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RichardDShipman/README.md

Hi there 👋

I am a bioinformatician with a background in applied science, with a concentration in biochemistry and molecular biology. Throughout my life, I’ve been tinkering with computers, which naturally led me to support the projects I pursue. Past experiences involved developing computational proteomics tools that enable the discovery and application of novel phosphopeptides and glycopeptides with desired properties. I am currently enrolled as a Master student in Omics Data Analysis at the University of Vic - Central University of Catalonia (UVic-UCC). I enjoy exploring the intersection of different omics fields with the aid of computational tools. The projects listed below highlight some of those adventures.

Recent Projects

Here is a list of recent projects I have been toying with on my free time.

  1. Glycopeptide Proteoform Generator (https://github.com/RichardDShipman/glycopeptide_proteoform_generator)
  • A script to generate proteoforms by reading glycopeptide data from a CSV file, with limits on the number of proteoforms, saving results in both CSV and text file formats for each protein.
  1. Glycoproteomics Graph Tool (https://github.com/RichardDShipman/GlycoproteomicsGraphTool_release)
  • Neo4j based graph knowledge base for storing glycoproteomics records in context to the central dogma of molecular biology.

Past Projects

Here is a list of past projects I have worked on, with links to related GitHub repositories if they are available.

  1. Glycoproteomics Knowledge Database Development
  • Developed a Neo4j graph database for glycomics, integrating public and proprietary multi-omics data to enhance biomarker discovery for various disease indications.
  1. Glycoproteomics Mass Spectrometry Deep Learning Pipeline (https://github.com/Vennbiosciences/D-Va-GlycoML)
  • Optimized a Python-based machine learning pipeline for glycoproteomics mass spectrometry, improving the accuracy of N-glycopeptide identification using deep learning models to analyze fragmentation patterns.
  1. N-Linked Glycoform Categorization (10.1016/j.mcpro.2021.100081)
  • Developed R scripts for categorizing glycoforms based on mass spectrometry data, contributing to the analysis of glycosylation patterns in diseases.

Technical Skills

  • Languages: Python, R, Bash
  • Data Management: SQL, Neo4j - Cypher
  • Data Visualization: R Shiny, Neodash, ggplot2
  • Bioinformatics: Omics Data Analysis, Mass Spectrometry, Proteomics, Glycomics, Glycoproteomics

Pinned Loading

  1. GlycoproteomicsGraphTool_release GlycoproteomicsGraphTool_release Public

    Neo4j graph knowledgebase Glycoproteomics Graph Tool for storing glycopeptide records.

    Cypher

  2. glycopeptide_proteoform_generator glycopeptide_proteoform_generator Public

    Generate proteoforms from a list of glycopeptides.

    Python