GitHub - ModelDBRepository/247713: A multiscale approach to analyze circadian rhythms (Vasalou & Henson, 2010) (CellML)

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A multiscale approach to analyze circadian rhythms (Vasalou & Henson, 2010) (CellML)

modeldb.science/247713

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<html>
  The models for the paper:<p>

    Vasalou C, Henson MA (2010) A multiscale model to investigate
    circadian rhythmicity of pacemaker neurons in the suprachiasmatic
    nucleus.
    <a href="http://dx.doi.org/10.1371/journal.pcbi.1000706">PLoS Comput Biol</a> 6:e1000706
    [<a href="https://www.ncbi.nlm.nih.gov/pubmed?holding=modeldb&term=20300645">PubMed</a>]
  <p/>
  are available at the cellml.org website (translated from SBML from biomodels):<p/>
  <a href="https://models.cellml.org/e/25/vasalou_2010.cellml/view">https://models.cellml.org/e/25/vasalou_2010.cellml/view</a>
  <p/>

  <p/> Example: To recreate a few traces in opencor from figure 2 in the paper, change the ending point to 100 hours and the interval point to 0.1 hours. The 100 hours lets the model stabilize. Create a few graphs (use "+" sign) and then populate the graphs by selecting a graph by clicking on it, and adding to one of each by right-clicking IK, ICa, and fr (firing rate) under the membrane list, and select Plot against integration variable. Running (click upper left play triangle) creates the following graph contain a few traces from figure 2<p/>
  
  <img src="./screenshot.png" alt="screenshot" width="550"><p/>
  (Above traces are IK, ICa, and firing rate respectively plotted vs hours. Each cycle is 24 hours.)
</html>