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T-type Calcium currents (McRory et al 2001)
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NEURON mod files for CaT currents from the paper: McRory et al., J.Biol.Chem. 276:3999 (2001). Running the kinetics.hoc simulation file will show the activation and inactivation steady-states and time constants of the three members of the LVA calcium channels family studied in this paper (alpha-1G, -1H, and -1I), with kinetic parameters from functional expression in transfected cells. Parameters for activation/inactivation are from the paper. However, not all the parameters used to fit (with single exponentials) the experimental values for the time constants were given in the paper. Those explicitly reported were used to constrain a fit of experimental values derived from Fig.6. Ca++ reversal potential is calculated from Nerst equation, using internal and external Ca++ concentrations. Default values are [Ca]i=50nM and [Ca]o=2mM. Under unix systems: to compile the mod files use the command nrnivmodl and run the simulation hoc file with the command nrngui kinetics.hoc Under Windows: to compile the mod files use the "mknrndll" command. A double click on the simulation file kinetics.hoc will open the simulation window. Questions on the model parameters should be directed to the authors of paper. Questions on how to use this model with NEURON should be directed to michele@pa.ibf.cnr.it
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T-type Calcium currents (McRory et al 2001)
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