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Add carbamazepine PK data for treatment phase
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AndreDlm authored Feb 2, 2024
1 parent 330b1a5 commit 3d3a720
Showing 1 changed file with 69 additions and 53 deletions.
122 changes: 69 additions & 53 deletions Cimetidine-Carbamazepine-DDI.json
Original file line number Diff line number Diff line change
Expand Up @@ -2296,6 +2296,9 @@
{
"Name": "Dalton1985a_TreatmentPhase",
"Model": "4Comp",
"ObservedData": [
"Dalton 1985a - Treatment with cimetidine - Carbamazepine - PO - 600 mg - Plasma - agg. (n=8)"
],
"Solver": {},
"OutputSchema": [
{
Expand Down Expand Up @@ -2785,6 +2788,13 @@
"Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)",
"Organism|PeripheralVenousBlood|Cimetidine|Plasma (Peripheral Venous Blood)"
],
"OutputMappings": [
{
"Scaling": "Log",
"Path": "Dalton1985a_TreatmentPhase|Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)",
"ObservedData": "Dalton 1985a - Treatment with cimetidine - Carbamazepine - PO - 600 mg - Plasma - agg. (n=8)"
}
],
"Individual": "Dalton1985a",
"Compounds": [
{
Expand Down Expand Up @@ -2926,6 +2936,17 @@
"Color": "#FF0000",
"LegendIndex": 2
}
},
{
"Name": "Dalton 1985a - Treatment with cimetidine - Carbamazepine - PO - 600 mg - Plasma - agg. (n=8)-Carbamazepine-Peripheral Venous Blood-Plasma-Individual",
"X": "Dalton 1985a - Treatment with cimetidine - Carbamazepine - PO - 600 mg - Plasma - agg. (n=8)|Time",
"Y": "Dalton 1985a - Treatment with cimetidine - Carbamazepine - PO - 600 mg - Plasma - agg. (n=8)|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|Individual",
"CurveOptions": {
"Color": "#0000FF",
"LegendIndex": 3,
"LineStyle": "None",
"Symbol": "Circle"
}
}
],
"Name": "Dalton1985_control_600mg_sd_tabIR",
Expand Down Expand Up @@ -3137,7 +3158,7 @@
}
},
{
"Name": "Dalton 1985a - Placebo (without cimetidine) - Carbamazepine-10-11-epoxide - PO - 600 mg - Plasma - agg. (n=8)",
"Name": "Dalton 1985a - Treatment with cimetidine - Carbamazepine - PO - 600 mg - Plasma - agg. (n=8)",
"ExtendedProperties": [
{
"Name": "DB Version",
Expand All @@ -3146,7 +3167,7 @@
},
{
"Name": "ID",
"Value": 899.0,
"Value": 900.0,
"Type": "Double"
},
{
Expand All @@ -3166,7 +3187,7 @@
},
{
"Name": "Grouping",
"Value": "Placebo (without cimetidine)",
"Value": "Treatment with cimetidine",
"Type": "String"
},
{
Expand All @@ -3181,7 +3202,7 @@
},
{
"Name": "Molecule",
"Value": "Carbamazepine-10-11-epoxide",
"Value": "Carbamazepine",
"Type": "String"
},
{
Expand Down Expand Up @@ -3211,7 +3232,7 @@
},
{
"Name": "Times of Administration [h]",
"Value": 0.0,
"Value": 47.0,
"Type": "Double"
},
{
Expand All @@ -3234,32 +3255,34 @@
{
"Name": "Avg",
"QuantityInfo": {
"Path": "Dalton 1985a - Placebo (without cimetidine) - Carbamazepine-10-11-epoxide - PO - 600 mg - Plasma - agg. (n=8)|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine-10-11-epoxide|Individual"
"Path": "Dalton 1985a - Treatment with cimetidine - Carbamazepine - PO - 600 mg - Plasma - agg. (n=8)|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|Individual"
},
"DataInfo": {
"Origin": "Observation",
"AuxiliaryType": "Undefined",
"MolWeight": 252.27
"MolWeight": 236.269
},
"Values": [
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"Dimension": "Concentration (mass)",
"Unit": "mg/l"
Expand All @@ -3268,45 +3291,38 @@
"BaseGrid": {
"Name": "Time",
"QuantityInfo": {
"Path": "Dalton 1985a - Placebo (without cimetidine) - Carbamazepine-10-11-epoxide - PO - 600 mg - Plasma - agg. (n=8)|Time",
"Path": "Dalton 1985a - Treatment with cimetidine - Carbamazepine - PO - 600 mg - Plasma - agg. (n=8)|Time",
"Type": "Time"
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"AuxiliaryType": "Undefined"
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],
"Dimension": "Time",
"Unit": "h"
}
}
],
"ObservedDataClassifications": [
{
"Name": "Dalton 1985a",
"Classifiables": [
"Dalton 1985a - Placebo (without cimetidine) - Carbamazepine - PO - 600 mg - Plasma - agg. (n=8)",
"Dalton 1985a - Placebo (without cimetidine) - Carbamazepine-10-11-epoxide - PO - 600 mg - Plasma - agg. (n=8)"
]
}
]
}

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