Predicting tissue distribution of highly lipophilic compounds.
Poulin, P.; Haddad, S. Advancing Prediction of Tissue Distribution and Volume of Distribution of Highly Lipophilic Compounds from a Simplified Tissue-Composition-Based Model as a Mechanistic Animal Alternative Method. J. Pharm. Sci. 2012, 101, 2250–2261.
- Microsoft Windows 7 or later
- Microsoft Office 2010 or later
- Microsoft .NET 4+
Download the latest build from releases.
Two XLL files are present in the zip archive for a release. The build (32-bit or 64-bit) of Microsoft Office installed will detemine which of the XLL files should be installed.
To install the XLL, refer to Add or remove an Excel add-in on this Microsoft Office support page.
Refer to Poulin & Haddad to determine whether the model implemented in this add-in is applicable to your problem domain.
In a worksheet cell, use the Vss function. The three arguments required are:
- Log octanol:water partition coefficient, log Pow
- Ionization class (N, WB, SB, A, or Z)
- Does drug chemical structure consist of at least one oxygen atom? (TRUE or FALSE)
If the drug or chemical is not neutral (not class N), supply a fourth argument:
- pKa
If the drug or chemical is a zwitterion (class Z), supply a fifth argument:
- pKa,base
Example:
=Vss(7.23, "N", TRUE)
To view other functions available with this add-in, in the Excel function wizard, select Poulin Haddad from the Category drop-down.