diff --git a/.github/workflows/bump-version.yml b/.github/workflows/bump-version.yml
index 8083fa8a43..cfd178cac4 100644
--- a/.github/workflows/bump-version.yml
+++ b/.github/workflows/bump-version.yml
@@ -204,8 +204,9 @@ jobs:
 
     - name: Install Python dependencies
       run: |
-        python -m pip install --upgrade pip setuptools wheel
-        python -m pip install tbump
+        python -m pip install uv
+        uv pip install --system --upgrade pip setuptools wheel
+        uv pip install --system tbump
         python -m pip list
 
     - name: Setup Git user to push new tag
diff --git a/.github/workflows/ci-windows.yml b/.github/workflows/ci-windows.yml
index c9f3e8e68b..696fadc5a4 100644
--- a/.github/workflows/ci-windows.yml
+++ b/.github/workflows/ci-windows.yml
@@ -29,8 +29,9 @@ jobs:
 
     - name: Install dependencies
       run: |
-        python -m pip install --upgrade pip setuptools wheel
-        python -m pip install --upgrade '.[all,test]'
+        python -m pip install uv
+        uv pip install --system --upgrade pip setuptools wheel
+        uv pip install --system --upgrade '.[all,test]'
 
     - name: List installed Python packages
       run: python -m pip list
diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 2d1c3f3217..82a92e10fb 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -44,6 +44,15 @@ jobs:
         python-version: ${{ matrix.python-version }}
 
     - name: Install dependencies
+      if: matrix.python-version != '3.8'
+      run: |
+        python -m pip install uv
+        uv pip install --system --upgrade pip setuptools wheel
+        uv pip install --system --upgrade ".[all,test]"
+
+      # c.f. https://github.com/astral-sh/uv/issues/2062
+    - name: Install dependencies (Python 3.8)
+      if: matrix.python-version == '3.8'
       run: |
         python -m pip install --upgrade pip setuptools wheel
         python -m pip install --upgrade ".[all,test]"
diff --git a/.github/workflows/dependencies-head.yml b/.github/workflows/dependencies-head.yml
index 96f1863760..849cf6fea4 100644
--- a/.github/workflows/dependencies-head.yml
+++ b/.github/workflows/dependencies-head.yml
@@ -29,8 +29,9 @@ jobs:
 
     - name: Install dependencies
       run: |
-        python -m pip install --upgrade pip setuptools wheel
-        python -m pip --no-cache-dir --quiet install --upgrade --pre ".[all,test]"
+        python -m pip install uv
+        uv pip install --system --upgrade pip setuptools wheel
+        uv pip --no-cache --quiet install --system --upgrade --pre ".[all,test]"
         python -m pip list
 
     - name: List release candidates, alpha, and beta releases
@@ -57,14 +58,14 @@ jobs:
       with:
         python-version: ${{ matrix.python-version }}
 
-    # Use nightly SciPy wheels from Anaconda's PyPI
-    # c.f. https://twitter.com/ralfgommers/status/1419917265781334025
     - name: Install dependencies
       run: |
-        python -m pip install --upgrade pip setuptools wheel
-        python -m pip --no-cache-dir --quiet install --upgrade ".[all,test]"
-        python -m pip uninstall --yes scipy
-        python -m pip install --upgrade --index-url https://pypi.anaconda.org/scientific-python-nightly-wheels/simple scipy
+        python -m pip install uv
+        uv pip install --system --upgrade pip setuptools wheel
+        uv pip --no-cache --quiet install --system --upgrade ".[all,test]"
+        uv pip uninstall --system scipy
+        # uv wants to upgrade dependencies (numpy) to a dev release too, so don't --upgrade
+        uv pip install --system --index-url https://pypi.anaconda.org/scientific-python-nightly-wheels/simple scipy
         python -m pip list
 
