Update README.md

README.md

@@ -1,12 +1,12 @@
-## Digoxin-Model
+# Digoxin-Model
 Whole-body PBPK model of digoxin as P-gp DDI victim drug 
 
 
 <p align="center">
   <img src="DDI-Modeling-Network.png">
 </p>
 
-### Repository files
+## Repository files
 Within this repository, we distribute a whole-body PBPK model of digoxin, that has been carefully developed using a large number of clinical studies and evaluated within our DDI modeling network. 
 
 The PK-Sim project file contains simulations of all published clinical studies employed during model establishment, including the respective observed data digitized from literature reports. For further details, quantitative model evaluation, sensitivity analysis and extensive documentation please refer to [[1](#reference)].
@@ -20,5 +20,5 @@ We encourage contribution to the Open Systems Pharmacology community. Before get
 ## License
 The model code is distributed under the [GPLv2 License](https://github.com/Open-Systems-Pharmacology/Suite/blob/develop/LICENSE).
 
-### Reference
+## Reference
 [1] [Hanke N, Frechen S, Moj D, Britz H, Eissing T, Wendl T, Lehr T. PBPK models for CYP3A4 and P-gp DDI prediction: a modeling network of rifampicin, itraconazole, clarithromycin, midazolam, alfentanil and digoxin. CPT: Pharmacometrics & Systems Pharmacology (2018), https://doi.org/10.1002/psp4.12343.](https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1002/psp4.12343)