Skip to content

Commit

Permalink
Merge pull request #432 from Hjorthmedh/neuromod_redux2
Browse files Browse the repository at this point in the history
Small RxD fixes etc
  • Loading branch information
Hjorthmedh authored Oct 25, 2024
2 parents 252e983 + 2e1f7a2 commit 7b2805f
Show file tree
Hide file tree
Showing 61 changed files with 245,513 additions and 31,271 deletions.
1,083 changes: 1,081 additions & 2 deletions examples/notebooks/StriatumExample/CreateStriatum.ipynb

Large diffs are not rendered by default.

Original file line number Diff line number Diff line change
@@ -1,10 +1,10 @@
{
"0": {
"time": [0, 0.5, 1, 10],
"current": [0, 600e-12, 0, 0]
"time": [0, 10],
"current": [700e-12, 700e-12]
},
"1": {
"time": [0, 0.5, 1, 10],
"current": [0, 500e-12, 0, 0]
"time": [0, 10],
"current": [600e-12, 600e-12]
}
}
Original file line number Diff line number Diff line change
@@ -1,190 +1,190 @@
{
"species": {
"GaolfGDP": {
"initial_concentration": 1.0083120895466201e-11,
"initial_concentration": 1.0083120895162319e-11,
"diffusion_constant": 0,
"charge": 0,
"regions": [
"soma_internal",
"dend_internal"
],
"concentration": 1.0083120895466201e-11,
"concentration": 1.0083120895162319e-11,
"boundary_condition": false
},
"Gbgolf": {
"initial_concentration": 2.98851246006536e-08,
"initial_concentration": 2.988512460154891e-08,
"diffusion_constant": 0,
"charge": 0,
"regions": [
"soma_internal",
"dend_internal"
],
"concentration": 2.98851246006536e-08,
"concentration": 2.988512460154891e-08,
"boundary_condition": false
},
"GaolfGTP": {
"initial_concentration": 8.91348109605658e-12,
"initial_concentration": 8.913481096069321e-12,
"diffusion_constant": 0,
"charge": 0,
"regions": [
"soma_internal",
"dend_internal"
],
"concentration": 8.91348109605658e-12,
"concentration": 8.913481096069321e-12,
"boundary_condition": false
},
"D1RDAGolf": {
"initial_concentration": 2.00890216216344e-09,
"initial_concentration": 2.0089021621627304e-09,
"diffusion_constant": 0,
"charge": 0,
"regions": [
"soma_internal",
"dend_internal"
],
"concentration": 2.00890216216344e-09,
"concentration": 2.0089021621627304e-09,
"boundary_condition": false
},
"Golf": {
"initial_concentration": 1.4530725722822101e-06,
"initial_concentration": 1.4530725722815221e-06,
"diffusion_constant": 0,
"charge": 0,
"regions": [
"soma_internal",
"dend_internal"
],
"concentration": 1.4530725722822101e-06,
"concentration": 1.4530725722815221e-06,
"boundary_condition": false
},
"D1RGolf": {
"initial_concentration": 5.150334009549751e-07,
"initial_concentration": 5.150334009547925e-07,
"diffusion_constant": 0,
"charge": 0,
"regions": [
"soma_internal",
"dend_internal"
],
"concentration": 5.150334009549751e-07,
"concentration": 5.150334009547925e-07,
"boundary_condition": false
},
"D1RDA": {
"initial_concentration": 5.95922532787641e-09,
"initial_concentration": 5.959225327877092e-09,
"diffusion_constant": 0,
"charge": 0,
"regions": [
"soma_internal",
"dend_internal"
],
"concentration": 5.95922532787641e-09,
"concentration": 5.959225327877092e-09,
"boundary_condition": false
},
"D1R": {
"initial_concentration": 1.47699847155499e-06,
"initial_concentration": 1.476998471555163e-06,
"diffusion_constant": 0,
"charge": 0,
"regions": [
"soma_internal",
"dend_internal"
],
"concentration": 1.47699847155499e-06,
"concentration": 1.476998471555163e-06,
"boundary_condition": false
},
"cAMP": {
"initial_concentration": 3.81860143351998e-08,
"initial_concentration": 3.81860143351498e-08,
"diffusion_constant": 0,
"charge": 0,
"regions": [
"soma_internal",
"dend_internal"
],
"concentration": 3.81860143351998e-08,
"concentration": 3.81860143351498e-08,
"boundary_condition": false
},
"AC5": {
"initial_concentration": 2.66944644058834e-09,
"initial_concentration": 2.6694464405835234e-09,
"diffusion_constant": 0,
"charge": 0,
"regions": [
"soma_internal",
"dend_internal"
],
"concentration": 2.66944644058834e-09,
"concentration": 2.6694464405835234e-09,
"boundary_condition": false
},
"AC5GaolfGTP": {
"initial_concentration": 1.1809040707886602e-10,
"initial_concentration": 1.1809040798642496e-10,
"diffusion_constant": 0,
"charge": 0,
"regions": [
"soma_internal",
"dend_internal"
],
"concentration": 1.1809040707886602e-10,
"concentration": 1.1809040798642496e-10,
"boundary_condition": false
},
"PDE4": {
"initial_concentration": 1.50680848289944e-06,
"initial_concentration": 1.506808482899933e-06,
"diffusion_constant": 0,
"charge": 0,
"regions": [
"soma_internal",
"dend_internal"
],
"concentration": 1.50680848289944e-06,
"concentration": 1.506808482899933e-06,
"boundary_condition": false
},
"PKA": {
"initial_concentration": 1.15714133868944e-06,
"initial_concentration": 1.157141338689479e-06,
"diffusion_constant": 0,
"charge": 0,
"regions": [
"soma_internal",
"dend_internal"
],
"concentration": 1.15714133868944e-06,
"concentration": 1.157141338689479e-06,
"boundary_condition": false
},
"PKAcAMP2": {
"initial_concentration": 3.2824343126378e-09,
"initial_concentration": 3.2824343126336076e-09,
"diffusion_constant": 0,
"charge": 0,
"regions": [
"soma_internal",
"dend_internal"
],
"concentration": 3.2824343126378e-09,
"concentration": 3.2824343126336076e-09,
"boundary_condition": false
},
"PKAcAMP4": {
"initial_concentration": 8.673741393198342e-11,
"initial_concentration": 8.673741393175797e-11,
"diffusion_constant": 0,
"charge": 0,
"regions": [
"soma_internal",
"dend_internal"
],
"concentration": 8.673741393198342e-11,
"concentration": 8.673741393175797e-11,
"boundary_condition": false
},
"PKAreg": {
"initial_concentration": 3.9489489583994e-08,
"initial_concentration": 3.9489489583984004e-08,
"diffusion_constant": 0,
"charge": 0,
"regions": [
"soma_internal",
"dend_internal"
],
"concentration": 3.9489489583994e-08,
"concentration": 3.9489489583984004e-08,
"boundary_condition": false
},
"PKAc": {
"initial_concentration": 3.6607805792436603e-09,
"initial_concentration": 3.66078057923442e-09,
"diffusion_constant": 0,
"charge": 0,
"regions": [
"soma_internal",
"dend_internal"
],
"concentration": 3.6607805792436603e-09,
"concentration": 3.66078057923442e-09,
"boundary_condition": false
},
"DA": {
Expand All @@ -210,58 +210,58 @@
"boundary_condition": true
},
"PDE4_cAMP": {
"initial_concentration": 4.931915171005611e-07,
"initial_concentration": 4.931915171000725e-07,
"diffusion_constant": 0,
"charge": 0,
"regions": [
"soma_internal",
"dend_internal"
],
"concentration": 4.931915171005611e-07,
"concentration": 4.931915171000725e-07,
"boundary_condition": false
},
"PDE10c": {
"initial_concentration": 5.78101285574062e-10,
"initial_concentration": 5.781012855729472e-10,
"diffusion_constant": 0,
"charge": 0,
"regions": [
"soma_internal",
"dend_internal"
],
"concentration": 5.78101285574062e-10,
"concentration": 5.781012855729472e-10,
"boundary_condition": false
},
"PDE10": {
"initial_concentration": 3.96456253552482e-07,
"initial_concentration": 3.9645625355276524e-07,
"diffusion_constant": 0,
"charge": 0,
"regions": [
"soma_internal",
"dend_internal"
],
"concentration": 3.96456253552482e-07,
"concentration": 3.9645625355276524e-07,
"boundary_condition": false
},
"PDE10_cAMP": {
"initial_concentration": 3.0278168362869404e-07,
"initial_concentration": 3.0278168362851246e-07,
"diffusion_constant": 0,
"charge": 0,
"regions": [
"soma_internal",
"dend_internal"
],
"concentration": 3.0278168362869404e-07,
"concentration": 3.0278168362851246e-07,
"boundary_condition": false
},
"PDE10c_cAMP": {
"initial_concentration": 1.8396153325001302e-10,
"initial_concentration": 1.8396153315047553e-10,
"diffusion_constant": 0,
"charge": 0,
"regions": [
"soma_internal",
"dend_internal"
],
"concentration": 1.8396153325001302e-10,
"concentration": 1.8396153315047553e-10,
"boundary_condition": false
},
"ATP": {
Expand All @@ -276,25 +276,25 @@
"boundary_condition": true
},
"AC5GaolfGTP_ATP": {
"initial_concentration": 2.97480375915836e-08,
"initial_concentration": 2.9748037591572225e-08,
"diffusion_constant": 0,
"charge": 0,
"regions": [
"soma_internal",
"dend_internal"
],
"concentration": 2.97480375915836e-08,
"concentration": 2.9748037591572225e-08,
"boundary_condition": false
},
"AC5_ATP": {
"initial_concentration": 6.6746442556075e-07,
"initial_concentration": 6.674644255598668e-07,
"diffusion_constant": 0,
"charge": 0,
"regions": [
"soma_internal",
"dend_internal"
],
"concentration": 6.6746442556075e-07,
"concentration": 6.674644255598668e-07,
"boundary_condition": false
}
},
Expand Down
Original file line number Diff line number Diff line change
Expand Up @@ -3,6 +3,7 @@
"output_file": "networks/neuromodulation_bath_current/simulation/output_neuromodulation_OFF.hdf5",
"log_file": "networks/neuromodulation_bath_current/log/network-simulation-OFF.txt",
"time": 1.5,
"!sim_dt": 0.005,
"record_all_soma": true,
"record_rxd_species_all": [0, 1],
"record_density_mechanism": {
Expand Down
Original file line number Diff line number Diff line change
@@ -0,0 +1,42 @@
{
"network_file": "networks/neuromodulation_bath_current/network-synapses.hdf5",
"output_file": "networks/neuromodulation_bath_current/simulation/output_neuromodulation_ON.hdf5",
"log_file": "networks/neuromodulation_bath_current/log/network-simulation-ON.txt",
"time": 20,
"sim_dt": 0.001,
"record_all_soma": true,
"record_rxd_species_soma": [0, 1],
"record_density_mechanism": {
"kir_ms.modulation_factor": {
"neuron_id": [0, 1],
"section_id": [-1, -1],
"section_x": [0.5, 0.5]
},
"naf_ms.modulation_factor": {
"neuron_id": [0, 1],
"section_id": [-1, -1],
"section_x": [0.5, 0.5]
},
"kaf_ms.modulation_factor_g": {
"neuron_id": [0, 1],
"section_id": [-1, -1],
"section_x": [0.5, 0.5]
},
"kaf_ms.modulation_factor_shift": {
"neuron_id": [0, 1],
"section_id": [-1, -1],
"section_x": [0.5, 0.5]
}
},
"rxd_enable_extracellular": false,
"bath_application": {
"DA": {
"Xtime": [0, 2.499, 2.5, 2.99, 3.0, 3.5, 3.51, 4, 4.01, 20],
"Xconcentration": [1e-6, 1e-6, 0, 0, 60e-6, 60e-6, 100e-6, 100e-6, 0, 0],
"time": [0, 100],
"concentration": [1e-6, 1e-6],
"interpolate": true
}
},
"current_injection_file": "bath_current_injection.json"
}
Loading

0 comments on commit 7b2805f

Please sign in to comment.