Gene overlap matrix from top 100 candidates identified by Univariate F-Regression
String network from top candidate genes
This gene family is expressed during brain development, but are also expressed in some tissues in adults. It is thought that they may regulate cell differentiation, tissue regeneration and tissue maintenance. They are sensitive to long range epigenetic silencing and hypermethylation of thesec PCDH clusters has been identified in breast cancer, cervical cancer, colorectal cancers, uterine leiomyosarcoma and leiomyoma, and in Wilms’ tumor. Pancho et al. Protocadherins at the Crossroad of Signaling Pathways. Front Mol Neurosci. 2020. https://doi.org/10.3389/fnmol.2020.00117
Higher level of HOXA7 has been shown is some studies to be associated with poor prognosis and increased tumor growth and metastasis. It is thought that the mechanism may be involved in epithelial to mesenchymal transition. Tang et al. HOXA7 plays a critical role in metastasis of liver cancer associated with activation of Snail. 2016. Molecular Cancer 15:57. https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-016-0540-4
SLC45A2-AMACR gene fusion has been shown to be associated with increased risk of prostate cancer recurrence, metastases, and/or death. Yu et al. Novel Fusion Transcripts Associate with Progressive Prostate Cancer. Am J Pathol. 2014 Oct; 184(10): 2840–2849. https://doi.org/10.1016/j.ajpath.2014.06.025