This release contains the qualification plan (qualification_plan.json) including references to respective model snapshots and static content (e.g. text blocks, *.md files) to produce a qualification report evaluating the ability to perform simulations with the intended purpose to predict cytochrome P450 3A4 (CYP3A4)-mediated drug-drug interactions (DDI) of the PBPK platform PK-Sim (as part of the open systems pharmacology (OSP) suite).
The latest release of the qualification report can be found here.
Major updates
- Carbamazepine added to the CYP3A4 DDI network: The interactions between carbamazepine as perpetrator and the victim drugs alprazolam, efavirenz, and midazolam are included as well as the interactions between carbamazepine as victim drug and cimetidine, efavirenz, and erythromycin as perpetrators.
Minor updates
- minor editorial updates and bug fixes: #31
- updated with cimetidine release version v1.2
Full Changelog: v1.4...v1.5