diff --git a/vcpkg/ports/py-setuptools/fix-prefix.patch b/vcpkg/ports/py-setuptools/fix-prefix.patch
new file mode 100644
index 000000000000..13f8af9ce524
--- /dev/null
+++ b/vcpkg/ports/py-setuptools/fix-prefix.patch
@@ -0,0 +1,61 @@
+diff --git a/setuptools/_distutils/command/build_ext.py b/setuptools/_distutils/command/build_ext.py
+index 06d949a..0dee0fe 100644
+--- a/setuptools/_distutils/command/build_ext.py
++++ b/setuptools/_distutils/command/build_ext.py
+@@ -209,6 +209,14 @@ class build_ext(Command):
+         elif isinstance(self.rpath, str):
+             self.rpath = self.rpath.split(os.pathsep)
+ 
++        prefix = os.path.normpath(sys.prefix)
++        vcpkg_prefix = os.path.dirname(os.path.dirname(prefix)) # Add debug compile?
++
++        if self.debug:
++            self.library_dirs.append(os.path.join(vcpkg_prefix, 'debug', 'lib'))
++        else:
++            self.library_dirs.append(os.path.join(vcpkg_prefix, 'lib'))
++
+         # for extensions under windows use different directories
+         # for Release and Debug builds.
+         # also Python's library directory must be appended to library_dirs
+@@ -216,9 +224,9 @@ class build_ext(Command):
+             # the 'libs' directory is for binary installs - we assume that
+             # must be the *native* platform.  But we don't really support
+             # cross-compiling via a binary install anyway, so we let it go.
+-            self.library_dirs.append(os.path.join(sys.exec_prefix, 'libs'))
+-            if sys.base_exec_prefix != sys.prefix:  # Issue 16116
+-                self.library_dirs.append(os.path.join(sys.base_exec_prefix, 'libs'))
++            # self.library_dirs.append(os.path.join(sys.exec_prefix, 'libs'))
++            # if sys.base_exec_prefix != sys.prefix:  # Issue 16116
++            #    self.library_dirs.append(os.path.join(sys.base_exec_prefix, 'libs'))
+             if self.debug:
+                 self.build_temp = os.path.join(self.build_temp, "Debug")
+             else:
+diff --git a/setuptools/_distutils/sysconfig.py b/setuptools/_distutils/sysconfig.py
+index 1a38e9f..2c8174d 100644
+--- a/setuptools/_distutils/sysconfig.py
++++ b/setuptools/_distutils/sysconfig.py
+@@ -191,18 +191,21 @@ def _get_python_inc_from_config(plat_specific, spec_prefix):
+ def _get_python_inc_posix_prefix(prefix):
+     implementation = 'pypy' if IS_PYPY else 'python'
+     python_dir = implementation + get_python_version() + build_flags
+-    return os.path.join(prefix, "include", python_dir)
++    vcpkg_prefix = os.path.dirname(os.path.dirname(prefix))
++    return os.path.join(vcpkg_prefix, "include", python_dir)
+ 
+ 
+ def _get_python_inc_nt(prefix, spec_prefix, plat_specific):
++    vcpkg_prefix = os.path.dirname(os.path.dirname(prefix))
++    python_dir = 'python' + get_python_version()
+     if python_build:
+         # Include both include dirs to ensure we can find pyconfig.h
+         return (
+-            os.path.join(prefix, "include")
++            os.path.join(vcpkg_prefix, "include", python_dir)
+             + os.path.pathsep
+             + os.path.dirname(sysconfig.get_config_h_filename())
+         )
+-    return os.path.join(prefix, "include")
++    return os.path.join(vcpkg_prefix, "include", python_dir)
+ 
+ 
+ # allow this behavior to be monkey-patched. Ref pypa/distutils#2.
diff --git a/vcpkg/ports/py-setuptools/portfile.cmake b/vcpkg/ports/py-setuptools/portfile.cmake
new file mode 100644
index 000000000000..1df3e6ebeee3
--- /dev/null
+++ b/vcpkg/ports/py-setuptools/portfile.cmake
@@ -0,0 +1,18 @@
+vcpkg_from_pythonhosted(
+    OUT_SOURCE_PATH SOURCE_PATH
+    PACKAGE_NAME        setuptools
+    VERSION         ${VERSION}
+    SHA512          d0a34f16dfa6bb9a6df39076cd43528cf854d343f6f801c448ea0ebab2a259aec3d03571e2a26709df6082ed2fcb6c43b86448be556fd559b6af41831b4f38e0
+    PATCHES 
+      fix-prefix.patch
+)
+
+vcpkg_python_build_and_install_wheel(SOURCE_PATH "${SOURCE_PATH}")
+
+set(VCPKG_POLICY_EMPTY_INCLUDE_FOLDER enabled)
+
+vcpkg_install_copyright(FILE_LIST "${SOURCE_PATH}/LICENSE")
+#execute_process(COMMAND ${PYTHON3} "${SOURCE_PATH}/setup.py" install "--prefix=${CURRENT_INSTALLED_DIR}/tools/python3" "--root=${CURRENT_PACKAGES_DIR}"
+#  COMMAND_ERROR_IS_FATAL ANY
+#  WORKING_DIRECTORY  "${CURRENT_PACKAGES_DIR}/tools/python3"
+#)
diff --git a/vcpkg/ports/py-setuptools/vcpkg.json b/vcpkg/ports/py-setuptools/vcpkg.json
new file mode 100644
index 000000000000..b98586c650be
--- /dev/null
+++ b/vcpkg/ports/py-setuptools/vcpkg.json
@@ -0,0 +1,16 @@
+{
+  "name": "py-setuptools",
+  "version": "72.1.0",
+  "description": "Official project repository for the Setuptools build system ",
+  "homepage": "https://pypi.org/project/setuptools/",
+  "license": "MIT",
+  "dependencies": [
+    "py-packaging",
+    "py-wheel",
+    "python3",
+    {
+      "name": "vcpkg-python-scripts",
+      "host": true
+    }
+  ]
+}