diff --git a/cmake/modules/RootMacros.cmake b/cmake/modules/RootMacros.cmake
index 87c95d2e7ddf3..1fc36f5899169 100644
--- a/cmake/modules/RootMacros.cmake
+++ b/cmake/modules/RootMacros.cmake
@@ -2482,8 +2482,7 @@ endfunction(ROOTTEST_ADD_AUTOMACROS)
 #-------------------------------------------------------------------------------
 #
 # macro ROOTTEST_COMPILE_MACRO(<filename> [BUILDOBJ object] [BUILDLIB lib]
-#                                         [FIXTURES_SETUP ...] [FIXTURES_CLEANUP ...] [FIXTURES_REQUIRED ...]
-#                                         [EXTRA_RPATHS ...])
+#                                         [FIXTURES_SETUP ...] [FIXTURES_CLEANUP ...] [FIXTURES_REQUIRED ...])
 #
 # This macro creates and loads a shared library containing the code from
 # the file <filename>. A test that performs the compilation is created.
@@ -2493,7 +2492,7 @@ endfunction(ROOTTEST_ADD_AUTOMACROS)
 #
 #-------------------------------------------------------------------------------
 macro(ROOTTEST_COMPILE_MACRO filename)
-  CMAKE_PARSE_ARGUMENTS(ARG "" "BUILDOBJ;BUILDLIB" "FIXTURES_SETUP;FIXTURES_CLEANUP;FIXTURES_REQUIRED;EXTRA_RPATHS"  ${ARGN})
+  CMAKE_PARSE_ARGUMENTS(ARG "" "BUILDOBJ;BUILDLIB" "FIXTURES_SETUP;FIXTURES_CLEANUP;FIXTURES_REQUIRED"  ${ARGN})
 
   # Add defines to root_compile_macro, in order to have out-of-source builds
   # when using the scripts/build.C macro.
@@ -2508,18 +2507,11 @@ macro(ROOTTEST_COMPILE_MACRO filename)
   endforeach()
 
   cmake_path(CONVERT "${CMAKE_CURRENT_BINARY_DIR}" TO_NATIVE_PATH_LIST NATIVE_BINARY_DIR)
-  if(ARG_EXTRA_RPATHS)
-    set(extra_rpaths)
-    foreach(rpath ${ARG_EXTRA_RPATHS})
-      list(APPEND extra_rpaths -e "gSystem->SetMakeSharedLib(TString{gSystem->GetMakeSharedLib()}.ReplaceAll(\"$RPath\", \"$RPath -Wl,-rpath,${rpath}\"))")
-    endforeach()
-  endif()
   set(root_compile_macro ${CMAKE_COMMAND} -E env
       ROOT_LIBRARY_PATH=${NATIVE_BINARY_DIR}
       ROOT_INCLUDE_PATH=${CMAKE_CURRENT_BINARY_DIR}:${DEFAULT_ROOT_INCLUDE_PATH}
       ${ROOT_root_CMD}
       -e "gSystem->SetBuildDir(\"${CMAKE_CURRENT_BINARY_DIR}\", true)"
-      ${extra_rpaths}
       ${RootMacroDirDefines}
       -q -b
   )
diff --git a/core/base/src/TSystem.cxx b/core/base/src/TSystem.cxx
index 018ea869ed8eb..9df99712e9c0c 100644
--- a/core/base/src/TSystem.cxx
+++ b/core/base/src/TSystem.cxx
@@ -3736,7 +3736,12 @@ int TSystem::CompileMacro(const char *filename, Option_t *opt,
    cmd.ReplaceAll("\"$BuildDir","$BuildDir");
    cmd.ReplaceAll("$BuildDir","\"$BuildDir\"");
    cmd.ReplaceAll("$BuildDir",build_loc);
-   cmd.ReplaceAll("$RPath", "-Wl,-rpath," + gROOT->GetSharedLibDir());
+   // Add relevant directories to RPATH:
+   // - Directory with all the ROOT libraries.
+   // - Directory where this shared library is being created. This enables creating multiple
+   //   libraries via ACLiC in the same session and have them depend on each other without
+   //   the need to set further environment variables.
+   cmd.ReplaceAll("$RPath", "-Wl,-rpath," + gROOT->GetSharedLibDir() + " -Wl,-rpath," + build_loc);
    TString optdebFlags;
    if (mode & kDebug)
       optdebFlags = fFlagsDebug + " ";
diff --git a/roottest/root/io/arrayobject/CMakeLists.txt b/roottest/root/io/arrayobject/CMakeLists.txt
index 2aaf64961bb64..60efffe130f1a 100644
--- a/roottest/root/io/arrayobject/CMakeLists.txt
+++ b/roottest/root/io/arrayobject/CMakeLists.txt
@@ -3,13 +3,11 @@ ROOTTEST_COMPILE_MACRO(foo.C
 
 ROOTTEST_COMPILE_MACRO(bar.C
                        BUILDLIB foo_C
-                       EXTRA_RPATHS ${CMAKE_CURRENT_BINARY_DIR}
                        FIXTURES_REQUIRED root-io-arrayobject-foo-fixture
                        FIXTURES_SETUP root-io-arrayobject-bar-fixture)
 
 ROOTTEST_COMPILE_MACRO(main.C
                        BUILDLIB bar_C
-                       EXTRA_RPATHS ${CMAKE_CURRENT_BINARY_DIR}
                        FIXTURES_REQUIRED root-io-arrayobject-bar-fixture
                        FIXTURES_SETUP root-io-arrayobject-main-fixture)