diff --git a/test/BUILD b/test/BUILD
index 216d6e2..108ddae 100644
--- a/test/BUILD
+++ b/test/BUILD
@@ -202,3 +202,14 @@ python_test(
     ],
     labels = ["manual"],
 )
+
+plugin_e2e_test(
+    name = "interpreter_options_test",
+    repo = "interpreter_options_repo",
+    test_cmd = [
+        "plz run //:binary > binary",
+    ],
+    expected_output = {
+        "binary": "Executed plzmodule.py",
+    },
+)
diff --git a/test/interpreter_options_repo/.plzconfig b/test/interpreter_options_repo/.plzconfig
new file mode 100644
index 0000000..2ffad3a
--- /dev/null
+++ b/test/interpreter_options_repo/.plzconfig
@@ -0,0 +1,2 @@
+[Plugin "python"]
+Target = //plugins:python
diff --git a/test/interpreter_options_repo/BUILD_FILE b/test/interpreter_options_repo/BUILD_FILE
new file mode 100644
index 0000000..94913ca
--- /dev/null
+++ b/test/interpreter_options_repo/BUILD_FILE
@@ -0,0 +1,16 @@
+subinclude("///python//build_defs:python")
+
+package(
+    # If InterpreterOptions is being honoured, the Python interpreter should execute plzmodule.py
+    # as the __main__ module instead of main.py, causing "Executed plzmodule.py" to be printed on
+    # stdout rather than "Executed binary.py".
+    python = {
+        "interpreter_options": ["-m", "plzmodule"],
+    },
+)
+
+python_binary(
+    name = "binary",
+    main = "binary.py",
+    srcs = ["plzmodule.py"],
+)
diff --git a/test/interpreter_options_repo/binary.py b/test/interpreter_options_repo/binary.py
new file mode 100644
index 0000000..c16be82
--- /dev/null
+++ b/test/interpreter_options_repo/binary.py
@@ -0,0 +1,2 @@
+if __name__ == "__main__":
+    print("Executed binary.py")
diff --git a/test/interpreter_options_repo/plugins/BUILD_FILE b/test/interpreter_options_repo/plugins/BUILD_FILE
new file mode 100644
index 0000000..bd8b3fd
--- /dev/null
+++ b/test/interpreter_options_repo/plugins/BUILD_FILE
@@ -0,0 +1,4 @@
+plugin_repo(
+    name = "python",
+    revision = "e2e",
+)
diff --git a/test/interpreter_options_repo/plzmodule.py b/test/interpreter_options_repo/plzmodule.py
new file mode 100644
index 0000000..4e61a7d
--- /dev/null
+++ b/test/interpreter_options_repo/plzmodule.py
@@ -0,0 +1,2 @@
+if __name__ == "__main__":
+    print("Executed plzmodule.py")