update: v0.9.2-20210830

Author: shanmdphd

02.Rmd

@@ -33,7 +33,7 @@ knitr::include_graphics('media-02/image1.png')
 생리학적인 가정이 없는 상황에서 의약품 투여 후 경과 시간은 농도 변화를 기술할 수 있는 유일한 독립변인이므로, 이러한 방법은 꽤나 타당한 것이다. 
 그림 \@ref(fig:pk-table)은 이러한 방식으로 나타낸 시간대 별 약물농도표이다.
 
-```{r pk-table, fig.cap = "(ref:pk-table)", out.width="130%"}
+```{r pk-table, fig.cap = "(ref:pk-table)", out.width="100%"}
 knitr::include_graphics('media-02/image2.png')
 ```
 

04.Rmd

@@ -283,7 +283,7 @@ k~e~) 수 밖에 없다. 만약 말초구획이 존재하지 않고 중심구획
 k~e~가 관찰된다.
 \index{만니톨, mannitol}
 
-```{r fig4-6, fig.cap = "(ref:fig4-6)"}
+```{r fig4-6, fig.cap = "(ref:fig4-6)", out.width="80%"}
 knitr::include_graphics('media-04/image6.png')
 ```
 

Output-ncar/pdfNCA-Theoph-00.png

@@ -2,7 +2,7 @@
                        Package version 0.4.4 (2021-07-16 KST)
                           R version 4.1.1 (2021-08-10)
 
-Date and Time: 2021-08-29 16:24:59 Asia/Seoul
+Date and Time: 2021-08-30 01:03:16 Asia/Seoul
 
 Calculation Setting
 -------------------

Output-ncar/pdfNCA-Theoph-01.png

@@ -137,14 +137,21 @@
 %]{crop}
 
 \usepackage{graphicx}
+%\usepackage{polyglossia}
+%\usepackage{ctex}
+\usepackage{fontspec}
+\usepackage{xetexko}
+\setmainfont{Noto Serif CJK KR}
+%\setmainhangulfont{Noto Serif CJK KR} 
+%\setmainhanjafont{Noto Serif CJK KR}[Language=Chinese Simplified]
 
 %sungpil defined above
 
 \usepackage{booktabs}
 \usepackage{longtable}
 \usepackage[bf,singlelinecheck=off]{caption}
 
-%\usepackage[utf8]{inputenc}
+\usepackage[utf8]{inputenc}
 
 %\usepackage{xeCJK}
 %\setCJKmainfont[$for(CJKoptions)$$CJKoptions$$sep$,$endfor$]{$CJKmainfont$}
@@ -298,7 +305,7 @@
 
 (I-기본원리과 자료해석)}
 \author{가톨릭대학교 계량약리학연구소(PIPET) 펴냄 (대표저자 임동석) - v0.9.2 (2021-08-29)}
-\date{2021-08-29}
+\date{2021-08-30}
 
 \usepackage{amsthm}
 \newtheorem{theorem}{Theorem}[chapter]
@@ -320,6 +327,8 @@
 \begin{document}
 \maketitle
 
+%sungpil added above
+
 %\cleardoublepage\newpage\thispagestyle{empty}\null
 %\cleardoublepage\newpage\thispagestyle{empty}\null
 %\cleardoublepage\newpage
@@ -1179,7 +1188,7 @@ \section{\texorpdfstring{경구투여의 약동학\index{약동학}}{경구투
 
 \begin{figure}
 
-{\centering \includegraphics[width=1\linewidth]{media-01/image13} 
+{\centering \includegraphics[width=0.8\linewidth]{media-01/image13} 
 
 }
 
@@ -1316,7 +1325,7 @@ \section{비구획분석의 기본 개념과 관심사}\label{uxbe44uxad6cuxd68d
 
 \begin{figure}
 
-{\centering \includegraphics[width=1.3\linewidth]{media-02/image2} 
+{\centering \includegraphics[width=1\linewidth]{media-02/image2} 
 
 }
 
@@ -2226,7 +2235,7 @@ \subsection{txtNCA()}\label{txtnca}}
                        \ExtensionTok{Package}\NormalTok{ version 0.4.4 }\ErrorTok{(}\ExtensionTok{2021{-}07{-}16}\NormalTok{ KST}\KeywordTok{)}
                           \ExtensionTok{R}\NormalTok{ version 4.1.1 }\ErrorTok{(}\ExtensionTok{2021{-}08{-}10}\KeywordTok{)}
 
-\ExtensionTok{Date}\NormalTok{ and Time: 2021{-}08{-}29 16:52:48 Asia/Seoul}
+\ExtensionTok{Date}\NormalTok{ and Time: 2021{-}08{-}30 01:03:16 Asia/Seoul}
 
 \ExtensionTok{Calculation}\NormalTok{ Setting}
 \ExtensionTok{{-}{-}{-}{-}{-}{-}{-}{-}{-}{-}{-}{-}{-}{-}{-}{-}{-}{-}{-}}
@@ -3063,6 +3072,7 @@ \section{구획모델로 얻은 PK 파라미터와 NCA로 얻은 PK 파라미터
 