     - name: Test with pytest
@@ -87,11 +88,12 @@ jobs:
         python-version: ${{ matrix.python-version }}
     - name: Install dependencies
       run: |
-        python -m pip install --upgrade pip setuptools wheel
-        python -m pip --no-cache-dir --quiet install --upgrade ".[all,test]"
-        python -m pip uninstall --yes iminuit
-        python -m pip install --upgrade cython
-        python -m pip install --upgrade git+https://github.com/scikit-hep/iminuit.git
+        python -m pip install uv
+        uv pip install --system --upgrade pip setuptools wheel
+        uv pip --no-cache --quiet install --system --upgrade ".[all,test]"
+        uv pip uninstall --system iminuit
+        uv pip install --system --upgrade cython
+        uv pip install --system --upgrade git+https://github.com/scikit-hep/iminuit.git
         python -m pip list
     - name: Test with pytest
       run: |
@@ -113,10 +115,11 @@ jobs:
         python-version: ${{ matrix.python-version }}
     - name: Install dependencies
       run: |
-        python -m pip install --upgrade pip setuptools wheel
-        python -m pip --no-cache-dir --quiet install --upgrade ".[all,test]"
-        python -m pip uninstall --yes uproot
-        python -m pip install --upgrade git+https://github.com/scikit-hep/uproot5.git
+        python -m pip install uv
+        uv pip install --system --upgrade pip setuptools wheel
+        uv pip --no-cache --quiet install --system --upgrade ".[all,test]"
+        uv pip uninstall --system uproot
+        uv pip install --system --upgrade git+https://github.com/scikit-hep/uproot5.git
         python -m pip list
     - name: Test with pytest
       run: |
@@ -140,16 +143,18 @@ jobs:
 
     - name: Install dependencies
       run: |
-        python -m pip install --upgrade pip setuptools wheel
-        python -m pip --no-cache-dir --quiet install --upgrade ".[all,test]"
-        python -m pip uninstall --yes matplotlib
-        # Need to use --extra-index-url as dependencies aren't on scientific-python-nightly-wheels package index.
+        python -m pip install uv
+        uv pip install --system --upgrade pip setuptools wheel
+        uv pip --no-cache --quiet install --system --upgrade ".[all,test]"
+        uv pip uninstall --system matplotlib
+        # Need to use --extra-index-url as all dependencies aren't on scientific-python-nightly-wheels package index.
         # Need to use --pre as dev releases will need priority over stable releases.
-        python -m pip install \
-          --upgrade \
+        # Note that uv and pip differ on --extra-index-url priority
+        # c.f. https://github.com/scientific-python/upload-nightly-action/issues/76
+        uv pip install --system \
           --pre \
-          --index-url https://pypi.anaconda.org/scientific-python-nightly-wheels/simple \
-          --extra-index-url https://pypi.org/simple/ \
+          --index-url https://pypi.org/simple/ \
+          --extra-index-url https://pypi.anaconda.org/scientific-python-nightly-wheels/simple \
           matplotlib
 
     - name: List installed Python packages
@@ -175,10 +180,11 @@ jobs:
         python-version: ${{ matrix.python-version }}
     - name: Install dependencies
       run: |
-        python -m pip install --upgrade pip setuptools wheel
-        python -m pip --no-cache-dir --quiet install --upgrade ".[all,test]"
-        python -m pip uninstall --yes pytest
-        python -m pip install --upgrade git+https://github.com/pytest-dev/pytest.git
+        python -m pip install uv
+        uv pip install --system --upgrade pip setuptools wheel
+        uv pip --no-cache --quiet install --system --upgrade ".[all,test]"
+        uv pip uninstall --system pytest
+        uv pip install --system --upgrade git+https://github.com/pytest-dev/pytest.git
         python -m pip list
     - name: Test with pytest
       run: |
diff --git a/.github/workflows/docs.yml b/.github/workflows/docs.yml
index 155100d0ed..0bb1bc4315 100644
--- a/.github/workflows/docs.yml
+++ b/.github/workflows/docs.yml
@@ -28,9 +28,10 @@ jobs:
 
     - name: Install Python dependencies
       run: |
-        python -m pip install --upgrade pip setuptools wheel
-        python -m pip --quiet install --upgrade .[docs,test]
-        python -m pip install yq
+        python -m pip install uv
+        uv pip install --system --upgrade pip setuptools wheel
+        uv pip --quiet install --system --upgrade ".[docs,test]"
+        uv pip install --system yq
         python -m pip list
 
     - name: Install apt-get dependencies
diff --git a/.github/workflows/lower-bound-requirements.yml b/.github/workflows/lower-bound-requirements.yml
index 96b5c6a3d8..e9ebdbaa86 100644
--- a/.github/workflows/lower-bound-requirements.yml
+++ b/.github/workflows/lower-bound-requirements.yml
@@ -26,8 +26,9 @@ jobs:
 
