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Exemplary-Protein-Models

Exemplary Protein PBPK Models

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The file "protein_model_expamples.pksim5" contains two exemplary simulations using the protein model. They describe the PK of the antibody CDA1 (reported in C. P. Taylor et al. (2008), Vaccine, 26(27-28), 3404-3409) and a domain antibody (reported in A. Sepp et al. (2015), J Pharmacokinet Pharmacodyn, 42(2), 97-109).

The simulations are also described in C. Niederalt et al.  (2018), J Pharmacokinet Pharmacodyn 45 (2), 235–257.

Version information

The physiology is based on the PBPK model implemented in PK-Sim version 7.1.0. The PK-Sim project files were created in version 7.2.1.

Code of conduct

Everyone interacting in the Open Systems Pharmacology community (codebases, issue trackers, chat rooms, mailing lists etc...) is expected to follow the Open Systems Pharmacology code of conduct.

Contribution

We encourage contribution to the Open Systems Pharmacology community. Before getting started please read the contribution guidelines. If you are contributing code, please be familiar with the coding standard.

License

The model code is distributed under the GPLv2 License.