 \caption{\label{tab:pk-param-comparison}NCA와 구획모델 분석으로 얻어지는 PK 파라미터 비교}
 \centering
+\fontsize{9}{11}\selectfont
 \begin{tabular}[t]{>{\raggedright\arraybackslash}p{2.0cm}>{\raggedright\arraybackslash}p{4.0cm}>{\raggedright\arraybackslash}p{4.0cm}>{\raggedright\arraybackslash}p{3.0cm}}
 \toprule
 파라미터의 속성 & NCA 로 구한 파라미터 & 구획분석으로 구한 파라미터 & 비고\\
@@ -3135,7 +3145,7 @@ \subsection{\texorpdfstring{β와 k\textsubscript{e}(k\textsubscript{10})의 차
 
 \begin{figure}
 
-{\centering \includegraphics[width=1\linewidth]{media-04/image6} 
+{\centering \includegraphics[width=0.8\linewidth]{media-04/image6} 
 
 }
 
@@ -3402,7 +3412,7 @@ \subsection{Compartmental analysis without Tlag}\label{compartmental-analysis-wi
 ##            ka      V         k AddErrVar AddErrSD
 ## PE   0.013202 21.018  0.013202   0.08701  0.29498
 ## SE   0.005442  8.623  0.005442   0.03413  0.05785
-## RSE 41.220612 41.029 41.220652  39.22314 19.61157
+## RSE 41.220676 41.029 41.220716  39.22314 19.61157
 \end{verbatim}
 
 \hypertarget{compartmental-analysis-with-tlag}{%
@@ -3719,13 +3729,13 @@ \subsection{Compartmental analysis without Tlag}\label{compartmental-analysis-wi
 
 \begin{verbatim}
 ##      Vc/F     Ka      k21  alpha     beta AddErrVar
-## PE  43.63  2.350   0.6979  2.346   0.3973     537.2
-## SE  40.61  2.222   0.9644  2.222   0.4938     203.0
-## RSE 93.07 94.574 138.1807 94.704 124.2789      37.8
+## PE  43.59  2.347   0.6955  2.347   0.3960    537.13
+## SE  40.96  2.240   0.9594  2.241   0.4919    202.99
+## RSE 93.98 95.439 137.9449 95.482 124.2005     37.79
 ##     AddErrSD
-## PE     23.18
-## SE      4.38
-## RSE    18.90
+## PE    23.176
+## SE     4.379
+## RSE   18.896
 \end{verbatim}
 
 \hypertarget{compartmental-analysis-with-tlag-1}{%
@@ -3762,14 +3772,14 @@ \subsection{Compartmental analysis with Tlag}\label{compartmental-analysis-with-
 \end{Shaded}
 
 \begin{verbatim}
-##       Vc/F     Ka       k21   alpha      beta     Tlag
-## PE  88.530 19.778 7.970e-03 0.73179 2.022e-03 0.121649
-## SE   2.319  3.774 1.245e-01 0.04592 1.131e-01 0.008134
-## RSE  2.619 19.085 1.562e+03 6.27477 5.592e+03 6.686128
+##       Vc/F     Ka       k21   alpha      beta    Tlag
+## PE  88.528 19.767 7.902e-03 0.73176 1.976e-03 0.12163
+## SE   2.315  3.763 1.243e-01 0.04575 1.129e-01 0.00812
+## RSE  2.615 19.036 1.573e+03 6.25139 5.713e+03 6.67610
 ##     AddErrVar AddErrSD
-## PE     17.890   4.2296
-## SE      6.848   0.8096
-## RSE    38.281  19.1403
+## PE     17.894   4.2301
+## SE      6.851   0.8098
+## RSE    38.288  19.1441
 \end{verbatim}
 
