This is the readme for the author's model which replicates Figure 3 and Supplementary Figure 9 in the paper: Gidon A, Zolnik TA, Fidzinski P, Bolduan F, Papoutsi A, Poirazi P, Holtkamp M, Vida I, Larkum ME (2020) Dendritic action potentials and computation in human layer 2/3 cortical neurons Science 367:83-87, http://dx.doi.org/10.1126/science.aax6239
The author's models associated with Supplementary Figure 12 is available here: http://modeldb.yale.edu/260178 or under FigS12codes/ subdirectory of this repo.
Model usage: This code was written in and requires NEURON (tested in version 7.4, 7.7) which is freely available from http://www.neuron.yale.edu
This model was run under the unix/linux and windows 10 operating system.
Proceed as follows:
- Download and expand this archive and compile the mod files located in the "_mod" folder with
nrnivmodl(nrnivmodl _modornrnivmodl ../_modif running in the Fig3andS9 subfolder).
x84/64/special mosinit.hoc
or for windows double click mosinit.hoc
If you need more help running NEURON on your platform please consult: https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide
Once the code is running you can select a simulation from a menu of buttons to click:
After each simulation is run you will need to restart to generate another simulation. As examples clicking the first, second, and fith buttons quickly generates these figures:
