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# Welcome to CSB | ||
# CSB GitHub Org page | ||
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This is the GitHub organization for the **Computational Systems Biology** department of the RPTU Kaiserslautern. | ||
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You can read more about the following topics on our [website](https://csbiology.github.io/): | ||
- [research](https://csbiology.github.io/#research) | ||
- [teaching (university courses and projects)](https://csbiology.github.io/#teaching) | ||
- [publications](https://csbiology.github.io/#publication) | ||
- [team](https://csbiology.github.io/#team) | ||
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# Our Research | ||
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The capability of biological systems to respond to environmental changes is realized by a complex dynamic adjustment of the interplay between genes, proteins and metabolites. | ||
For a deeper understanding at the systems level, we need to study the structure and dynamics of cellular and organismal functions rather than the characteristics of isolated parts of a cell or an organism. | ||
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## Research data management (RDM) | ||
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We are committed to the success of FAIR (Findable, Accessible, Interoperable, and Reusable) and open research data. | ||
Research data possess immense value, which, when combined with tomorrow's technologies such as machine and deep learning, can unlock answers to questions we cannot even conceive today. | ||
Therefore, the flexible contextualization of research data with machine-actionable metadata is essential to advance modern science. | ||
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We draw inspiration from the open-source software community's success, developing approaches that enable the biological community to collaboratively build a community-wide FAIR research data resource. | ||
Our research group participates in the National Research Data Infrastructure (NFDI) initiative with the [DataPLANT project](https://github.com/nfdi4plants), which empowers plant researchers to engage in a thriving RDM ecosystem without barriers. | ||
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## Biological Data Science | ||
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Modern technologies now allow researchers to simultaneously study biological organisms and processes across various molecular layers and in diverse biological contexts. | ||
To leverage this wealth of data, we are developing advanced methods for both supervised and unsupervised analysis of multi-modal omics data using cutting-edge machine learning and statistical modeling techniques. | ||
As part of fslabs.org, we contribute to the open-source data analysis library environment, ensuring that our innovations are accessible to the broader research community. | ||
Our methods enable comprehensive, data-driven integration and analysis of data derived from multiple omics technologies and varied biological scenarios, thereby enhancing our understanding of complex biological systems. | ||
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## Prediction of acclimation modulators and integrators based on ‘omics data | ||
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Acclimation responses involve complex interactions among genes, proteins, and metabolites, resulting in both general and specific elements. | ||
Previously, we focused on extracting response-specific structural models from complex 'omics data using functional constraint aggregation and network topology inference. | ||
- `/profile/README.md` contains the content displayed at the org homepage | ||
- Discussions Tab is used for overall organization discussions (if needed) |