diff --git a/accounts/usbwallet/ledger.go b/accounts/usbwallet/ledger.go
index cda94280fdd2..723df0f2b352 100644
--- a/accounts/usbwallet/ledger.go
+++ b/accounts/usbwallet/ledger.go
@@ -59,6 +59,8 @@ const (
 	ledgerP1InitTransactionData     ledgerParam1 = 0x00 // First transaction data block for signing
 	ledgerP1ContTransactionData     ledgerParam1 = 0x80 // Subsequent transaction data block for signing
 	ledgerP2DiscardAddressChainCode ledgerParam2 = 0x00 // Do not return the chain code along with the address
+
+	ledgerEip155Size int = 3 // Size of the EIP-155 chain_id,r,s in unsigned transactions
 )
 
 // errLedgerReplyInvalidHeader is the error message returned by a Ledger data exchange
@@ -347,9 +349,15 @@ func (w *ledgerDriver) ledgerSign(derivationPath []uint32, tx *types.Transaction
 		op    = ledgerP1InitTransactionData
 		reply []byte
 	)
+
+	// Chunk size selection to mitigate an underlying RLP deserialization issue on the ledger app.
+	// https://github.com/LedgerHQ/app-ethereum/issues/409
+	chunk := 255
+	for ; len(payload)%chunk <= ledgerEip155Size; chunk-- {
+	}
+
 	for len(payload) > 0 {
 		// Calculate the size of the next data chunk
-		chunk := 255
 		if chunk > len(payload) {
 			chunk = len(payload)
 		}