unloved-crouton.yml

unique-id: unloved-crouton
phe-label: V-21FEB-02
alternate-names:
- VOC202102/02
- Bristol
- VOC1 + E484K
belongs-to-lineage:
- PANGO: B.1.1.7
description: This variant is a cluster of B.1.1.7 (VOC202012/01) that contains E484K and is associated with the Bristol area
information-sources:
-
variants:
- codon-change: AAC-AAT
  gene: ORF1ab
  one-based-reference-position: 7843
  predicted-effect: synonymous
  protein: nsp3
  protein-codon-position: 1708
  reference-base: C
  type: SNP
  variant-base: T
- amino-acid-change: E484K
  codon-change: GAA-AAA
  gene: S
  one-based-reference-position: 23012
  predicted-effect: non-synonymous
  protein: surface glycoprotein
  protein-codon-position: 484
  reference-base: G
  type: SNP
  variant-base: A
- codon-change: GAC-GAT
  gene: M
  one-based-reference-position: 27092
  predicted-effect: synonymous
  protein: membrane glycoprotein
  protein-codon-position: 190
  reference-base: C
  type: SNP
  variant-base: T
- amino-acid-change: A173V
  codon-change: GCA-GTA
  gene: N
  one-based-reference-position: 28791
  predicted-effect: non-synonymous
  protein: nucleocapsid phosphoprotein
  protein-codon-position: 173
  reference-base: C
  type: SNP
  variant-base: T
- amino-acid-change: A398T
  codon-change: GCA-ACA
  gene: N
  one-based-reference-position: 29465
  predicted-effect: non-synonymous
  protein: nucleocapsid phosphoprotein
  protein-codon-position: 398
  reference-base: G
  type: SNP
  variant-base: A
calling-definition:
  confirmed:
    mutations-required: 5
    indels-required: 0
    allowed-wildtype: 0
  low-qc:
    mutations-required: 0
    indels-required: 0
    allowed-wildtype: 0
acknowledgements:
curators:
- Natalie Groves
- Ulf Schaefer
- Nick Loman