 \hypertarget{uxbaa8uxb378uxb9c1-uxacb0uxacfc-2}{%
@@ -4052,7 +4062,7 @@ \chapter{Theoph의 nlr의 전체 실행 결과}\label{Theoph_nlr}}
 ##  [9]  6.353e-05  1.018e-01  2.654e-01
 ## 
 ## $`Elapsed Time`
-## Time difference of 0.083 secs
+## Time difference of 0.02456 secs
 ## 
 ## [1] "## ID = 2 ##"
 ## $Est
@@ -4117,7 +4127,7 @@ \chapter{Theoph의 nlr의 전체 실행 결과}\label{Theoph_nlr}}
 ## [11]  0.008457
 ## 
 ## $`Elapsed Time`
-## Time difference of 0.017 secs
+## Time difference of 0.005103 secs
 ## 
 ## [1] "## ID = 3 ##"
 ## $Est
@@ -4182,7 +4192,7 @@ \chapter{Theoph의 nlr의 전체 실행 결과}\label{Theoph_nlr}}
 ## [11] -0.29760
 ## 
 ## $`Elapsed Time`
-## Time difference of 0.029 secs
+## Time difference of 0.006164 secs
 ## 
 ## [1] "## ID = 4 ##"
 ## $Est
@@ -4246,7 +4256,7 @@ \chapter{Theoph의 nlr의 전체 실행 결과}\label{Theoph_nlr}}
 ##  [7] -0.2575 -0.2352  0.2780  0.2901 -0.1376
 ## 
 ## $`Elapsed Time`
-## Time difference of 0.019 secs
+## Time difference of 0.005083 secs
 ## 
 ## [1] "## ID = 5 ##"
 ## $Est
@@ -4311,7 +4321,7 @@ \chapter{Theoph의 nlr의 전체 실행 결과}\label{Theoph_nlr}}
 ## [11]  0.102075
 ## 
 ## $`Elapsed Time`
-## Time difference of 0.016 secs
+## Time difference of 0.005303 secs
 ## 
 ## [1] "## ID = 6 ##"
 ## $Est
@@ -4375,7 +4385,7 @@ \chapter{Theoph의 nlr의 전체 실행 결과}\label{Theoph_nlr}}
 ##  [7] -0.2104 -0.2191  0.0595  0.2268  0.1271
 ## 
 ## $`Elapsed Time`
-## Time difference of 0.013 secs
+## Time difference of 0.006101 secs
 ## 
 ## [1] "## ID = 7 ##"
 ## $Est
@@ -4439,7 +4449,7 @@ \chapter{Theoph의 nlr의 전체 실행 결과}\label{Theoph_nlr}}
 ##  [7]  0.1209 -0.3054 -0.1850  0.1653  0.1796
 ## 
 ## $`Elapsed Time`
-## Time difference of 0.015 secs
+## Time difference of 0.009145 secs
 ## 
 ## [1] "## ID = 8 ##"
 ## $Est
@@ -4503,7 +4513,7 @@ \chapter{Theoph의 nlr의 전체 실행 결과}\label{Theoph_nlr}}
 ##  [7] -0.1496 -0.2478  0.3974 -0.1579  0.2044
 ## 
 ## $`Elapsed Time`
-## Time difference of 0.013 secs
+## Time difference of 0.005211 secs
 ## 
 ## [1] "## ID = 9 ##"
 ## $Est
@@ -4567,7 +4577,7 @@ \chapter{Theoph의 nlr의 전체 실행 결과}\label{Theoph_nlr}}
 ##  [7]  0.2990 -0.2183  0.2389  0.1227  0.1205
 ## 
 ## $`Elapsed Time`
-## Time difference of 0.03 secs
+## Time difference of 0.007214 secs
 ## 
 ## [1] "## ID = 10 ##"
 ## $Est
@@ -4632,7 +4642,7 @@ \chapter{Theoph의 nlr의 전체 실행 결과}\label{Theoph_nlr}}
 ## [11] -0.01104
 ## 
 ## $`Elapsed Time`
-## Time difference of 0.025 secs
+## Time difference of 0.007373 secs
 ## 
 ## [1] "## ID = 11 ##"
 ## $Est
@@ -4697,7 +4707,7 @@ \chapter{Theoph의 nlr의 전체 실행 결과}\label{Theoph_nlr}}
 ## [11]  0.04519
 ## 
 ## $`Elapsed Time`
-## Time difference of 0.021 secs
+## Time difference of 0.006914 secs
 ## 
 ## [1] "## ID = 12 ##"
 ## $Est
@@ -4762,7 +4772,7 @@ \chapter{Theoph의 nlr의 전체 실행 결과}\label{Theoph_nlr}}
 ## [11] -0.02175
 ## 
 ## $`Elapsed Time`
-## Time difference of 0.013 secs
+## Time difference of 0.005691 secs
 \end{verbatim}
 
 \normalsize
@@ -4812,8 +4822,7 @@ \chapter*{참고문헌}\label{uxcc38uxace0uxbb38uxd5cc}}
 Obach, R Scott, Franco Lombardo, and Nigel J Waters. 2008. {``Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 670 Drug Compounds.''} \emph{Drug Metabolism and Disposition} 36 (7): 1385--405.
 
 \leavevmode\vadjust pre{\hypertarget{ref-R-psych}{}}%
-Revelle, William. 2021. \emph{Psych: Procedures for Psychological, Psychometric, and Personality Research}. \href{https://personality-project.org/r/psych/\%0Ahttps://personality-project.org/r/psych-manual.pdf}{https://personality-project.org/r/psych/
-https://personality-project.org/r/psych-manual.pdf}.
+Revelle, William. 2021. \emph{Psych: Procedures for Psychological, Psychometric, and Personality Research}. \url{https://personality-project.org/r/psych-manual.pdf}.
 
 \leavevmode\vadjust pre{\hypertarget{ref-richens1975serum}{}}%
 Richens, Alan, and Andrew Dunlop. 1975. {``Serum-Phenytoin Levels in Management of Epilepsy.''} \emph{The Lancet} 306 (7928): 247--48.