Theophylline-Model

Whole-body PBPK model of theophylline as CYP1A2 DDI victim drug

Repository files

Within this repository, we distribute a whole-body PBPK model of theophylline, that has been carefully developed using a large number of clinical studies and evaluated within our DDI modeling network.

The PK-Sim project file contains simulations of all published clinical studies employed during model establishment, including the respective observed data digitized from literature reports. For further details, quantitative model evaluation, sensitivity analysis and extensive documentation please refer to [1].

Code of conduct

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Contribution

We encourage contribution to the Open Systems Pharmacology community. Before getting started please read the contribution guidelines. If you are contributing code, please be familiar with the coding standard.

License

The model code is distributed under the GPLv2 License.

Reference

[1] Britz H, Hanke N, Volz AK, Spigset O, Schwab M, Eissing T, Wendl T, Frechen S, Lehr T. PBPK models for CYP1A2 DDI prediction: a modelling network of fluvoxamine, theophylline, caffeine, rifampicin and midazolam. CPT Pharmacometrics Syst Pharmacol 2019, https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1002/psp4.12397.