     - name: Install dependencies and force lowest bound
       run: |
-        python -m pip install --upgrade pip setuptools wheel
-        python -m pip --no-cache-dir install --constraint tests/constraints.txt ".[all,test]"
+        python -m pip install uv
+        uv pip install --system --upgrade pip setuptools wheel
+        uv pip --no-cache install --system --constraint tests/constraints.txt ".[all,test]"
 
     - name: List installed Python packages
       run: python -m pip list
diff --git a/.github/workflows/notebooks.yml b/.github/workflows/notebooks.yml
index 7ab2b048f8..8278f2abdc 100644
--- a/.github/workflows/notebooks.yml
+++ b/.github/workflows/notebooks.yml
@@ -28,9 +28,10 @@ jobs:
 
     - name: Install dependencies
       run: |
-        python -m pip install --upgrade pip setuptools wheel
+        python -m pip install uv
+        uv pip install --system --upgrade pip setuptools wheel
         # FIXME: c.f. https://github.com/scikit-hep/pyhf/issues/2104
-        python -m pip install --upgrade ".[all,test]" 'jupyter-client<8.0.0'
+        uv pip install --system --upgrade ".[all,test]" 'jupyter-client<8.0.0'
 
     - name: List installed Python packages
       run: python -m pip list
diff --git a/.github/workflows/publish-package.yml b/.github/workflows/publish-package.yml
index cd5d4a9ba7..38b455e8b5 100644
--- a/.github/workflows/publish-package.yml
+++ b/.github/workflows/publish-package.yml
@@ -43,19 +43,20 @@ jobs:
 
     - name: Install python-build and twine
       run: |
-        python -m pip install --upgrade pip
-        python -m pip install build twine
+        python -m pip install uv
+        uv pip install --system --upgrade pip
+        uv pip install --system build twine
         python -m pip list
 
     - name: Build a sdist and wheel
       if: github.event_name != 'schedule'
       run: |
-        python -m build .
+        python -m build --installer uv .
 
     - name: Build a sdist and wheel and check for warnings
       if: github.event_name == 'schedule'
       run: |
-        PYTHONWARNINGS=error,default::DeprecationWarning python -m build .
+        PYTHONWARNINGS=error,default::DeprecationWarning python -m build --installer uv .
 
     - name: Verify untagged commits have dev versions
       if: "!startsWith(github.ref, 'refs/tags/')"
diff --git a/.github/workflows/release_tests.yml b/.github/workflows/release_tests.yml
index 83b42ef02a..2d3f2e8bd5 100644
--- a/.github/workflows/release_tests.yml
+++ b/.github/workflows/release_tests.yml
@@ -36,9 +36,10 @@ jobs:
 
     - name: Install from PyPI
       run: |
-        python -m pip install --upgrade pip setuptools wheel
-        python -m pip install --pre 'pyhf[backends,xmlio]'
-        python -m pip install pytest
+        python -m pip install uv
+        uv pip install --system --upgrade pip setuptools wheel
+        uv pip install --system --pre 'pyhf[backends,xmlio]'
+        uv pip install --system pytest
         python -m pip list
 
     - name: Canary test public API
@@ -48,6 +49,6 @@ jobs:
       # FIXME: c.f. https://github.com/proycon/codemetapy/issues/24
     - name: Verify requirements in codemeta.json
       run: |
-        python -m pip install jq "codemetapy>=2.3.0"
+        uv pip install --system jq "codemetapy>=2.3.0"
         codemetapy --inputtype python --no-extras pyhf > codemeta_generated.json
         diff <(jq -S .softwareRequirements codemeta.json) <(jq -S .softwareRequirements codemeta_generated.json)
diff --git a/.readthedocs.yaml b/.readthedocs.yaml
index bd5f4ea9cd..6ff1c4c8b8 100644
--- a/.readthedocs.yaml
+++ b/.readthedocs.yaml
@@ -21,7 +21,7 @@ sphinx:
 # If using Sphinx, optionally build your docs in additional formats such as PDF and ePub
 formats: all
 
-# python -m pip install .[docs]
+# python -m pip install '.[docs]'
 python:
   install:
     - method: pip
diff --git a/pyproject.toml b/pyproject.toml
index 7af3b92123..8aad3f9850 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -134,6 +134,7 @@ develop = [
     "pre-commit",
     "nox",
     "codemetapy>=2.3.0",
+    "uv>=0.1.39"
 ]
 
 [tool.hatch.version]