GitHub - OpenNeuroDatasets/ds005529: OpenNeuro dataset - DP-pCASL data (CBF, ATT, BBB kw) from 186 cognitively normal participants (8-92 years).

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OpenNeuro dataset - DP-pCASL data (CBF, ATT, BBB kw) from 186 cognitively normal participants (8-92 years).

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This data set contains CBF, ATT and blood-brain barrier (BBB) kw (water exchange rate) acquired using DP-pCASL technique from 186 cognitively normal participant with age 8-92 years. 

For details about the age-related patterns of perfusion and BBB function changes in healthy populations, please refer to our eLife paper: 

Shao et al.,  Age-Related Decline in Blood-Brain Barrier Function is More Pronounced in Males than Females in Parietal and Temporal Regions eLife 13:RP96155

For details about DP-pCASL technique, please refer to: 

Shao X, et al., Mapping water exchange across the blood-brain barrier using 3D diffusion-prepared arterial spin labeled perfusion MRI. Magn Reson Med. 2019 May;81(5):3065-3079. doi: 10.1002/mrm.27632.

Shao X, et al., Quantification of blood-brain barrier water exchange and permeability with multidelay diffusion-weighted pseudo-continuous arterial spin labeling. Magn Reson Med. 2023 May;89(5):1990-2004. doi: 10.1002/mrm.29581.

For questions, please contact Dr. Xingfeng Shao (xshao@ini.usc.edu) and Dr. Danny JJ Wang (jj.wang@loni.usc.edu).

Thanks for your interest!

09/25/2024