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feat: adapt wastewater story text
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resolves #1014
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fengelniederhammer committed Sep 4, 2024
1 parent 02e5878 commit 37b204c
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2 changes: 1 addition & 1 deletion src/models/wasteWater/constants.ts
Original file line number Diff line number Diff line change
Expand Up @@ -39,4 +39,4 @@ export const discontinuedLocations = new Set<string>([
'test_legacylocation', // for tests
]);

export const discontinuedDate = ' since Jan 1, 2024';
export const discontinuedDate = ' since March 26th, 2024';
49 changes: 27 additions & 22 deletions src/models/wasteWater/story/WasteWaterStoryPage.tsx
Original file line number Diff line number Diff line change
Expand Up @@ -16,15 +16,14 @@ export const WasteWaterStoryPage = () => {
<ExternalLink url='https://bsse.ethz.ch/cbg/'>Computational Biology Group, ETH Zurich</ExternalLink>
</div>
<p>
We analyze wastewater samples collected at different Swiss wastewater treatment plants ( see data
We analyze wastewater samples collected at different Swiss wastewater treatment plants (see data
sources below) using next-generation sequencing (done by{' '}
<ExternalLink url='https://fgcz.ch/'>FGCZ</ExternalLink>), process the resulting short-read data with{' '}
<ExternalLink url='https://cbg-ethz.github.io/V-pipe/'>V-pipe</ExternalLink>, and search for mutations
characteristic of several variants of concern. The relative frequency of each signature mutation is
determined, and all frequencies are combined per day, which provides an estimate of the relative
prevalence of the variant in the population. Some variants have specific signature mutations that
co-occur on the same fragment. Amplicons with such co-occurrences are included in the heatmaps of the
wastewater data displayed on covSpectrum (see{' '}
characteristic of variants of concern. The relative frequency of each signature mutation is
determined, and all mutation frequencies are combined within a selected time window and translated
into estimates of the relative prevalence of the variant in the population for each day. Some variants
have specific signature mutations that co-occur on the same fragment. (see{' '}
<ExternalLink url='https://doi.org/10.1101/2021.01.08.21249379'>
doi:10.1101/2021.01.08.21249379
</ExternalLink>
Expand All @@ -36,8 +35,9 @@ export const WasteWaterStoryPage = () => {
</p>
<p>
Detecting variants in wastewater is challenging if the RNA concentration is low, for example, due to
low infection numbers in the catchment area of the wastewater treatment plant. Estimates of the
proportions of variants are less reliable in this situation.
low infection numbers in the catchment area of the wastewater treatment plant. Variants with very
similar mutation profiles can also be harder to distinguish. Estimates of the proportions of variants
are less reliable in these situations.
</p>
<WasteWaterSamplingSites locationFilter={location => !isDiscontinuedSite(location)} />
<DiscontinuedSamplingSites />
Expand Down Expand Up @@ -68,14 +68,18 @@ const DataSources = () => {
<ExternalLink url={'https://www.eawag.ch/en/department/sww/projects/sars-cov2-in-wastewater/'}>
Eawag
</ExternalLink>{' '}
collects samples daily at multiple locations around Switzerland. Over the course of the project
different locations have been covered. Since January 1st of 2024 the following eight wastewater
treatment plants are monitored: Altenrhein (SG), Chur (GR), Genève (GE), Laupen (BE), Lugano (TI),
Zürich (ZH), Luzern (LU) and Bern (BE).
collects samples at multiple locations around Switzerland. Over the course of the project, different
locations have been covered. Since March 26th of 2024 the following eight wastewater treatment plants
are sampled three times per week: Altenrhein (SG), Chur (GR), Genève (GE), Laupen (BE), Lugano (TI),
Zürich (ZH), Luzern (LU) and Basel (BS).
</p>
<p>
Until end of December 2023 the project covered six additional wastewater treatment plants: Lausanne
(VD), Basel (BS), Porrentruy (JU), Neuchâtel (NE), Solothurn (SO) and Schwyz (SZ).
Previously, the project covered six additional wastewater treatment plants: Lausanne (VD), Bern (BE),
Porrentruy (JU), Neuchâtel (NE), Solothurn (SO), and Schwyz (SZ).
