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CA3 hippocampal pyramidal neuron with voltage-clamp intrinsic conductance data (Traub et al 1991)
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<!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.01//EN" "http://www.w3.org/TR/html4/strict.dtd"> <html> <head> <meta http-equiv="Content-Type" content="text/html; charset=utf-8"> <meta http-equiv="Content-Style-Type" content="text/css"> <title></title> <meta name="Generator" content="Cocoa HTML Writer"> <meta name="CocoaVersion" content="1404.47"> <style type="text/css"> p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Helvetica} p.p2 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Helvetica; min-height: 14.0px} </style> </head> <body> <p class="p1">This is a NEURON version of the CA3 pyramidal cell model of Traub et al. 1991 (J. Neurophysiol. 66(2): 635-650).</p> <p class="p2"><br></p> <p class="p1">The Bash shell script MakeSpecial.sh will create the special executable with the required mechanisms to simulate the model. Location: subdirectory x86_64 (created after running MakeSpecial.sh). This assumes NEURON is installed and nrnivmodl is in the executable PATH.</p> <p class="p2"><br></p> <p class="p1">Run the following command from the root directory for a graphical interface allowing to generate each figure:<span class="Apple-converted-space"> </span></p> <p class="p2"><br></p> <p class="p1">./x86_64/special mosinit.hoc -</p> <p class="p2"><br></p> <p class="p1">Alternatively, each of the files GenerateFigX.hoc (where X = 3, 4, … 10) will generate the data for the corresponding figure in Traub et al. (1991):</p> <p class="p2"><br></p> <p class="p1">./x86_64/special GenerateFigX.hoc -</p> <p class="p2"><br></p> <p class="p1">To plot the results, start Matlab, switch to the appropriate figure directory, for example for figure 3:</p> <p class="p2"><br></p> <p class="p1">./Traub_Figures/TraubFigure3</p> <p class="p2"><br></p> <p class="p1">and run the corresponding Matlab script:</p> <p class="p2"><br></p> <p class="p1">Graph_fig3Traub.m</p> <p class="p2"><br></p> <p class="p1">Comparison with the original paper figures are in the Traub_Figures>CompareOriginalFigs subdirectory</p> <p class="p2"><br></p> <p class="p2"><br></p> <p class="p2"><br></p> </body> </html>
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CA3 hippocampal pyramidal neuron with voltage-clamp intrinsic conductance data (Traub et al 1991)