES CWRES
0-- TABLE 2 --
PRINTED: NO
HEADERS: ONE
FILE TO BE FORWARDED: NO
FORMAT: S1PE11.4
LFORMAT:
RFORMAT:
0USER-CHOSEN ITEMS:
ID VC KA VM KM ETA1 ETA2
1DOUBLE PRECISION PREDPP VERSION 7.3.0
GENERAL NONLINEAR KINETICS MODEL (ADVAN6)
0MODEL SUBROUTINE USER-SUPPLIED - ID NO. 9999
0MAXIMUM NO. OF BASIC PK PARAMETERS: 4
0COMPARTMENT ATTRIBUTES
COMPT. NO. FUNCTION INITIAL ON/OFF DOSE DEFAULT DEFAULT
STATUS ALLOWED ALLOWED FOR DOSE FOR OBS.
1 DEPOT ON YES YES YES NO
2 CENTRAL ON YES YES NO YES
3 OUTPUT OFF YES NO NO NO
0NRD VALUE FROM SUBROUTINE TOL: 6
1
ADDITIONAL PK PARAMETERS - ASSIGNMENT OF ROWS IN GG
COMPT. NO. INDICES
SCALE BIOAVAIL. ZERO-ORDER ZERO-ORDER ABSORB
FRACTION RATE DURATION LAG
1 * * * * *
2 5 * * * *
3 * - - - -
- PARAMETER IS NOT ALLOWED FOR THIS MODEL
* PARAMETER IS NOT SUPPLIED BY PK SUBROUTINE;
WILL DEFAULT TO ONE IF APPLICABLE
0DATA ITEM INDICES USED BY PRED ARE:
EVENT ID DATA ITEM IS DATA ITEM NO.: 11
TIME DATA ITEM IS DATA ITEM NO.: 2
DOSE AMOUNT DATA ITEM IS DATA ITEM NO.: 4
INTERVAL DATA ITEM IS DATA ITEM NO.: 5
ADDL. DOSES DATA ITEM IS DATA ITEM NO.: 6
COMPT. NO. DATA ITEM IS DATA ITEM NO.: 7
0PK SUBROUTINE CALLED WITH EVERY EVENT RECORD.
PK SUBROUTINE NOT CALLED AT NONEVENT (ADDITIONAL OR LAGGED) DOSE TIMES.
0ERROR SUBROUTINE CALLED WITH EVERY EVENT RECORD.
0DES SUBROUTINE USES COMPACT STORAGE MODE.
1
#TBLN: 1
#METH: First Order Conditional Estimation with Interaction
ESTIMATION STEP OMITTED: NO
ANALYSIS TYPE: POPULATION
CONDITIONAL ESTIMATES USED: YES
CENTERED ETA: NO
EPS-ETA INTERACTION: YES
LAPLACIAN OBJ. FUNC.: NO
NO. OF FUNCT. EVALS. ALLOWED: 5000
NO. OF SIG. FIGURES REQUIRED: 3
INTERMEDIATE PRINTOUT: YES
ESTIMATE OUTPUT TO MSF: NO
ABORT WITH PRED EXIT CODE 1: NO
IND. OBJ. FUNC. VALUES SORTED: NO
NUMERICAL DERIVATIVE
FILE REQUEST (NUMDER): NONE
MAP (ETAHAT) ESTIMATION METHOD (OPTMAP): 0
ETA HESSIAN EVALUATION METHOD (ETADER): 0
INITIAL ETA FOR MAP ESTIMATION (MCETA): 0
SIGDIGITS FOR MAP ESTIMATION (SIGLO): 6
GRADIENT SIGDIGITS OF
FIXED EFFECTS PARAMETERS (SIGL): 6
EXCLUDE TITLE (NOTITLE): NO
EXCLUDE COLUMN LABELS (NOLABEL): NO
NOPRIOR SETTING (NOPRIOR): OFF
NOCOV SETTING (NOCOV): OFF
DERCONT SETTING (DERCONT): OFF
ABSOLUTE TOLERANCE-ADVAN 9,13 ONLY(ATOL):-100
FINAL ETA RE-EVALUATION (FNLETA): ON
EXCLUDE NON-INFLUENTIAL (NON-INFL.) ETAS
IN SHRINKAGE (ETASTYPE): NO
NON-INFL. ETA CORRECTION (NONINFETA): OFF
FORMAT FOR ADDITIONAL FILES (FORMAT): S1PE12.5
PARAMETER ORDER FOR OUTPUTS (ORDER): TSOL
ADDITIONAL CONVERGENCE TEST (CTYPE=4)?: NO
EM OR BAYESIAN METHOD USED: NONE
THE FOLLOWING LABELS ARE EQUIVALENT
PRED=PREDI
RES=RESI
WRES=WRESI
IWRS=IWRESI
IPRD=IPREDI
IRS=IRESI
MONITORING OF SEARCH:
0ITERATION NO.: 0 OBJECTIVE VALUE: -2477.21427061810 NO. OF FUNC. EVALS.: 9
CUMULATIVE NO. OF FUNC. EVALS.: 9
NPARAMETR: 8.0966E+00 7.3678E+01 9.6492E+00 4.0884E-02 1.7928E-01 1.6739E-02 -2.3514E-01 4.9805E-02 1.1615E-02
PARAMETER: 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01
GRADIENT: 1.3842E-02 2.4111E+00 5.3762E+00 1.5983E-02 1.7119E-01 2.3799E-01 1.1076E+00 -7.5399E-04 -2.9891E-03
