The following Python libraries are required.
1. Cooler (https://cooler.readthedocs.io/en/latest/index.html)
2. Pytorch
3. NumPy
4. Pandas
5. SciPy
6. einops (https://einops.rocks/)
Three parameters required:
python HiC2MicroC.py -f1 file1 -f2 file2 -f3 file3
- file1: a 5-kb Hi-C file in cool format
- file2: chromosome size file
- file3: output prefix
HiC2MicroC will generate file3.cool, which is our predicted Micro-C file.