Exemplary Protein PBPK Models
The file "protein_model_expamples.pksim5" contains two exemplary simulations using the protein model. They describe the PK of the antibody CDA1 (reported in C. P. Taylor et al. (2008), Vaccine, 26(27-28), 3404-3409) and a domain antibody (reported in A. Sepp et al. (2015), J Pharmacokinet Pharmacodyn, 42(2), 97-109).
The simulations are also described in C. Niederalt et al. (2018), J Pharmacokinet Pharmacodyn 45 (2), 235–257.
The physiology is based on the PBPK model implemented in PK-Sim version 7.1.0. The PK-Sim project files were created in version 7.2.1.
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The model code is distributed under the GPLv2 License.