Whole-body PBPK model of valproic acid including non-linear binding with albumin in adults, children and children with hypoalbuminemia.
The model has then been evaluated simulating a large number of clinical studies and comparing with respective observed data, obtained from published clinical pharmacokinetic studies.
This model has been published1.
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The model code is distributed under the GPLv2 License.
[1] Karatza, E., Sinha, J., Maglalang, P. D., Edginton, A., & Gonzalez, D. (2024). Physiologically-Based Pharmacokinetic Modeling of Total and Unbound Valproic Acid to Evaluate Dosing in Children With and Without Hypoalbuminemia. Clinical pharmacokinetics, 63(10), 1435–1448. https://doi.org/10.1007/s40262-024-01418-8