Clarithromycin-Midazolam-DDI

Modeling of published clinical Clarithromycin-Midazolam-DDI studies for model evaluation

Repository files

Within this repository, we distribute a PK-Sim project file containing simulations of all published clinical studies used to evaluate the predictive performance of our models regarding the Clarithromycin-Midazolam-DDI, including the respective observed data digitized from literature reports. For further details and documentation please refer to [1].

Code of conduct

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Contribution

We encourage contribution to the Open Systems Pharmacology community. Before getting started please read the contribution guidelines. If you are contributing code, please be familiar with the coding standard.

License

The model code is distributed under the GPLv2 License.

Reference

[1] Hanke N, Frechen S, Moj D, Britz H, Eissing T, Wendl T, Lehr T. PBPK models for CYP3A4 and P-gp DDI prediction: a modeling network of rifampicin, itraconazole, clarithromycin, midazolam, alfentanil and digoxin. CPT: Pharmacometrics & Systems Pharmacology (2018), https://doi.org/10.1002/psp4.12343.