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Calyx of Held, short term plasticity (Yang Z et al. 2009)

modeldb.science/118554

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Name		Name	Last commit message	Last commit date
Latest commit History 1 Commit
expdata		expdata
coh_stoch_mod.m		coh_stoch_mod.m
inhpoiss.m		inhpoiss.m
inhreg.m		inhreg.m
readme.html		readme.html
run_model.m		run_model.m
screenshot.jpg		screenshot.jpg

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<html><pre>
Stochastic model of STP at the Calyx of Held
--------------------------------------------

This model investigates mechanisms contributing to short term
plasticity at the calyx of Held, a giant glutamatergic synapse
in the mammalian brainstem auditory system. It is a stochastic
version of the model described in:
 
Hennig, M., Postlethwaite, M., Forsythe, I.D. and Graham, B.P. (2007). 
A biophysical model of short-term plasticity at the calyx of Held. 
Neurocomputing, 70:1626-1629.

This version introduces stochastic vesicle recycling and release.
It has been used to investigate the information transmission
properties of this synapse, as detailed in:

Yang, Z., Hennig, M., Postlethwaite, M., Forsythe, I.D. and Graham, B.P. (2008). 
Wide-band information transmission at the calyx of Held. 
Neural Computation, 21(4):991-1018.

The model is written in Matlab. The provided main file runs the
model for 1 second of simulated time with stimulation by regular
frequencies of 10, 20, 50 and 100Hz, for comparison with
experimental data from the calyx.  A graph similar to Figure 1 from
the paper is created:

<img src="./screenshot.jpg" alt=screenshot">

Main file: run_model.m

Model file: coh_stoch_mod.m

Stimulation file: inhreg.m

Experimental data in expdata folder.

These model files supplied by Bruce Graham.
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