</p>
<p>
Monitoring of Bern (BE) ended on March 25th, 2024. Monitoring of Lausanne ended February 24th, 2024.
The monitoring of all other discontinued treatment plants ended on December 31st, 2023.
</p>
<p>
Previously, Microsynth AG provided samples from the wastewater treatment plants of Lausanne (Vidy),
Expand All @@ -86,7 +90,7 @@ const DataSources = () => {
three times per week (once per week until the end of 2022).
</p>
<p>
Until end of May 2022 three times a week the Cantonal Laboratory Zurich (KLZH) provided samples that
Until end of May 2022, three times a week the Cantonal Laboratory Zurich (KLZH) provided samples that
assess the Canton of Zurich by pooling samples from 12 plants across the canton, namely
Zürich-Werdhölzli (also used by Eawag), Winterthur-Hard, Dietikon-Limmattal, Dübendorf-Neugut,
Niederglatt-Fischbach, Uster, Bülach-Furt, Wetzikon-Flos, Horgen-Oberrieden, Meilen, Affoltern
Expand Down Expand Up @@ -118,7 +122,7 @@ const VideoPresentation = () => {
<ExternalLink url={'https://iwa-network.org/learn/detecting-covid-19-variants-in-wastewater/'}>
"Detecting COVID-19 Variants in Wastewater" by the International Water Association (IWA)
</ExternalLink>
, Prof. Tamar Kohn and Prof. Niko Beerenwinkel have presented this surveillance project. The
, Prof. Tamar Kohn, and Prof. Niko Beerenwinkel have presented this surveillance project. The
presentation is the second session of this webinar,
<ExternalLink url={'https://vimeo.com/560055953#t=1337s'}>
"Detection and surveillance of SARS-CoV-2 genomic variants in Swiss wastewater" (timecode 22:17).
Expand All @@ -135,7 +139,7 @@ const Acknowledgements = () => {
<h2>Acknowledgements</h2>
<h3>
<ExternalLink url={'https://bsse.ethz.ch/cbg'}>
Computational Biology Group (CBG), ETH Zürich{' '}
Computational Biology Group (CBG), ETH Zurich{' '}
</ExternalLink>{' '}
/{' '}
<ExternalLink url={'https://www.sib.swiss/niko-beerenwinkel-group'}>
Expand All @@ -144,12 +148,12 @@ const Acknowledgements = () => {
</h3>
<Authors
authors={
'Ivan Topolsky, David Dreifuss, Anika John, Auguste Rimaite, Pelin Burcak Icer, Lara Fuhrmann, Kim Philipp Jablonski, Niko Beerenwinkel'
'Ivan Topolsky, David Dreifuss, Anika John, Auguste Rimaite, Pelin Burcak Icer, Lara Fuhrmann, Niko Beerenwinkel'
}
/>
<h3>
<ExternalLink url={'https://bsse.ethz.ch/cevo'}>
Computational Evolution (cEvo), ETH Zürich
Computational Evolution (cEvo), ETH Zurich
</ExternalLink>{' '}
/{' '}
<ExternalLink url={'https://www.sib.swiss/tanja-stadler-group'}>
Expand All @@ -159,7 +163,7 @@ const Acknowledgements = () => {
<Authors authors={'Chaoran Chen, Sarah Nadeau, Tanja Stadler'} />
<h3>
<ExternalLink url={'https://www.nexus.ethz.ch/'}>
NEXUS Personalized Health Technologies, ETH Zürich
NEXUS Personalized Health Technologies, ETH Zurich
</ExternalLink>{' '}
/{' '}
<ExternalLink url={'https://www.sib.swiss/daniel-stekhoven-group'}>
Expand Down Expand Up @@ -200,8 +204,9 @@ const Contact = () => {
return (
<div>
<h2>Contact</h2>
<ExternalLink url={'https://bsse.ethz.ch/cbg'}>Computational Biology, D-BSSE, ETHZ.</ExternalLink> Niko
Beerenwinkel,
<p>
Prof. Niko Beerenwinkel, <ExternalLink url='https://bsse.ethz.ch/cbg'>ETH</ExternalLink> Zurich.
</p>
</div>
);
};

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