diff --git a/openapi.yaml b/openapi.yaml
index a7aa3e8..f3964eb 100644
--- a/openapi.yaml
+++ b/openapi.yaml
@@ -81,12 +81,19 @@ paths:
           nullable: true
       - name: match_
         in: query
-        description: The match mode.
+        description: The match mode, default is `Match::Exact`.
         required: false
         schema:
           allOf:
           - $ref: '#/components/schemas/Match'
           nullable: true
+      - name: ignore_case
+        in: query
+        description: Whether case is insentivie, default is `false`.
+        required: false
+        schema:
+          type: boolean
+          nullable: true
       - name: max_results
         in: query
         description: Maximal number of results to return.
diff --git a/src/server/run/hpo_omims.rs b/src/server/run/hpo_omims.rs
index 6efc642..ea4fbaa 100644
--- a/src/server/run/hpo_omims.rs
+++ b/src/server/run/hpo_omims.rs
@@ -39,9 +39,11 @@ pub struct Query {
     pub omim_id: Option<String>,
     /// The disease name to search for.
     pub name: Option<String>,
-    /// The match mode.
+    /// The match mode, default is `Match::Exact`.
     #[serde(alias = "match")]
     pub match_: Option<Match>,
+    /// Whether case is insentivie, default is `false`.
+    pub ignore_case: Option<bool>,
     /// Maximal number of results to return.
     #[serde(default = "_default_max_results")]
     pub max_results: usize,
@@ -144,6 +146,7 @@ pub struct Result {
 
 /// Query for OMIM diseases in the HPO database.
 #[allow(clippy::unused_async)]
+#[allow(clippy::too_many_lines)]
 #[utoipa::path(
     operation_id = "hpo_omims",
     params(Query),
@@ -167,11 +170,22 @@ async fn handle(
                 .map_err(|e| CustomError::new(anyhow::anyhow!(e)))?;
             ontology.omim_disease(&omim_id)
         } else if let Some(name) = &query.name {
+            let name = if query.ignore_case.unwrap_or_default() {
+                name.to_lowercase()
+            } else {
+                name.clone()
+            };
             let mut omim_disease = None;
             let mut it = ontology.omim_diseases();
             let mut tmp = it.next();
             while tmp.is_some() && omim_disease.is_none() {
-                if tmp.expect("checked above").name() == name {
+                let tmp_name = tmp.expect("checked above").name();
+                let tmp_name = if query.ignore_case.unwrap_or_default() {
+                    tmp_name.to_lowercase()
+                } else {
+                    tmp_name.to_string()
+                };
+                if tmp_name == name {
                     omim_disease = tmp;
                 }
                 tmp = it.next();
@@ -191,11 +205,21 @@ async fn handle(
         let mut it = ontology.omim_diseases();
         let mut omim_disease = it.next();
         while omim_disease.is_some() && result.len() < query.max_results {
+            let name = if query.ignore_case.unwrap_or_default() {
+                name.to_lowercase()
+            } else {
+                name.clone()
+            };
             let omim_name = omim_disease.as_ref().expect("checked above").name();
+            let omim_name = if query.ignore_case.unwrap_or_default() {
+                omim_name.to_lowercase()
+            } else {
+                omim_name.to_string()
+            };
             let is_match = match query.match_.unwrap_or_default() {
-                Match::Prefix => omim_name.starts_with(name),
-                Match::Suffix => omim_name.ends_with(name),
-                Match::Contains => omim_name.contains(name),
+                Match::Prefix => omim_name.starts_with(&name),
+                Match::Suffix => omim_name.ends_with(&name),
+                Match::Contains => omim_name.contains(&name),
                 Match::Exact => panic!("cannot happen here"),
             };
             if is_match {
diff --git a/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_contains_no_hpo_terms.snap b/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_contains_no_hpo_terms.snap
index bf6fad2..cfe4f6c 100644
--- a/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_contains_no_hpo_terms.snap
+++ b/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_contains_no_hpo_terms.snap
@@ -9,6 +9,7 @@ query:
   omim_id: ~
   name: tel-Manzke syndro
   match_: contains
+  ignore_case: ~
   max_results: 100
   hpo_terms: false
 result:
diff --git a/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_contains_with_hpo_terms.snap b/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_contains_with_hpo_terms.snap
