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CN Octopus Cell: Ih current (Bal, Oertel 2000)
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NEURON mod files for the Ih current from the paper: R. Bal and D. Oertel Hyperpolarization-activated, mixed-cation current (Ih) in octopus cells of the mammalian Cochlear Nucleus, J. Neurophysiol. 84, 806-817 (2000) The current has been modeled as two independent HH-like gates with the same activation curve but different time constants (fast and slow). The two gates are added to give the current as : i_hcno = gbar_hcno*(v-eh)*(h1*frac+h2*(1-frac)) Running the kinetics.hoc simulation file will show the activation steady-state, the time constants, a simple simulation using a somatic current injection of -1.3nA, and a family of curves generated modeling the same protocol used in the experiments for Fig.6A of the paper. For Fig.6A the peak conductance has been adjusted to give approximately the same currents shown in the paper. The time constants reported in the paper are shown as markers of different colors. Time constants in the range not covered by the paper are an arbitrary extension. By changing the frac and color parameters one can model the relative percentage of fast and slow gates. Under unix systems: to compile the mod files use the command nrnivmodl and run the simulation hoc file with the command nrngui kinetics.hoc Under Windows using NEURON 5.1: to compile the mod files use the "mknrndll" command. A double click on the simulation file kinetics.hoc will open the simulation window. Questions on how to use this model should be directed to michele.migliore@pa.ibf.cnr.it
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CN Octopus Cell: Ih current (Bal, Oertel 2000)
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