LivingPark is a project to improve the generalizability and robustness of MRI-derived biomarkers of Parkinson's Disease through analytical and data variability evaluations. It started in March 2022 and is currently funded by the Michael J Fox Foundation. The first objective of the project is to replicate the following MRI measures of Parkinson's Disease and make them available as Jupyter Notebooks.
We'd love to hear from you! Feel free to reach out by posting an issue in any of our repos, or by email at livingpark@lists.concordia.ca
The following table points to the on-going replication efforts.
| Reference | Person in charge | Notebook | Limitations | External review | Authors feedback | Extension to QPN |
|---|---|---|---|---|---|---|
| C. Scherfler et al., 2011. | @glatard |  |
No major limitation identified | |||
| S. Rahayel et al., 2018. | @niyonx | |
Sample size in RDB-MCI group | |||
| Y. Zeighami et al., 2015. | Niusha | https://github.com/LivingPark-MRI/zeighami-etal-2015 | No major limitation identified | On-going | ||
| Y. Zeighami et al., 2019. | @michellewang | |
No major limitation identified | On-going | ||
| E. Mak et al., 2015. | @chelsieng / @ansokolowski | |
Sample size | |||
| C. Tessa et al., 2014. | Jacob | |
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| E. Mak et al., 2017. | @mathdugre | |
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| F. Agosta et al., 2013. | @glatard | |
need to check p-value thresholds | |||
| Z. Shu et al., 2021. | @mohanadarafe | |
No major limitation identified | |||
| N. W. Sterling et al., 2016. | @rmanaem | https://github.com/LivingPark-MRI/sterling-etal-2016 | ||||
| A. Hanganu et al., 2014. | @ansokolowski | |
Sample size | On-going |
To facilitate the development of these notebooks we develop livingpark-utils, a collection of functions to help work with PPMI data. We also develop ppmi-scraper, a set of utilities to download PPMI study and imaging data.