diff --git a/src/Providers/ExtensionServiceProvider.php b/src/Providers/ExtensionServiceProvider.php
index 2d1043f343f..3ae1bc8789b 100644
--- a/src/Providers/ExtensionServiceProvider.php
+++ b/src/Providers/ExtensionServiceProvider.php
@@ -252,6 +252,7 @@ class ExtensionServiceProvider extends ServiceProvider
         Updates\AddTimezoneConfigOptions::class,
         Updates\RemoveParentField::class,
         Updates\UpdateGlobalVariables::class,
+        Updates\PublishMigrationForNocacheUrlColumn::class,
         Updates\PublishMigrationForTwoFactorColumns::class,
         Updates\PublishMigrationForWebauthnTable::class,
         Updates\AddAddonSettingsToGitConfig::class,
diff --git a/src/StaticCaching/NoCache/DatabaseSession.php b/src/StaticCaching/NoCache/DatabaseSession.php
index 08029ff51ad..c5b14b76851 100644
--- a/src/StaticCaching/NoCache/DatabaseSession.php
+++ b/src/StaticCaching/NoCache/DatabaseSession.php
@@ -11,7 +11,7 @@ public function write()
 
     public function restore()
     {
-        $regions = DatabaseRegion::where('url', $this->url)->get(['key']);
+        $regions = DatabaseRegion::where('url', md5($this->url))->get(['key']);
 
         $this->regions = $regions->map->key;
 
@@ -38,7 +38,7 @@ protected function cacheRegion(Region $region)
         DatabaseRegion::updateOrCreate([
             'key' => $region->key(),
         ], [
-            'url' => $this->url,
+            'url' => md5($this->url),
             'region' => serialize($region),
         ]);
     }
diff --git a/src/UpdateScripts/PublishMigrationForNocacheUrlColumn.php b/src/UpdateScripts/PublishMigrationForNocacheUrlColumn.php
new file mode 100644
index 00000000000..900259b70e8
--- /dev/null
+++ b/src/UpdateScripts/PublishMigrationForNocacheUrlColumn.php
@@ -0,0 +1,40 @@
+<?php
+
+namespace Statamic\UpdateScripts;
+
+use Illuminate\Support\Facades\File;
+use Illuminate\Support\Str;
+
+class PublishMigrationForNocacheUrlColumn extends UpdateScript
+{
+    public function shouldUpdate($newVersion, $oldVersion)
+    {
+        return $this->isUpdatingTo('6.0.0')
+            && config('statamic.static_caching.nocache', 'cache') === 'database';
+    }
+
+    public function update()
+    {
+        if (! $this->migrationExists('update_nocache_url_column')) {
+            $stub = __DIR__.'/stubs/update_nocache_url_column.php.stub';
+            $filename = date('Y_m_d_His').'_update_nocache_url_column.php';
+
+            File::put(database_path("migrations/$filename"), File::get($stub));
+
+            $this->console->line(sprintf(
+                'Migration <info>database/migrations/%s</info> created successfully.',
+                $filename
+            ));
+
+            $this->console->line('Run <comment>php artisan migrate</comment> to apply the migration.');
+        }
+    }
+
+    protected function migrationExists(string $name): bool
+    {
+        return collect(File::allFiles(database_path('migrations')))
+            ->map->getFilename()
+            ->filter(fn (string $filename) => Str::contains($filename, $name))
+            ->isNotEmpty();
+    }
+}
diff --git a/src/UpdateScripts/stubs/update_nocache_url_column.php.stub b/src/UpdateScripts/stubs/update_nocache_url_column.php.stub
new file mode 100644
index 00000000000..f1d954d05ae
--- /dev/null
+++ b/src/UpdateScripts/stubs/update_nocache_url_column.php.stub
@@ -0,0 +1,29 @@
+<?php
+
+use Illuminate\Database\Migrations\Migration;
+use Illuminate\Support\Facades\DB;
+
+return new class extends Migration
+{
+    /**
+     * Run the migrations.
+     */
+    public function up(): void
+    {
+        DB::transaction(function () {
+            DB::connection(config('statamic.static_caching.nocache_db_connection'))
+                ->table('nocache_regions')
+                ->whereLike('url', 'http%')
+                ->orderBy('key')
+                ->chunk(100, function ($regions) {
+                    foreach ($regions as $region) {
+                        DB::connection(config('statamic.static_caching.nocache_db_connection'))
+                            ->table('nocache_regions')
+                            ->where('key', $region->key)
+                            ->where('url', $region->url)
+                            ->update(['url' => md5($region->url)]);
+                    }
+                });
+        });
+    }
+};