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NeedlemanWunsch.sol
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NeedlemanWunsch.sol
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// SPDX-License-Identifier: MIT
// Created by ZENODE (zenodeapp - https://github.com/zenodeapp/)
/**********************************************************************************
* MIT License *
* Copyright (c) 2022 ZENODE *
* *
* Permission is hereby granted, free of charge, to any person obtaining a copy *
* of this software and associated documentation files (the "Software"), to deal *
* in the Software without restriction, including without limitation the rights *
* to use, copy, modify, merge, publish, distribute, sublicense, and/or sell *
* copies of the Software, and to permit persons to whom the Software is *
* furnished to do so, subject to the following conditions: *
* *
* The above copyright notice and this permission notice shall be included in all *
* copies or substantial portions of the Software. *
* *
* THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR *
* IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, *
* FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE *
* AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER *
* LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, *
* OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE *
* SOFTWARE. *
**********************************************************************************/
pragma solidity ^0.8.17;
import './_PairwiseAlignment.sol';
contract NeedlemanWunsch is PairwiseAlignment {
constructor(SubstitutionMatrices _matricesAddress) PairwiseAlignment(_matricesAddress) {}
function needlemanWunsch(string memory sequenceA, string memory sequenceB, int gap, uint limit, string memory matrix)
public view returns(AlignmentOutput memory) {
return _needlemanWunsch(sequenceA, sequenceB, AlignmentOptions(gap, limit, matrix));
}
function _needlemanWunsch(string memory sequenceA, string memory sequenceB, AlignmentOptions memory alignmentOptions)
public view returns(AlignmentOutput memory alignmentOutput) {
alignmentOptions = _before(sequenceA, sequenceB, alignmentOptions);
// Initialize matrices
(AlignmentData memory alignmentData, int[] memory scoreMatrix) = initializeMatrices(
sequenceA,
sequenceB,
alignmentOptions.gap,
[TracebackCommand.STOP, TracebackCommand.LEFT, TracebackCommand.UP]
);
// Score matrices
ScoreOptions memory scoreOptions;
scoreOptions.enableFloor = false;
alignmentData = scoreMatrices(scoreMatrix, alignmentData, alignmentOptions, scoreOptions);
// Get starting points (For Needleman-Wunsch there is only a single starting point)
uint[] memory startingPoints = new uint[](1);
startingPoints[0] = alignmentData.width * alignmentData.height - 1;
// Traceback
alignmentOutput.alignments = traceback(alignmentData, startingPoints, alignmentOptions.limit);
// Remaining output
alignmentOutput.sequenceA = sequenceA;
alignmentOutput.sequenceB = sequenceB;
alignmentOutput.score = scoreMatrix[startingPoints[0]];
alignmentOutput.count = alignmentOutput.alignments.length;
}
}