index a99d788..48ecb3d 100644
--- a/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_contains_with_hpo_terms.snap
+++ b/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_contains_with_hpo_terms.snap
@@ -9,6 +9,7 @@ query:
   omim_id: ~
   name: tel-Manzke syndro
   match_: contains
+  ignore_case: ~
   max_results: 100
   hpo_terms: true
 result:
diff --git a/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_exact_no_hpo_terms.snap b/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_exact_no_hpo_terms.snap
index 33a14ad..21e40b4 100644
--- a/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_exact_no_hpo_terms.snap
+++ b/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_exact_no_hpo_terms.snap
@@ -9,6 +9,7 @@ query:
   omim_id: ~
   name: Catel-Manzke syndrome
   match_: ~
+  ignore_case: ~
   max_results: 100
   hpo_terms: false
 result:
diff --git a/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_exact_with_hpo_terms.snap b/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_exact_with_hpo_terms.snap
index f78af79..c06ceb6 100644
--- a/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_exact_with_hpo_terms.snap
+++ b/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_exact_with_hpo_terms.snap
@@ -9,6 +9,7 @@ query:
   omim_id: ~
   name: Catel-Manzke syndrome
   match_: ~
+  ignore_case: ~
   max_results: 100
   hpo_terms: true
 result:
diff --git a/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_prefix_no_hpo_terms.snap b/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_prefix_no_hpo_terms.snap
index 42dae91..7abe192 100644
--- a/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_prefix_no_hpo_terms.snap
+++ b/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_prefix_no_hpo_terms.snap
@@ -9,6 +9,7 @@ query:
   omim_id: ~
   name: Catel-Manzke syndro
   match_: prefix
+  ignore_case: ~
   max_results: 100
   hpo_terms: false
 result:
diff --git a/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_prefix_with_hpo_terms.snap b/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_prefix_with_hpo_terms.snap
index 9022e08..d06e83a 100644
--- a/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_prefix_with_hpo_terms.snap
+++ b/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_prefix_with_hpo_terms.snap
@@ -9,6 +9,7 @@ query:
   omim_id: ~
   name: Catel-Manzke syndro
   match_: prefix
+  ignore_case: ~
   max_results: 100
   hpo_terms: true
 result:
diff --git a/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_suffix_no_hpo_terms.snap b/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_suffix_no_hpo_terms.snap
index 223d861..2d4f4df 100644
--- a/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_suffix_no_hpo_terms.snap
+++ b/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_suffix_no_hpo_terms.snap
@@ -9,6 +9,7 @@ query:
   omim_id: ~
   name: tel-Manzke syndrome
   match_: suffix
+  ignore_case: ~
   max_results: 100
   hpo_terms: false
 result:
diff --git a/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_suffix_with_hpo_terms.snap b/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_suffix_with_hpo_terms.snap
index d2564bb..41196eb 100644
--- a/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_suffix_with_hpo_terms.snap
+++ b/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_name_suffix_with_hpo_terms.snap
@@ -9,6 +9,7 @@ query:
   omim_id: ~
   name: tel-Manzke syndrome
   match_: suffix
+  ignore_case: ~
   max_results: 100
   hpo_terms: true
 result:
diff --git a/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_omim_id_exact_no_hpo_terms.snap b/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_omim_id_exact_no_hpo_terms.snap
index e4852d9..484b0b3 100644
--- a/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_omim_id_exact_no_hpo_terms.snap
+++ b/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_omim_id_exact_no_hpo_terms.snap
@@ -9,6 +9,7 @@ query:
   omim_id: "616145"
   name: ~
   match_: ~
+  ignore_case: ~
   max_results: 100
   hpo_terms: false
 result:
diff --git a/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_omim_id_exact_with_hpo_terms.snap b/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_omim_id_exact_with_hpo_terms.snap
index e57a71f..83a2d7f 100644
--- a/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_omim_id_exact_with_hpo_terms.snap
+++ b/src/server/run/snapshots/viguno__server__run__hpo_omims__test__hpo_omims_omim_id_exact_with_hpo_terms.snap
@@ -9,6 +9,7 @@ query:
   omim_id: "616145"
   name: ~
   match_: ~
+  ignore_case: ~
   max_results: 100
   hpo_terms: true
 result: