3.17

Features

Issue key	Summary
NIR-678	Update OMIM to the August 2021 version
NIR-674	Update ClinVar to the August 2021 version
NIR-671	Optimize memory for JSON outputs

Bugs fixed

Issue key	Summary
NIR-724	Buffer overrun in BgzipTextWriter
NIR-663	Nirvana λ is unable to handle empty VCF files
NIR-549	JWT validator doesn't work for api regions
NIR-212	Annotation lambdas run out of disk space when large amounts of CA are submitted

Unresolved bugs

Issue key	Summary
NIR-759	Nirvana lambda throws Nirvana error when signature expires
NIR-703	Nirvana incorrectly handles deletions across the terminal codon in HGVS p.
NIR-702	Nirvana should stop after inserted terminal codon in HGVS p.
NIR-701	Nirvana should simplify HGVS p. notation for deletions that disrupt the initiation codon
NIR-667	Nirvana is unable to count the # of AA until new stop codon (HGVS p. frameshift)
NIR-666	Nirvana creates frameshift HGVS p. notation when extension is expected
NIR-665	Nirvana uses incorrect HGVS p. notation for disrupted translation initiation codons
NIR-602	SAUtils CustomVar won't allow missing values for Score columns
NIR-582	Jasix incorrectly closes the JSON header when combining query with header
NIR-504	SingleAnnotation behaves differently in Lambda vs REST API
NIR-479	Single Annotation lambda should handle incorrect alt alleles more robustly
NIR-220	Incorrect HGVS p. results because Nirvana does not use the transcript sequence
NIR-219	Nirvana reports incorrect HGVS p. for non-AUG start codon variants
NIR-215	Nirvana incorrectly determines gnomAD low complexity regions at translocation breakend boundaries
NIR-86	Nirvana incorrectly handles insertions where RNA-edit insertions already occur
NIR-56	CDS position goes beyond the CDS sequence length (NM_001300952.1)