Currently the CF integration uses the SERVERLESS_REGION variable that is not set by default. That means that you have to set it manually for each region.
As most users would use the lambda context's region it would be better to set this as default. Then serverless' environment variables would stay clean. Technically the lambda region can be retrieved from the AWS SDK.
An optional parameter could be added to CF.loadVars() to cover the remaining corner cases where you do not want to use the default.