0ITERATION NO.: 4 OBJECTIVE VALUE: -2477.21427101116 NO. OF FUNC. EVALS.: 14
CUMULATIVE NO. OF FUNC. EVALS.: 96
NPARAMETR: 8.0965E+00 7.3678E+01 9.6491E+00 4.0889E-02 1.7928E-01 1.6739E-02 -2.3514E-01 4.9805E-02 1.1615E-02
PARAMETER: 9.9994E-02 1.0000E-01 9.9996E-02 1.0014E-01 9.9999E-02 9.9996E-02 1.0000E-01 1.0000E-01 1.0002E-01
GRADIENT: 1.3952E-04 -4.5411E-03 -2.9977E-02 1.0904E-03 3.6343E-03 4.5275E-04 -1.2416E-02 -1.9827E-03 -1.3826E-03
#TERM:
0MINIMIZATION SUCCESSFUL
HOWEVER, PROBLEMS OCCURRED WITH THE MINIMIZATION.
REGARD THE RESULTS OF THE ESTIMATION STEP CAREFULLY, AND ACCEPT THEM ONLY
AFTER CHECKING THAT THE COVARIANCE STEP PRODUCES REASONABLE OUTPUT.
NO. OF FUNCTION EVALUATIONS USED: 96
NO. OF SIG. DIGITS IN FINAL EST.: 3.1
ETABAR IS THE ARITHMETIC MEAN OF THE ETA-ESTIMATES,
AND THE P-VALUE IS GIVEN FOR THE NULL HYPOTHESIS THAT THE TRUE MEAN IS 0.
ETABAR: -6.1782E-03 6.4498E-03
SE: 2.9476E-02 1.3257E-02
N: 53 53
P VAL.: 8.3398E-01 6.2659E-01
ETAshrink(%): 2.9236E+00 9.5943E+00
EBVshrink(%): 3.8670E+00 1.1215E+01
EPSshrink(%): 5.3806E+00
#TERE:
Elapsed estimation time in seconds: 10.95
Elapsed covariance time in seconds: 24.39
1
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ********************
#OBJT:************** MINIMUM VALUE OF OBJECTIVE FUNCTION ********************
******************** ********************
************************************************************************************************************************
#OBJV:******************************************** -2477.214 **************************************************
1
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ********************
******************** FINAL PARAMETER ESTIMATE ********************
******************** ********************
************************************************************************************************************************
THETA - VECTOR OF FIXED EFFECTS PARAMETERS *********
TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 TH 8
8.10E+00 7.37E+01 9.65E+00 4.09E-02 1.79E-01 1.00E-03 1.67E-02 -2.35E-01
OMEGA - COV MATRIX FOR RANDOM EFFECTS - ETAS ********
ETA1 ETA2
ETA1
+ 4.98E-02
ETA2
+ 0.00E+00 1.16E-02
SIGMA - COV MATRIX FOR RANDOM EFFECTS - EPSILONS ****
EPS1
EPS1
+ 1.00E+00
1
OMEGA - CORR MATRIX FOR RANDOM EFFECTS - ETAS *******
ETA1 ETA2
ETA1
+ 2.23E-01
ETA2
+ 0.00E+00 1.08E-01
SIGMA - CORR MATRIX FOR RANDOM EFFECTS - EPSILONS ***
EPS1
EPS1
+ 1.00E+00
1
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ********************
******************** STANDARD ERROR OF ESTIMATE ********************
******************** ********************
************************************************************************************************************************
THETA - VECTOR OF FIXED EFFECTS PARAMETERS *********
TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 TH 8
1.87E+00 2.65E+00 7.03E-01 4.27E-02 7.20E-03 ......... 2.03E-03 2.87E-02
OMEGA - COV MATRIX FOR RANDOM EFFECTS - ETAS ********
ETA1 ETA2
ETA1
+ 1.04E-02
ETA2
+ ......... 5.39E-03
SIGMA - COV MATRIX FOR RANDOM EFFECTS - EPSILONS ****
EPS1
EPS1
+ .........
1
OMEGA - CORR MATRIX FOR RANDOM EFFECTS - ETAS *******
ETA1 ETA2
ETA1
+ 2.33E-02
ETA2
+ ......... 2.50E-02
SIGMA - CORR MATRIX FOR RANDOM EFFECTS - EPSILONS ***
EPS1
EPS1
+ .........
1
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ********************
******************** COVARIANCE MATRIX OF ESTIMATE ********************
******************** ********************
************************************************************************************************************************
TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 TH 8 OM11 OM12 OM22 SG11
TH 1
+ 3.50E+00
TH 2
+ -5.04E-01 7.04E+00
TH 3
+ -4.79E-01 -9.73E-02 4.95E-01
TH 4
+ -3.16E-02 -5.26E-06 2.89E-02 1.83E-03
TH 5
+ -3.58E-04 6.49E-03 1.88E-04 3.38E-05 5.18E-05
TH 6
+ ......... ......... ......... ......... ......... .........
TH 7
+ -1.74E-04 3.71E-03 -7.43E-05 4.15E-07 3.01E-06 ......... 4.12E-06
TH 8
+ 8.09E-04 7.01E-03 -1.16E-02 -5.58E-04 1.53E-05 ......... -4.27E-06 8.25E-04
OM11
+ -2.10E-03 1.10E-02 3.19E-03 2.12E-04 1.97E-05 ......... 5.50E-06 -5.85E-05 1.08E-04
OM12
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
OM22
+ 1.26E-03 3.13E-03 1.43E-04 -2.84E-05 -4.91E-06 ......... 1.52E-06 -3.16E-05 1.60E-06 ......... 2.90E-05
SG11
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
1
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ********************
******************** CORRELATION MATRIX OF ESTIMATE ********************
******************** ********************
************************************************************************************************************************
TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 TH 8 OM11 OM12 OM22 SG11
TH 1
+ 1.87E+00
TH 2
+ -1.02E-01 2.65E+00
TH 3
+ -3.64E-01 -5.21E-02 7.03E-01
TH 4
+ -3.96E-01 -4.63E-05 9.61E-01 4.27E-02
TH 5
+ -2.66E-02 3.39E-01 3.72E-02 1.10E-01 7.20E-03
TH 6
+ ......... ......... ......... ......... ......... .........
TH 7
+ -4.58E-02 6.89E-01 -5.20E-02 4.78E-03 2.06E-01 ......... 2.03E-03
TH 8
+ 1.51E-02 9.19E-02 -5.76E-01 -4.55E-01 7.42E-02 ......... -7.32E-02 2.87E-02
OM11
+ -1.08E-01 4.00E-01 4.36E-01 4.76E-01 2.63E-01 ......... 2.61E-01 -1.96E-01 1.04E-02
OM12
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
OM22
+ 1.25E-01 2.19E-01 3.78E-02 -1.23E-01 -1.27E-01 ......... 1.39E-01 -2.04E-01 2.86E-02 ......... 5.39E-03
SG11
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
1
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ********************
******************** INVERSE COVARIANCE MATRIX OF ESTIMATE ********************
******************** ********************
************************************************************************************************************************
TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 TH 8 OM11 OM12 OM22 SG11
TH 1
+ 3.76E-01
TH 2
+ 5.81E-02 3.78E-01
TH 3
+ 6.54E-01 3.15E-01 6.71E+01
TH 4
+ -6.24E-01 -2.70E+00 -1.00E+03 1.61E+04
TH 5
+ -6.43E+00 -2.33E+01 9.71E+01 -1.83E+03 2.37E+04
TH 6
+ ......... ......... ......... ......... ......... .........
TH 7
+ 1.07E+01 -2.71E+02 1.66E+03 -2.31E+04 5.98E+03 ......... 5.29E+05
TH 8
+ 6.47E+00 -5.00E+00 2.27E+02 -2.70E+03 -3.34E+01 ......... 1.23E+04 2.65E+03
OM11
+ -1.23E+01 -2.55E+01 2.84E-01 -1.99E+03 -1.75E+03 ......... 3.05E+03 5.22E+01 1.57E+04
OM12
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
OM22
+ -2.03E+01 -4.13E+01 -1.20E+03 1.91E+04 4.28E+03 ......... -1.55E+04 -1.27E+03 8.35E+01 ......... 6.45E+04
SG11
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
#CPUT: Total CPU Time in Seconds, 36.063
Stop Time:
2017-08-27
¿ÀÈÄ 01:05