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fix figure number reference
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nicolerg committed Sep 30, 2024
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Expand Up @@ -40,7 +40,7 @@ knitr::opts_chunk$set(

This report was motivated by this reviewer comment regarding our [*Nature* publication](https://www.nature.com/articles/s41586-023-06877-w):

**Reviewer 1:** Given the extensive collection of metabolomics data (targeted and untargeted) for so many tissues and temporal timepoints (Figure 1C) it will be interesting to explore the changes of several key cellular metabolites in addition to the KEGG pathways. For example, it will be interesting to see sex- and time-specific changes in the plasma, muscles, heart of such metabolites as glucose, pyruvate, lactate, acetate, perhaps key intermediates of glycolysis and the TCA cycle. If the data is available, it will be also interesting to characterize the changes in the energy and redox ratios, i.e. ATP/ADP, NADH/NAD+ (or individual concentrations, such as ATP). Given the central roles of these metabolites in cellular physiology/health and multiple changes in the corresponding metabolic pathways (Figure 7), it will be good to present and discuss the observed metabolic changes.
**Reviewer 1:** Given the extensive collection of metabolomics data (targeted and untargeted) for so many tissues and temporal timepoints (Figure 1C) it will be interesting to explore the changes of several key cellular metabolites in addition to the KEGG pathways. For example, it will be interesting to see sex- and time-specific changes in the plasma, muscles, heart of such metabolites as glucose, pyruvate, lactate, acetate, perhaps key intermediates of glycolysis and the TCA cycle. If the data is available, it will be also interesting to characterize the changes in the energy and redox ratios, i.e. ATP/ADP, NADH/NAD+ (or individual concentrations, such as ATP). Given the central roles of these metabolites in cellular physiology/health and multiple changes in the corresponding metabolic pathways ([Figure 6]), it will be good to present and discuss the observed metabolic changes.

```{r setup, message = FALSE, warning = FALSE}
library(MotrpacRatTraining6mo)
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